Isolation and characterization of four basic proteins from horse eosinophilic granules.

abstract：:We demonstrate for the first time that major structural changes are imposed on various phospholipid bilayers by diacylglycerol, a product of phosphatidylinositol metabolism. By 5 mole percent in phosphatidylethanolamine a lamellar to hexagonal transition starts that is complete at 10 mole percent. At 30 mole percent i...

journal_title：Biochemical and biophysical research communications

authors： Das S,Rand RP

更新日期：1984-10-30 00:00:00

abstract：:Pulmonary fibrosis is a progressive disorder whose molecular pathology is poorly understood. Here we developed an in-house cDNA microarray ("lung chip") originating from a lung-normalized cDNA library. By using this lung chip, we analyzed global gene expression in a murine model of bleomycin-induced fibrosis and selec...

journal_title：Biochemical and biophysical research communications

authors： Katsuma S,Nishi K,Tanigawara K,Ikawa H,Shiojima S,Takagaki K,Kaminishi Y,Suzuki Y,Hirasawa A,Ohgi T,Yano J,Murakami Y,Tsujimoto G

更新日期：2001-11-09 00:00:00

abstract：:Although "secretory" type II 14-kDa phospholipase A2 (sPLA2) activity has been described in neutrophils, direct evidence of enzyme secretion has been elusive. We have used immunogold electron microscopy with polyclonal and monoclonal antibodies to sPLA2 to demonstrate localization of the enzyme to granules of resting ...

journal_title：Biochemical and biophysical research communications

authors： Rosenthal MD,Gordon MN,Buescher ES,Slusser JH,Harris LK,Franson RC

更新日期：1995-03-17 00:00:00

abstract：:This article has been withdrawn at the request of the author. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Seong ES,Cho HS,Choi D,Joung YH,Lim CK,Hur JH,Wang MH

更新日期：2007-11-21 00:00:00

abstract：:8-iso-PGE2, an E2-isoprostane, decreased GFR and RPF dose-dependently in rats, but with lesser potency than 8-epi-PGF2 alpha, an F2-isoprostane. This effect was abolished by SQ29,548. 8-iso-PGE2 displaced [3H]SQ29,548 or [125I]BOP binding in aortic smooth muscle cells with the affinity rank order of SQ29,548 > = I-BOP...

journal_title：Biochemical and biophysical research communications

authors： Fukunaga M,Takahashi K,Badr KF

更新日期：1993-09-15 00:00:00

abstract：:We have identified and characterized the novel human transmembrane protein 9 (TMEM9). TMEM9 encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites, and three conserved cys-rich domains in the N-terminus, but no hitherto known fu...

journal_title：Biochemical and biophysical research communications

authors： Kveine M,Tenstad E,Døsen G,Funderud S,Rian E

更新日期：2002-10-04 00:00:00

abstract：:Diacylglycerol kinase (DGK) plays an important role in phosphoinositide signaling cascade by regulating the intracellular level of diacylglycerol and phosphatidic acid. The DGK family is involved in various pathophysiological responses that are mediated through unique binding partners in different tissues and cells. I...

journal_title：Biochemical and biophysical research communications

authors： Okada M,Hozumi Y,Iwazaki K,Misaki K,Yanagida M,Araki Y,Watanabe T,Yagisawa H,Topham MK,Kaibuchi K,Goto K

更新日期：2012-04-06 00:00:00

abstract：:Tyrosinase catalyzes in mammals the first and rate-limiting step in the biosynthesis of the melanin, the main pigment of the skin. Pterins, heterocyclic compounds able to photoinduce oxidation of DNA and its components, accumulate in the skin of patients suffering from vitiligo, a chronic depigmentation disorder in wh...

journal_title：Biochemical and biophysical research communications

authors： Laura Dántola M,Gojanovich AD,Thomas AH

更新日期：2012-08-03 00:00:00

abstract：:Current studies were undertaken to determine the presence of a specific antigenic protein on the outer membrane of Salmonella typhi. Immunoblot analysis using sera from patients with fevers revealed that the 50 kD band was specifically recognized only by typhoid sera. The 50 kD band located on the outer membrane is pr...

journal_title：Biochemical and biophysical research communications

authors： Ismail A,Hai OK,Kader ZA

更新日期：1991-11-27 00:00:00

abstract：:RNF8 is a nuclear protein having an N-terminal forkhead-associated (FHA) domain and a C-terminal RING-finger (RF) domain. Depletion of RNF8 caused cell growth inhibition and cell cycle arrest at not only S but also G2/M phases. In addition, cell death was frequently observed in RNF8-depleted cells. Analyses of time-la...

