Insulin-like growth factor I stimulates transcription of the c-jun proto-oncogene in Balb/C 3T3 cells.

abstract：:The tissue targeting and rate of clearance of cobra venom factor (CVF) from the circulation was studied in mice by intravenous or intraperitoneal injection of radioiodinated CVF. In both modes of administrations, CVF was targeted mainly to liver. CVF injected directly into the blood was cleared from the circulation wi...

journal_title：Biochemical and biophysical research communications

authors： Fu Q,Satyaswaroop PG,Gowda DC

更新日期：1997-02-13 00:00:00

abstract：:The hyperpolarization-activated cation current I(h) is an important regulator of neuronal excitability and may contribute to the properties of the dentate gyrus granule (DGG) cells, which constitute the input site of the canonical hippocampal circuit. Here, we investigated changes in I(h) in DGG cells in human tempora...

journal_title：Biochemical and biophysical research communications

authors： Surges R,Kukley M,Brewster A,Rüschenschmidt C,Schramm J,Baram TZ,Beck H,Dietrich D

更新日期：2012-03-30 00:00:00

abstract：:Human erythrocyte G6PD activity was measured in more than 500 subjects in Isfahan, Iran, and the percent of enzyme deficiency for males and females are reported. Some properties of the abnormal enzyme is compared with its normal counterpart. Apparent Km values of glucose 6-phosphate for the variant and normal enzymes ...

journal_title：Biochemical and biophysical research communications

authors： Haghighi B,Suzangar M,Yazdani A,Mehnat M

更新日期：1985-11-15 00:00:00

abstract：:The Mechanosensitive channel of Large conductance (MscL) allows bacteria to rapidly adapt to changing environmental conditions such as osmolarity. The MscL channel opens in response to increases in membrane tension, which allows for the efflux of cytoplasmic constituents. Here we describe the cloning and expression of...

journal_title：Biochemical and biophysical research communications

authors： Jones SE,Naik RR,Stone MO

更新日期：2000-12-09 00:00:00

abstract：:Cultured human endothelial cells produce increased levels of PA-I when stimulated with IL-1. The stimulatory effect was elicited by both alpha (pI 5) and beta (pI 7) IL-1 molecules. The effect was both dose and time-dependent, plateau reached after 8 h. The PA-I measured in cell extracts was SDS-resistant with an appa...

journal_title：Biochemical and biophysical research communications

authors： Grames M,Breviario F,Pintucci G,Millet I,Dejana E,van Damme J,Donati MB,Mussoni L

更新日期：1986-09-14 00:00:00

abstract：:Protein-binding DNA-regions inside and in the vicinity of the phenobarbital-inducible P450bm-3 gene from Bacillus megaterium were characterized by gel-retardation technique and foot-printing analysis. Regions with induction-dependent protein binding capacity were shown to be situated in -279bp/-215bp, -215bp/+83bp and...

journal_title：Biochemical and biophysical research communications

authors： Gaidamakova EK,Karginov VA,Kovalenko SP

更新日期：1994-02-15 00:00:00

abstract：:Recent data has suggested a role for nitric oxide (NO) both in the induction of immunity and as an effector of tissue injury in experimental models of inflammation. In this study, we have tested the efficacy of two inhibitors of NO synthase, NG-monomethyl-L-arginine (L-NMMA) and aminoguanidine (AG), to modify the auto...

journal_title：Biochemical and biophysical research communications

authors： Woolfson RG,Qasim FJ,Thiru S,Oliveira DB,Neild GH,Mathieson PW

更新日期：1995-12-14 00:00:00

abstract：:High serum selenium levels have been associated epidemiologically with increased incidence of type 2 diabetes. The major fraction of total selenium in serum is represented by liver-derived selenoprotein P (SeP). This study was undertaken to test for a hypothesized effect of hyperglycemia and the antihyperglycemic drug...

journal_title：Biochemical and biophysical research communications

authors： Speckmann B,Sies H,Steinbrenner H

更新日期：2009-09-11 00:00:00

abstract：:The active centre of NADPH-cytochrome P-450 reductase contains the lysine residue essential for catalytic activity. Chemical modification of epsilon-amino group of this lysine residue is the subject of the present study. To modify the epsilon-amino group, we have employed the periodate-oxidized NADP+ and NAD+ (o-NAD(P...

journal_title：Biochemical and biophysical research communications

authors： Slepneva IA,Weiner LM

更新日期：1988-09-15 00:00:00

abstract：:The bacterial toxin Shiga toxin (Stx) is transported retrogradely from early endosomes to the Golgi apparatus on its way to the endoplasmic reticulum (ER) and the cytosol. In this study we explored the functions of the two phosphoinositide binding proteins Sorting nexin 1 (SNX1) and Sorting nexin 2 (SNX2) in endosomal...

