当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane.

Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane.

Abstract：

:The cellular molecular motor kinesin-1 mediates the microtubule-dependent transport of a range of cargo. We have previously identified an interaction between the cargo-binding domain of kinesin-1 heavy chain KIF5B and the membrane-associated SNARE proteins SNAP-25 and SNAP-23. In this study we further defined the minimal SNAP-25 binding domain in KIF5B to residues 874-894. Overexpression of a fragment of KIF5B (residues 594-910) resulted in significant colocalization with SNAP-25 with resulting blockage of the trafficking of SNAP-25 to the periphery of cells. This indicates that kinesin-1 facilitates the transport of SNAP-25 containing vesicles as a prerequisite to SNAP-25 driven membrane fusion events.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Morton AM,Cunningham AL,Diefenbach RJ

doi

10.1016/j.bbrc.2009.11.068

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

388-93

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)02243-8

journal_volume

391

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Novel regulation of protein kinase C-η.

    abstract：:Protein kinase C (PKC) is the receptor for tumor promoting phorbol esters, which are potent activators of conventional and novel PKCs, but persistent treatment with phorbol esters leads to downregulation of these PKCs. However, PKCη, a novel PKC isozyme, resists downregulation by tumor-promoting phorbol esters, but li...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.07.163

    authors： Pal D,Outram SP,Basu A

    更新日期：2012-09-07 00:00:00

  • ABCG2 membrane transporter in mature human erythrocytes is exclusively homodimer.

    abstract：:The human ABCG2 protein, a member of ABC transporter family, was shown to transport anti-cancer drugs and normal cell metabolites. Earlier studies have demonstrated the expression of ABCG2 in hematopoietic stem cells and erythroid cells; however little is known about the expression and activity of ABCG2 in mature eryt...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.219

    authors： Leimanis ML,Georges E

    更新日期：2007-03-09 00:00:00

  • Comparison of WNK4 and WNK1 kinase and inhibiting activities.

    abstract：:WNK kinases are novel serine/threonine protein kinases. Mutations in two members of the WNK family, WNK1 and WNK4, cause familial hyperkalemic hypertension. These kinases regulate ion transport across diverse epithelia; WNK4 reduces activity of the Na-Cl cotransporter activity and the potassium channel, ROMK, by reduc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.132

    authors： Wang Z,Yang CL,Ellison DH

    更新日期：2004-05-07 00:00:00

  • Echinophilic proteins stomatin, sorcin, and synexin locate outside gangliosideM1 (GM1) patches in the erythrocyte membrane.

    abstract：:The detergent (Triton X-100, 4°C)-resistant membrane (DRM)-associated membrane proteins stomatin, sorcin, and synexin (anexin VII) exposed on the cytoplasmic side of membrane were investigated for their lateral distribution in relation to induced ganglioside(M1) (GM1) raft patches in flat (discocytic) and curved (echi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.09.065

    authors： Mrówczyńska L,Salzer U,Perutková S,Iglič A,Hägerstrand H

    更新日期：2010-10-22 00:00:00

  • In vitro synthesis of a plant phospholipid transfer protein: a study by high performance liquid chromatography.

    abstract：:In order to study the biosynthesis of a plant phospholipid transfer protein (PLTP), poly (A)+RNAs have been prepared from maize seedlings and translated in vitro with a rabbit reticulocyte lysate. The newly synthesized proteins were then separated by fast protein liquid chromatography (FPLC) followed by SDS-PAGE or by...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91843-1

    authors： Tchang F,Laroche-Raynal M,Vergnolle C,Demandre C,Douady D,Grosbois M,Guerbette F,Delseny M,Kader JC

    更新日期：1985-11-27 00:00:00

  • Spermine and spermidine act as chemical chaperones and enhance chaperone-like and membranolytic activities of major bovine seminal plasma protein, PDC-109.

    abstract：:The major bovine seminal plasma protein, PDC-109, binds to choline phospholipids of the sperm plasma membrane and induces an efflux of cholesterol and choline phospholipids (cholesterol efflux), which is crucial for sperm capacitation. PDC-109 also exhibits chaperone-like activity and protects target proteins against ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.09.148

    authors： Singh BP,Saha I,Nandi I,Swamy MJ

    更新日期：2017-12-02 00:00:00

  • Procollagen type I C-proteinase enhancer is a naturally occurring connective tissue glycoprotein.

