Regulatory role of GM3 ganglioside in integrin function, as evidenced by its effect on function of alpha 5 beta 1-liposomes: a preliminary note.

Abstract:

:Mouse mammary carcinoma mutant cell line FUA169, characterized by high GM3 ganglioside content, was established from parent cell line FM3A/F28-7, which has high LacCer content but no GM3. Although both cell lines showed the same quantity and quality of integrin receptors, FUA169 showed much stronger adhesion to fibronectin (FN)-coated plates than did F28-7. Liposomes containing phosphatidylcholine, cholesterol, alpha 5 beta 1, and a moderate amount of GM3 showed greatly enhanced adhesion to FN-coated plates, but adhesion of similar liposomes containing a large amount of GM3, or no GM3, was much lower. Our results suggest that GM3 regulates integrin receptor function essential for cell adhesion to FN.

authors

Zheng M,Tsuruoka T,Tsuji T,Hakomori S

doi

10.1016/s0006-291x(05)81561-x

subject

Has Abstract

pub_date

1992-08-14 00:00:00

pages

1397-402

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)81561-X

journal_volume

186

pub_type

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