Elicitation of metastasis associated protein 2 expression in the phagocytosis by murine testicular Sertoli cells.


:Efficient phagocytic clearance of apoptotic spermatogenic cells and residual bodies (RBs) by Sertoli cells (SCs) is crucial for functional mature spermatogenesis. However, little is known about the molecular mechanisms underlying this SCs function. Herein, we reported for the first time that SCs-expressing metastasis associated protein 2 (Mta2), a chromatin modifier playing a critical role in modifying DNA accessibility for transcriptional regulation, was steadily up-regulated when SCs were co-cultured with RBs. The most efficient stimulatory substrates for the inducement of phagocytosis-elicited Mta2 expression were RBs and fragments from apoptotic spermatocytes. Furthermore, one major result of this response is the transcriptional repression of follicle-stimulating hormone receptor gene (Fshr) expression during phagocytosis, which should lead to a low level of circulated FSH because effects of FSH on spermatogenesis is fundamentally regulated by the down-regulation of Fshr after exposure to FSH. Given that high concentration of circulated FSH inhibits SCs phagocytic activity and impairment of MTA2 expression is associated with the abnormal high level of serum FSH, our present results suggest that the FSH/MTA2/Fshr cascade may serve as an indispensable negative feedback mechanism to help to maintain low level of circulated FSH, which is required for the normal occurrence of SCs phagocytosis.


Zhu CJ,Zhang S,Liang Y,Li W




Has Abstract


2014-03-14 00:00:00














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    abstract::Several rich sources of polyphenols stimulate the endothelial formation of nitric oxide (NO), a potent vasoprotecting factor, via the redox-sensitive activation of the PI3-kinase/Akt pathway leading to the phosphorylation of endothelial NO synthase (eNOS). The present study examined the molecular mechanism underlying ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Auger C,Kim JH,Chabert P,Chaabi M,Anselm E,Lanciaux X,Lobstein A,Schini-Kerth VB

    更新日期:2010-02-26 00:00:00

  • Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer.

    abstract::MicroRNA (miRNA) plays a pivotal role in cancer biology. Therefore, tumor suppressor (TS) miRNAs are an attractive target for cancer therapy. However, clinical trials have failed due to the difficulties in miRNA delivery, warranting the development of a novel drug delivery system (DDS). Exosomes are stable in circulat...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kobayashi M,Sawada K,Miyamoto M,Shimizu A,Yamamoto M,Kinose Y,Nakamura K,Kawano M,Kodama M,Hashimoto K,Kimura T

    更新日期:2020-06-18 00:00:00

  • Three-hybrid strategy reveals a peptide segment that specifically binds to the 3'-untranslated region of NF-IL6 mRNA.

    abstract::The 3'UTR of eukaryotic mRNA is an important regulation region, on which many trans factors act. In recent years, a series of 3'UTRs were shown to have tumor suppressor function, including the 3'UTR of the human nuclear factor for interleukin-6 (NF-IL6 3'UTR). To understand molecular basis for this function, we have t...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: He YZ,Liu DG

    更新日期:2000-09-16 00:00:00

  • Identification of a novel Ca2+-stimulated S6-kinase in rat liver.

    abstract::Extracellular calcium addition transiently stimulated two S6 peptide kinase activities in isolated rat hepatocytes. Mono Q chromatography revealed that the activities eluting at 0.15 M NaCl and 0.18 M NaCl were stimulated 4-fold and 2-fold, respectively. The kinase stimulated by calcium was a 40000-Mr S6 peptide kinas...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Harlin JC,Tredano M,Rider MH,Bollen M,Chédeville A,Lavoinne A

    更新日期:1997-10-20 00:00:00

  • Automated quantification of FISH signals in urinary cells enables the assessment of chromosomal aberration patterns characteristic for bladder cancer.

    abstract::Targeting the centromeres of chromosomes 3, 7, 17 (CEP3, 7, 17) and the 9p21-locus (LSI9p21) for diagnosing bladder cancer (BC) is time- and cost-intensive and requires a manual investigation of the sample by a well-trained investigator thus overall limiting its use in clinical diagnostics and large-scaled epidemiolog...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Köhler CU,Martin L,Bonberg N,Behrens T,Deix T,Braun K,Noldus J,Jöckel KH,Erbel R,Sommerer F,Tannapfel A,Harth V,Käfferlein HU,Brüning T

    更新日期:2014-06-13 00:00:00

  • Antigen-induced chemokine activation in mouse buccal epithelium.

    abstract::The oral mucosa is an active though poorly understood immunological site. Using an experimental animal system involving antigen priming into the oral mucosa of transgenic mice expressing T cell receptor (TCR) for a peptide antigen of hen-egg lysozyme (HEL), the expression of six chemokine receptors and seven chemokine...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Otten K,Dragoo J,Wang HC,Klein JR

    更新日期:2003-04-25 00:00:00

  • Purification and characterization of proteins with associated tyrosine protein kinase activity from human B lymphocytes.

    abstract::Burkitt lymphoma cells and their counterpart of normal origin contain proteins with associated tyrosine protein, kinase activity. These proteins were isolated by affinity chromatography and Fast Pressure Liquid Chromatography. Proteins with enzyme activity had an app. M. W. of 47 KDa. This protein in extracts of Burki...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Semmel M,Biquard JM,Pavloff N,Hanania N,Gay F

    更新日期:1989-09-15 00:00:00

  • The effect of cannabidiol on mouse hepatic microsomal cytochrome P450-dependent anandamide metabolism.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bornheim LM,Kim KY,Chen B,Correia MA

    更新日期:1993-12-15 00:00:00

  • A mechanism for propagated SOD1 misfolding from frustration analysis of a G85R mutant protein assembly.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Healy EF