    abstract：:Using antibodies to the procollagen C-proteinase enhancer of mouse fibroblast culture medium, we have screened by immunoblotting extracts of several post natal mouse and rat tissues for the presence of the enhancer antigen. All rodent connective tissues were relatively rich in enhancer; lower amounts were found in ske...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81024-1

    authors： Kessler E,Mould AP,Hulmes DJ

    更新日期：1990-11-30 00:00:00

  • The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2.

    abstract：:The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (Mpro) and the RNA-dependent RNA poly...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.10.091

    authors： Jin Z,Wang H,Duan Y,Yang H

    更新日期：2020-11-21 00:00:00

  • Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1.

    abstract：:This paper reports the identification of a Rho family nucleotide exchange factor termed mNET1 as a candidate-interacting partner for the first PDZ domain of MAGI-1, a membrane-associated guanylate kinase with inverted arrangement of protein-protein interacting modules. mNET1 was identified in a yeast two-hybrid screen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4880

    authors： Dobrosotskaya IY

    更新日期：2001-05-18 00:00:00

  • The protein kinase C activator Bryostatin-1 induces the rapid release of TNF alpha from MONO-MAC-6 cells.

    abstract：:Bryostatin-1 is a natural activator of protein kinase C and currently examined in phase I trials as anticancer agent. We found that Bryostatin-1 induced tumor necrosis factor alpha (TNF alpha) expression in the human cell line MONO-MAC-6. Using Northern blot analysis and a bioassay for the detection of the cytokine we...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2413

    authors： Steube KG,Drexler HG

    更新日期：1995-09-25 00:00:00

  • Human cellular src gene product: identification of the myristoylated pp60c-src and blockage of its myristoyl acylation with N-fatty acyl compounds resulted in the suppression of colony formation.

    abstract：:A p60K protein in human colon adenocarcinoma tumor cell lines was identified as a myristoylated pp60c-src by fluorography and radioimmunoprecipitation analysis. Prevention of the myristoylation of pp60c-src was determined with N-fatty acyl glycinal compounds. Of the compounds tested, N-myristoyl glycinal diethylacetal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80870-8

    authors： Shoji S,Kurosawa T,Inoue H,Funakoshi T,Kubota Y

    更新日期：1990-12-31 00:00:00

  • Pramipexole pretreatment attenuates myocardial ischemia/reperfusion injury through upregulation of autophagy.

    abstract：:This article investigated the effects of pramipexole on myocardial ischemia reperfusion (I/R) injury and its underlying mechanisms. We utilized an in vivo mouse model of myocardial I/R injury and an in vitro H9c2 cell model of hypoxia/reoxygenation (H/R) injury. Pramipexole pretreatment in male C57BL/6 mice significan...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.04.026

    authors： Mo Y,Tang L,Ma Y,Wu S

    更新日期：2016-05-13 00:00:00

  • Solubilization of membrane-bound acid alpha-glucosidase by proteolysis.

    abstract：:The membrane-bound acid alpha-glucosidase was purified partially (400-fold) from human placenta by solubilization with trypsin, concanavalin A-Sepharose chromatography, Ultrogel AcA-34 gel filtration, and Sephadex G-100 affinity chromatography. Two molecular forms of the enzyme were found in the final preparation of t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80512-6

    authors： Tsuji A,Suzuki Y

    更新日期：1988-03-30 00:00:00

  • Diethanolamine inhibits choline uptake and phosphatidylcholine synthesis in Chinese hamster ovary cells.

    abstract：:Diethanolamine (DEA), an alkanolamine used widely in industry, is hepatocarcinogenic in mice. The goal of this work was to determine whether DEA altered choline homeostasis in cultured cells, so as to ascertain whether the liver tumor response may be related to choline deficiency. CHO cells were cultured in Ham's F-12...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1253

    authors： Lehman-McKeeman LD,Gamsky EA

    更新日期：1999-09-07 00:00:00

  • A proteomic approach to study Salmonella enterica serovar Typhimurium putative transporter YjeH associated with ceftriaxone resistance.