journal_title：Biochemical and biophysical research communications

authors： Utskarpen A,Slagsvold HH,Dyve AB,Skånland SS,Sandvig K

更新日期：2007-06-29 00:00:00

abstract：:Sequence was obtained from a cDNA clone, designated ERD1, isolated from a cDNA library of 1-hour-dehydrated plants of Arabidopsis thaliana L. The clone (3150 bp) contains an open reading frame of 946 amino acid residues with greater than 34% sequence identity to the regulatory subunit of the Clp ATP-dependent protease...

journal_title：Biochemical and biophysical research communications

authors： Kiyosue T,Yamaguchi-Shinozaki K,Shinozaki K

更新日期：1993-11-15 00:00:00

abstract：:Nanodisks (ND) are nanometer scale complexes of phospholipid and apolipoprotein that have been shown to function as drug delivery vehicles. ND harboring significant quantities of the antifungal agent, amphotericin B, or the bioactive isoprenoid, all trans retinoic acid, have been generated and characterized. As curren...

journal_title：Biochemical and biophysical research communications

authors： Iovannisci DM,Beckstead JA,Ryan RO

更新日期：2009-02-06 00:00:00

abstract：:In this study, we attempt to determine whether lycopene regulates inflammatory mediators in the ovalbumin (OVA)-induced murine asthma model. To address this, mice were sensitized and challenged with OVA, and then treated with lycopene before the last OVA challenge. Administration of lycopene significantly alleviated t...

journal_title：Biochemical and biophysical research communications

authors： Lee CM,Chang JH,Moon DO,Choi YH,Choi IW,Park YM,Kim GY

更新日期：2008-09-19 00:00:00

abstract：:Involucrin is an important marker of epithelial differentiation which expression is upregulated just after basal cells are pushed into the suprabasal layer in stratified epithelia. Several transcription factors and regulatory elements had been described as responsible for turning on the gene. However, it is evident th...

journal_title：Biochemical and biophysical research communications

authors： Azuara-Liceaga E,Sandoval M,Corona M,Gariglio P,López-Bayghen E

更新日期：2004-05-28 00:00:00

abstract：:Computer-based approaches identified PTE2 as a candidate human peroxisomal acyl-CoA thioesterase gene. The PTE2 gene product is highly similar to the rat cytosolic and mitochondrial thioesterases, CTE1 and MTE1, respectively, and terminates in a tripeptide sequence, serine-lysine-valine(COOH), that resembles the conse...

journal_title：Biochemical and biophysical research communications

authors： Jones JM,Gould SJ

更新日期：2000-08-18 00:00:00

abstract：:Abnormal lipid metabolism may contribute to the pathogenesis of non-alcoholic steatohepatitis (NASH). The ATP-binding cassette transporter A1 (ABCA1) protein mediates the transport of cholesterol and phospholipids from cells to apolipoprotein A-I (apoA-I) to generate nascent HDL particles. Previous studies revealed th...

journal_title：Biochemical and biophysical research communications

authors： Liang H,Wang Y

更新日期：2018-04-06 00:00:00

abstract：:Ovarian cancer (OC) is one of the most prevalent cancers with high fatality rate. In the present study, RT-PCR showed that the mRNA level of CDKN2B-AS1 was significantly upregulated while the miR-411-3p was downregulated in OC cell lines. In addition, the Sh-CDKN2B-AS1 resulted in the suppression of cell growth, invas...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Huang Y,Liu H,Su D,Luo F,Zhou F

更新日期：2019-06-18 00:00:00

abstract：:To explore the pathophysiologic roles of the obese (ob) gene product, leptin, in the development of obesity and hypertension, we examined ob gene expression and leptin secretion in obese spontaneously hypertensive rats (obese SHR or Koletsky rats) at the stage of established obesity and hypertension. Expression of the...

journal_title：Biochemical and biophysical research communications

authors： Hiraoka J,Hosoda K,Ogawa Y,Ikeda K,Nara Y,Masuzaki H,Takaya K,Nakagawa K,Mashimo T,Sawamura M,Koletsky RJ,Yamori Y,Nakao K

更新日期：1997-02-24 00:00:00

abstract：:Researchers frequently use 3T3-L1 adipocytes as a fat cell line, but the capacity of this line for insulin-mediated glucose transport is lower than that of primary isolated fat cells. In this study, we found that 5-azacytidine (5-aza-C), DNA methyltransferase 1 inhibitor, enhanced insulin-stimulated 2-deoxyglucose (2-...

journal_title：Biochemical and biophysical research communications

authors： Kuroda M,Onoyama R,Sasaki W,Sebe M,Kitamura T,Masumoto S,Tsutsumi R,Harada N,Sakaue H

更新日期：2020-02-16 00:00:00

abstract：:Incubation of purified protein kinase C with H2O2 results in the generation of a persistently activated form of the enzyme which is no longer dependent on Ca2+ or lipid cofactors. This oxidative activation of purified protein kinase C requires added Fe2+ in the incubation medium. Treatment of the soluble fraction of h...

