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Influence of salt loading on the cardiac and renal preproendothelin-1 mRNA expression in stroke-prone spontaneously hypertensive rats.

Abstract：

:Endothelin-1 is a potent vasoactive peptide which may play a role in the regulation of vascular resistance through its autocrine/paracrine effects. We have investigated the influence of salt loading on the renal and cardiac production of endothelin-1 in stroke prone spontaneously hypertensive rats, a classical model of hypertension. The results show that the dietary salt intake did not change systolic blood pressure nor the renal expression of the preproendothelin-1 mRNA but increased cardiac expression of the endothelin-1 gene transcript and a concomitant ventricular hypertrophy.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Feron O,Salomone S,Godfraind T

doi

10.1006/bbrc.1995.1484

subject

Has Abstract

pub_date

1995-04-06 00:00:00

pages

161-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71484-2

journal_volume

209

pub_type

杂志文章

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