    abstract：:Mutant 6B7 of Salmonella enterica serovar Typhimurium has a transposon inserted in the putative transporter gene yjeH and shows a more-than-fourfold reduction in resistance to ceftriaxone. In this report we have used proteomic analysis to compare outer membrane protein profiles between this mutant and its parental str...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.07.090

    authors： Hu WS,Lin YH,Shih CC

    更新日期：2007-09-28 00:00:00

  • Secretion of a neuropeptide-metabolizing enzyme similar to endopeptidase 22.19 by glioma C6 cells.

    abstract：:An endopeptidase capable of metabolizing a number of neuropeptides and generating [Met5] and [Leu5] enkephalin from enkephalin-containing peptides is secreted by glioma C6 cells. This neutral endopeptidase that is likely to be a thiol protease, has a Mr of 71KDa and is effective only towards oligopeptides. Its specifi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1213

    authors： Ferro ES,Tambourgi DV,Gobersztejn F,Gomes MD,Sucupira M,Armelin MC,Kipnis TL,Camargo AC

    更新日期：1993-02-26 00:00:00

  • Classification of ADAMTS binding sites: The first step toward selective ADAMTS7 inhibitors.

    abstract：:Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease. In carotid arteries of rats, neointima formation after balloon-mediated injury goes along with enhanced Adamts7 expression. Vice versa, Adamts7-deficient mice display reduced neointima formation following vascular injury. A...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.02.025

    authors： Müller M,Kessler T,Schunkert H,Erdmann J,Tennstedt S

    更新日期：2016-03-11 00:00:00

  • Characterization of the BUD31 gene of Saccharomyces cerevisiae.

    abstract：:A number of genes have been identified in the fully sequenced genome of Saccharomyces cerevisiae that appear to be conserved throughout evolution and the function of which remains poorly understood. In this manuscript we describe the initial characterization of yeast BUD31 gene. cDNA sequences highly related to BUD31 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.228

    authors： Masciadri B,Areces LB,Carpinelli P,Foiani M,Draetta G,Fiore F

    更新日期：2004-08-06 00:00:00

  • Elicitation of metastasis associated protein 2 expression in the phagocytosis by murine testicular Sertoli cells.

    abstract：:Efficient phagocytic clearance of apoptotic spermatogenic cells and residual bodies (RBs) by Sertoli cells (SCs) is crucial for functional mature spermatogenesis. However, little is known about the molecular mechanisms underlying this SCs function. Herein, we reported for the first time that SCs-expressing metastasis ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.02.082

    authors： Zhu CJ,Zhang S,Liang Y,Li W

    更新日期：2014-03-14 00:00:00

  • Quantification of fibronectin as a method to assess ex vivo extracellular matrix remodeling.

    abstract：:Altered architecture, composition and quality of the extracellular matrix (ECM) are pathological hallmarks of several inflammatory and fibro-proliferative pathological processes such as osteoarthritis (OA), rheumatoid arthritis (RA), fibrosis and cancer. One of the most important components of the ECM is fibronectin. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.07.108

    authors： Bager CL,Gudmann N,Willumsen N,Leeming DJ,Karsdal MA,Bay-Jensen AC,Høgdall E,Balslev I,He Y

    更新日期：2016-09-16 00:00:00

  • Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties.

    abstract：:Various methods have been used to evaluate anti-fibrotic activity of drugs. However, most of them are complicated, labor-intensive and lack of efficiency. This study was intended to develop a rapid method for anti-fibrotic drugs screening based on biophysical properties. A549 cells in vitro were stimulated with transf...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.10.127

    authors： Liu M,Zheng M,Xu H,Liu L,Li Y,Xiao W,Li J,Ma E

    更新日期：2015-12-04 00:00:00

  • Protein kinase C binding to isolated nuclei and its activation by a Ca2+/phospholipid-independent mechanism.

    abstract：:The direct interaction of protein kinase C with the nucleus was examined utilizing endogenous protein phosphorylation and [3H]PDBu binding to detect the enzyme. Rat brain nuclei were relatively rich in phorbol ester receptors whereas liver nuclei contained less than 10% of their brain counterpart. Purified protein kin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91030-8

    authors： Misra UK,Sahyoun N

    更新日期：1987-06-15 00:00:00

  • Steroid hormones inhibit binding of Vinca alkaloid to multidrug resistance related P-glycoprotein.