journal_title：Biochemical and biophysical research communications

authors： Yoshioka T,Kimura M,Saio M,Era S,Okano Y

更新日期：2011-06-24 00:00:00

abstract：:Vasodilator-stimulated phosphoprotein (VASP) is an actin regulatory protein that functions in adhesion and migration. In epithelial cells, VASP participates in cell-cell adhesion. At the molecular level, VASP drives actin bundling and polymerization. VASP activity is primarily regulated by phosphorylation. Three physi...

journal_title：Biochemical and biophysical research communications

authors： Thomson DM,Ascione MP,Grange J,Nelson C,Hansen MD

更新日期：2011-10-14 00:00:00

abstract：:Polyclonal, anti-idiotypic, rabbit antibodies have been raised against four murine monoclonal anti-morphine Fab fragments. The antibody preparations, after affinity purification, have been shown to contain an anti-paratypic fraction which reversibly inhibits morphine binding to the anti-morphine antibodies and to cell...

journal_title：Biochemical and biophysical research communications

authors： Glasel JA,Pelosi LA

更新日期：1986-05-14 00:00:00

abstract：:Cloned murine mammary tumor virus (MuMTV) sequences allowed us to search for murine mammary tumor virus related sequences in the DNA of surgically removed human breast tumors. Out of 28 tumors so far examined two were found to contain an Eco RI DNA fragment homologous to the long terminal repeat-group antigen (LTR-Gag...

journal_title：Biochemical and biophysical research communications

authors： Crépin M,Lidereau R,Chermann JC,Pouillart P,Magdamenat H,Montagnier L

更新日期：1984-01-13 00:00:00

abstract：:Osteoblasts regulate bone formation and remodeling, and are main target cells of oxidative stress in the progression of osteonecrosis. The stem cell factor (SCF)-c-Kit pathway plays important roles in the proliferation, differentiation and survival in a range of cell types, but little is known about its functions in o...

journal_title：Biochemical and biophysical research communications

authors： Yang L,Wu Z,Yin G,Liu H,Guan X,Zhao X,Wang J,Zhu J

更新日期：2014-12-12 00:00:00

abstract：:Phosphofructokinase (PFK) from human polymorphonuclear leukocytes (PMN) was characterized by immunological titration with subunit specific antibodies and column chromatography on QAE-Sephadex in three different groups: control, type II diabetic, and obese individuals. It was found that PMN phosphofructokinase in the t...

journal_title：Biochemical and biophysical research communications

authors： Durante P,Raleigh X,Gómez ME,Campos G,Ryder E

更新日期：1996-08-23 00:00:00

abstract：:Keratins are a family of structurally related proteins that form the intermediate filament cytoskeleton in epithelial cells. Mutations in K1 and K5 result in the autosomal dominant disorders epidermolytic hyperkeratosis/bullous congenital ichthyosiform erythroderma and epidermolysis bullosa simplex, respectively. Most...

journal_title：Biochemical and biophysical research communications

authors： Whittock NV,Eady RA,McGrath JA

更新日期：2000-07-21 00:00:00

abstract：:Lipid accumulation in pancreatic beta-cells during high-fat (HF) feeding may be involved in inducing a defective insulin secretion due to lipotoxicity. Hormone-sensitive lipase (HSL) is expressed and active in beta-cells, but its importance for islet dysfunction during the development of type 2 diabetes is not known. ...

journal_title：Biochemical and biophysical research communications

authors： Winzell MS,Holm C,Ahrén B

更新日期：2003-05-02 00:00:00

abstract：:Thrombin receptor-derived peptide SFLLRNP (one-letter amino acid code) which corresponds to the N-terminal heptapeptide of tethered ligand is able to activate thrombin receptor and to stimulate the phosphoinositide (PI) turnover. The replacement of Phe-2 by Ala eliminated this activity completely, showing the crucial ...

journal_title：Biochemical and biophysical research communications

authors： Nose T,Shimohigashi Y,Ohno M,Costa T,Shimizu N,Ogino Y

更新日期：1993-06-15 00:00:00

abstract：:Erythroid band 4.1 enhances the binding of erythroid spectrin to phosphatidylserine vesicles under conditions of ionic strength and at protein concentrations similar to those in the red cell. The extent of enhancement depends on the concentration of band 4.1; at 2 microM 4.1, spectrin binding increases approximately 1...

journal_title：Biochemical and biophysical research communications

authors： Takeshita K,MacDonald RI,MacDonald RC

更新日期：1993-02-26 00:00:00

abstract：:Using atomic force microscopy (AFM), we find that RecA-single-stranded DNA (RecA-ssDNA) filaments, in the presence of single-stranded DNA-binding (SSB) protein, organize into left-handed bundles, which differ from the previously reported disordered aggregates formed when SSB is excluded from the reaction. In addition,...