journal_title：Biochemical and biophysical research communications

authors： Palumbo EJ,Sweatt JD,Chen SJ,Klann E

更新日期：1992-09-30 00:00:00

abstract：:The ubiquitin-proteasome pathway is an important regulatory system for the lifetime of inducible nitric-oxide synthase (iNOS), a high-output isoform compared to neuronal NOS (nNOS) and endothelial NOS (eNOS), to prevent overproduction of NO that could trigger detrimental effects such as cytotoxicity. Two E3 ubiquitin ...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto K,Nishiya T,Maekawa S,Horinouchi T,Ogasawara K,Uehara T,Miwa S

更新日期：2011-05-27 00:00:00

abstract：:Parenteral immunization of transgenic mouse models of Alzheimer disease (AD) with synthetic amyloid beta-peptide (Abeta) prevented or reduced Abeta deposits and attenuated their memory and learning deficits. A clinical trial of immunization with synthetic Abeta, however, was halted due to brain inflammation, presumabl...

journal_title：Biochemical and biophysical research communications

authors： Fukuchi K,Accavitti-Loper MA,Kim HD,Tahara K,Cao Y,Lewis TL,Caughey RC,Kim H,Lalonde R

更新日期：2006-05-26 00:00:00

abstract：:Multiple deletions of mtDNA have not only been implicated in aging, but also in a wide variety of pathological conditions. The enzyme system used in long-PCR makes it possible to synthesize the entire mitochondrial genome (16.5 kb), exposing the multiple deletions in mtDNAs implicated in and, at least partially, respo...

journal_title：Biochemical and biophysical research communications

authors： Reynier P,Malthiery Y

更新日期：1995-12-05 00:00:00

abstract：:The various manipulations involved in the isolation of membrane fragments from culture fluids of murine melanoma cells were examined to discern their effect on membrane fragment structure. Ultracentrifugation and gel chromatography were compared using the presence of marker enzymes and the sensitivity to a non-ionic d...

journal_title：Biochemical and biophysical research communications

authors： Taylor DD,Chou IN,Black PH

更新日期：1983-06-15 00:00:00

abstract：:The crude extracts from Sphingomonas paucimobilus containing 2-hydroxy fatty acid-rich sphingolipids were found to oxidize [1-14C]-myristate to 2-hydroxymyristate in the presence of NADH. The myristate-oxidation activity was partially purified about 290-fold from the cell-free extracts by ammonium sulfate fractionatio...

journal_title：Biochemical and biophysical research communications

authors： Matsunaga I,Kusunose E,Yano I,Ichihara K

更新日期：1994-06-30 00:00:00

abstract：:The vast majority of ovarian cancers originate in the ovarian surface epithelium. Unfortunately, there is a lack of appropriate animal models for ovarian cancer research. Spontaneously transformed mouse ovarian surface epithelial cells may provide a faithful animal model for human ovarian cancer. One such cell line (I...

journal_title：Biochemical and biophysical research communications

authors： Pengetnze Y,Steed M,Roby KF,Terranova PF,Taylor CC

更新日期：2003-09-19 00:00:00

abstract：:Histone deacetylase (HDAC) 10 is a member of class IIb HDACs, but its deacetylation targets and functions are poorly characterized. Recent investigation has proposed that HDAC10 deacetylates heat shock cognate protein 70 kDa (HSC70) after interaction. HSC70 plays an important role in chaperone-mediated autophagy (CMA)...

journal_title：Biochemical and biophysical research communications

authors： Obayashi H,Nagano Y,Takahashi T,Seki T,Tanaka S,Sakai N,Matsumoto M,Maruyama H

更新日期：2020-02-26 00:00:00

abstract：:During autophagy, the microtubule-associated protein light chain 3 (LC3), a specific autophagic marker in mammalian cells, is processed from the cytosolic form (LC3-I) to the membrane-bound form (LC3-II). In HEK293 cells stably expressing FLAG-tagged LC3, activation of protein kinase C inhibited the autophagic process...

journal_title：Biochemical and biophysical research communications

authors： Jiang H,Cheng D,Liu W,Peng J,Feng J

更新日期：2010-05-14 00:00:00

abstract：:Based on a previous finding that fusion of a somatic cell with an embryonic stem (ES) cell reprogrammed the somatic cell, genes for reprogramming transcription factors were selected and induced pluripotent stem (iPS) cell technology was developed. The cell fusion itself produced a tetraploid cell. To avoid nuclear fus...

journal_title：Biochemical and biophysical research communications

authors： Kim SM,Wada KI,Ueki M,Hosokawa K,Maeda M,Sakai Y,Ito Y

更新日期：2019-12-03 00:00:00

abstract：:Little is known about the gene structure and mRNA expression of cholecystokinin type-A(CCKA) receptor in animals or in human. By screening an EMBL phage library containing partially digested Long-Evans rat DNA, we isolated 7 genomic clones covering a continuous 27 kb region over which a rat CCKA receptor gene spanned....

journal_title：Biochemical and biophysical research communications

authors： Takata Y,Takiguchi S,Funakoshi A,Kono A

更新日期：1995-08-24 00:00:00