当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Endothelin-1 peptides and IL-5 synergistically increase the expression of IL-13 in eosinophils.

Endothelin-1 peptides and IL-5 synergistically increase the expression of IL-13 in eosinophils.

Abstract：

:The 21-amino acid-length endothelin-1 (ET-1)(1-21) and its novel derivative, 31 amino acid-length ET-1(1-31), have proinflammatory properties and induce significant eosinophil migration mediated by an increase in the local levels of eotaxin and IL-5. We have analyzed by reverse transcription polymerase chain reaction and enzyme immunoassay the effects of ETs on the expression of IL-13 mRNA and protein in eosinophils with or without cell priming with IL-5. The expression of the ETA receptor (ETAR) and its membrane localization were detected in the eosinophils, whereas the ETB receptor was undetectable. ET peptides synergistically increased the expression of IL-13 in eosinophils after priming with IL-5, and the increase was blocked by the ETAR antagonist BQ123, though these peptides did not directly influence the expression. These results may explain the presence of eosinophilia in the airways' epithelium of patients suffering from asthma, along with an increase in immunoreactive ETs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cui P,Sharmin S,Okumura Y,Yamada H,Yano M,Mizuno D,Kido H

doi

10.1016/j.bbrc.2004.01.168

subject

Has Abstract

pub_date

2004-03-19 00:00:00

pages

782-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006291X04002293

journal_volume

315

pub_type

杂志文章

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