    abstract：:Multidrug-resistant cells are characterized by the presence of P-glycoprotein on the plasma membrane, which binds and probably transports antitumor agents outside the cells. P-glycoprotein is also present in various normal tissues such as the adrenal gland. To investigate the physiological function of P-glycoprotein, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92830-1

    authors： Naito M,Yusa K,Tsuruo T

    更新日期：1989-02-15 00:00:00

  • Differential caspase activity in the cortex and striatum with chronic infusion of 3-nitropropionic acid.

    abstract：:Systemic administration of 3-nitropropionic acid (3-NP) facilitates the development of select striatal lesions, and some reports provide clues about this pathology. In this study, we investigated the relationship between reduced levels of brain-derived neurotrophic factor (BDNF) in lesioned brain regions and caspase a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.08.075

    authors： Cho KJ,Kim GW

    更新日期：2015-09-25 00:00:00

  • Neonatal growth cartilage: equine tissue specific gene expression.

    abstract：:Endochondral bone formation is an important process in development and growth of the skeleton; still many of the mechanisms of growth cartilage remain unknown. The aim of this study was to identify genes specifically expressed in growth cartilage by constructing a subtraction cDNA library of the articular-epiphyseal c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.01.074

    authors： Johannessen MK,Skretting G,Ytrehus B,Røed KH

    更新日期：2007-03-23 00:00:00

  • 20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway.

    abstract：:Ginseng, refering to the roots of the species of the genus Panax ginseng, has been widely used in traditional oriental medicine for its wide spectrum of medicinal effects, such as anti-inflammatory, anti-tumorigenic, adaptogenic, and anti-aging activities. Many of its medicinal effects are attributed to the triterpene...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.08.129

    authors： Min JK,Kim JH,Cho YL,Maeng YS,Lee SJ,Pyun BJ,Kim YM,Park JH,Kwon YG

    更新日期：2006-10-27 00:00:00

  • Two phosphorylation-independent sites on the p85 SH2 domains bind A-Raf kinase.

    abstract：:Src homology 2 (SH2) domains mediate phosphotyrosine (pY)-dependent protein:protein interactions involved in signal transduction pathways. We have found that the SH2 domains of the 85-kDa alpha subunit (p85) of phosphatidylinositol 3-kinase (PI3 kinase) bind directly to the serine/threonine kinase A-Raf. In this repor...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6347

    authors： Fang Y,Johnson LM,Mahon ES,Anderson DH

    更新日期：2002-02-01 00:00:00

  • Chemoenzymic preparation of a glycoconjugate polymer having a sialyloligosaccharide: Neu5Ac alpha (2-->3)Gal beta (1-->4)GlcNAc.

    abstract：:Water-soluble polyacrylamide having 3'-sialyl N-acetyl-lactosamine [Neu5Ac alpha (2-->3)Gal beta (1-->4)GlcNAc] was enzymatically prepared by stepwise sugar-elongation on a water-soluble GlcNAc-bearing polyacrylamide. It was demonstrated that the flexible GlcNAc branches of the polymer chains allow quantitative galact...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1221

    authors： Nishimura S,Lee KB,Matsuoka K,Lee YC

    更新日期：1994-02-28 00:00:00

  • Ubiquitin-conjugating enzyme Cdc34 mediates cadmium resistance in budding yeast through ubiquitination of the transcription factor Met4.

    abstract：:Overexpression of the ubiquitin-conjugating enzyme Cdc34 conferred strong cadmium resistance on budding yeast. Proteasome activity, which is involved in the degradation of ubiquitinated proteins, was not essential for the acquisition of resistance to cadmium. The overexpression of Cdc34 accelerated the ubiquitination ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.09.064

    authors： Hwang GW,Furuchi T,Naganuma A

    更新日期：2007-11-23 00:00:00

  • Silica-induced generation of reactive oxygen species in Rat2 fibroblast: role in activation of mitogen-activated protein kinase.

    abstract：:Exposure to silica has been associated with progressive pulmonary inflammation and fibrosis. While the fibroblasts play an important role in the pathogenesis of silicosis, the direct interaction between silica and fibroblasts is poorly understood. We observed that silica particles stimulated intracellular ROS generati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1274

    authors： Cho YJ,Seo MS,Kim JK,Lim Y,Chae G,Ha KS,Lee KH

    更新日期：1999-09-07 00:00:00