journal_title：Biochemical and biophysical research communications

authors： Shi WX,Larson RG

更新日期：2007-06-08 00:00:00

abstract：:The expression and secretion of Transforming Growth Factor beta1 (TGFbeta1) by cultured testes of day 20.5 rat fetuses were investigated. The testes were found to express two TGFbeta1 mRNA transcripts of 2.5 and 1.8 kb. By using mink lung epithelial cell bioassay based on the measurement of the inhibition of tritiated...

journal_title：Biochemical and biophysical research communications

authors： Gautier C,Levacher C,Saez JM,Habert R

更新日期：1997-07-09 00:00:00

abstract：:Aggregation of amyloid beta-peptide (Abeta), a key pathological event in Alzheimer's disease, has been shown in vitro to be profoundly promoted by Zn(II). This fact suggests that some factors in the normal brain protect Abeta from the Zn(II)-induced aggregation. We demonstrate for the first time that Cu(II) effectivel...

journal_title：Biochemical and biophysical research communications

authors： Suzuki K,Miura T,Takeuchi H

更新日期：2001-07-27 00:00:00

abstract：:We studied the transcriptional regulation of human GM3 synthase (hST3Gal V) during megakaryocytic differentiation of K562 cells induced by PMA. Northern blot and reverse transcription polymerase chain reaction (RT-PCR) indicated that the induction of hST3Gal V by phorbol 12-myristate 13-acetate (PMA) is regulated at t...

journal_title：Biochemical and biophysical research communications

authors： Choi HJ,Chung TW,Kang NY,Kim KS,Lee YC,Kim CH

更新日期：2004-01-02 00:00:00

abstract：:Long-term glucocorticoid (GC) usage may cause non-traumatic femoral head osteonecrosis. Dexamethasone (Dex) is shown to exert potent cytotoxic effect to osteoblasts. Here, we investigated the potential activity of α-melanocyte stimulating hormone (α-MSH) against the process. Our data revealed that pretreatment of α-MS...

journal_title：Biochemical and biophysical research communications

authors： Guo S,Xie Y,Fan JB,Ji F,Wang S,Fei H

更新日期：2016-01-08 00:00:00

abstract：:We have isolated a rabbit metallothionein-I gene from a lambda gt10 library. The coding sequence of this gene is interrupted by two introns occurring at amino acid positions 9 1/3 and 30 1/3. Comparison of the promoter sequence of this gene with the promoters of other metallothionein genes identified a number of oligo...

journal_title：Biochemical and biophysical research communications

authors： Tam YC,Chopra A,Hassan M,Thirion JP

更新日期：1988-05-31 00:00:00

abstract：:Previously, the comparison of human MNB/DYRK cDNA sequences with publicly available genomic DNA sequence made a conclusion that MNB/DYRK gene consists of 11 exons spanning 100 kb. Here we found a novel human MNB/DYRK cDNA clone that has the 5' end different from any of those reported MNB/DYRK cDNAs. The 5' end of this...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Kudoh J,Shintani A,Minoshima S,Shimizu N

更新日期：1998-09-29 00:00:00

abstract：:Previous studies in our laboratory have shown that specific glycan structures are required for the normal secretion of some glycoproteins. Bromoconduritol is known to inhibit the removal of the innermost glucose moiety from the Glc3Man9(GlcNAc)2 precursor of N-linked glycoproteins. We have used this inhibitor to inves...

journal_title：Biochemical and biophysical research communications

authors： Yeo KT,Yeo TK,Olden K

更新日期：1989-06-30 00:00:00

abstract：:Heat shock proteins are detectable in human atherosclerotic plaques, especially in endothelial cells. In this report we show by immunofluorescence that incubation "in vitro" with OxLDL is a stress capable of inducing the expression of heat shock protein 70 in both the EAhy-926 cell line and human umbilical vein endoth...

journal_title：Biochemical and biophysical research communications

authors： Zhu W,Roma P,Pellegatta F,Catapano AL

更新日期：1994-04-15 00:00:00

abstract：:Plasminogen activation by tissue-plasminogen activator (t-PA) is accelerated by the presence of a macromolecular surface, which acts as a template that brings enzyme and substrate in close proximity. Modification of lysine residues, which are important for this template function, occurs in diabetic patients as a conse...

journal_title：Biochemical and biophysical research communications

authors： Bobbink IW,Tekelenburg WL,Sixma JJ,de Boer HC,Banga JD,de Groot PG

更新日期：1997-11-26 00:00:00

abstract：:The fragile X mental retardation 1 (FMR1) protein binds mRNA and acts as a negative regulator of translation. Lack of FMR1 causes the most common neurological disorder, fragile X syndrome, while its overexpression is associated with metastasis of breast cancer. Its activity has been well-studied in nervous tissue, but...

journal_title：Biochemical and biophysical research communications

authors： Choi YN,Jeong DH,Lee JS,Yoo SJ

更新日期：2014-10-10 00:00:00