    更新日期:2016-09-30 00:00:00

  • Stimulation of Ca2+ release-activated Ca2+ channels as a potential mechanism involved in non-genomic 1,25(OH)2-vitamin D3-induced Ca2+ entry in skeletal muscle cells.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Vazquez G,de Boland AR,Boland R

    更新日期:1997-10-20 00:00:00

  • MicroRNA-185 inhibits the growth and proliferation of osteoblasts in fracture healing by targeting PTH gene through down-regulating Wnt/β -catenin axis: In an animal experiment.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yao CJ,Lv Y,Zhang CJ,Jin JX,Xu LH,Jiang J,Geng B,Li H,Xia YY,Wu M

    更新日期:2018-06-18 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sonobe Y,Liang J,Jin S,Zhang G,Takeuchi H,Mizuno T,Suzumura A

    更新日期:2008-05-23 00:00:00

  • Novel regulation of protein kinase C-η.

    abstract::Protein kinase C (PKC) is the receptor for tumor promoting phorbol esters, which are potent activators of conventional and novel PKCs, but persistent treatment with phorbol esters leads to downregulation of these PKCs. However, PKCη, a novel PKC isozyme, resists downregulation by tumor-promoting phorbol esters, but li...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Pal D,Outram SP,Basu A

    更新日期:2012-09-07 00:00:00

  • Influence of human p16(INK4) and p21(CIP1) on the in vitro activity of recombinant Plasmodium falciparum cyclin-dependent protein kinases.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Li Z,Le Roch K,Geyer JA,Woodard CL,Prigge ST,Koh J,Doerig C,Waters NC

    更新日期:2001-11-16 00:00:00

  • Interaction of casein kinase II with ribosomal protein L22 of Drosophila melanogaster.

    abstract::The ubiquitous eukaryotic protein kinase CKII (casein kinase II) has been found to interact with a number of cellular proteins, either through the catalytic subunit or the regulatory subunit. Using the yeast two-hybrid screening method, we found that the catalytic subunit of Drosophila melanogaster CKII (DmCKII) inter...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhao W,Bidwai AP,Glover CV

    更新日期:2002-10-18 00:00:00

  • Characterization of cDNA for a dehydration-inducible gene that encodes a CLP A, B-like protein in Arabidopsis thaliana L.

    abstract::Sequence was obtained from a cDNA clone, designated ERD1, isolated from a cDNA library of 1-hour-dehydrated plants of Arabidopsis thaliana L. The clone (3150 bp) contains an open reading frame of 946 amino acid residues with greater than 34% sequence identity to the regulatory subunit of the Clp ATP-dependent protease...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kiyosue T,Yamaguchi-Shinozaki K,Shinozaki K

    更新日期:1993-11-15 00:00:00

  • Enzymatic synthesis and characterization of oligosaccharides structurally related to the repeating unit of Pullulan.

    abstract::A trisaccharide (Glcalpha1-4Glcalpha1-6Glc) and a tetrasaccharide (Glcalpha1-4Glcalpha1-4Glcalpha1-6Glc) the structures of which are related to that of repeating unit of pullulan have been obtained, exploiting the transglycolytic activity of Aspergillus niger cyclodextrin glucanotransferase. Both products were obtaine...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Campa C,Vetere A,Gamini A,Donati I,Paoletti S

    更新日期:2002-09-20 00:00:00

  • Rescue of alpha-synuclein cytotoxicity by insulin-like growth factors.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kao SY

    更新日期:2009-07-31 00:00:00

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    abstract::Sequence-specific hybridization of antisense and antigene agent to the target nucleic acid is an important therapeutic strategy to modulate gene expression. However, efficiency of such agents falls due to inherent intramolecular-secondary-structures present in the target that pose competition to intermolecular hybridi...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kaur H,Wengel J,Maiti S

    更新日期:2007-01-05 00:00:00

  • Glucose regulation of CDK7, a putative thiol related gene, in experimental diabetic nephropathy.

    abstract::We previously described the identification of the 3'end of an unknown gene CDK7 using differential display which appeared to be up-regulated in diabetic kidneys [R.A. Page, C.A. Morris, J.D. Williams, C.J. von Ruhland, A.N. Malik, Isolation of diabetes-associated kidney genes using differential display, Biochem. Bioph...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Malik AN,Rossios C,Al-Kafaji G,Shah A,Page RA

    更新日期:2007-05-25 00:00:00

  • Intravenous immunoglobulin enhances the killing activity and autophagy of neutrophils isolated from immunocompromised patients against multidrug-resistant bacteria.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Matsuo H,Itoh H,Kitamura N,Kamikubo Y,Higuchi T,Shiga S,Ichiyama S,Kondo T,Takaori-Kondo A,Adachi S

    更新日期:2015-08-14 00:00:00

  • Changes in ornithine transcarbamylase activity and protein level during perinatal period in rat liver. Effects of actinomycin D.

    abstract::Ornithine transcarbamylase activity and immunoreactive enzyme level are compared during perinatal period and in adult rat. Ornithine transcarbamylase activity regularly rises during late fetal period and presents a marked increase 24 hours after birth. Immunoreactive enzyme level does not correlate with this developme...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Belbekouche M,Gautier C,Vaillant R

    更新日期:1985-06-28 00:00:00

  • MicroRNA-29 regulates myocardial microvascular endothelial cells proliferation and migration in association with IGF1 in type 2 diabetes.

    abstract:BACKGROUND:In our study, we investigated the expression and function of microRNA-29 in myocardial microvascular endothelial cells (MMEVC) in type 2 diabetic Goto-Kakizaki (GK) rats. METHODS:MiR-29 gene expression was compared, by qRT-PCR between diabetic GK rat MMEVC and non-diabetic Wistar rat MMEVC. MiR-29 was downr...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Li Z,Jiang R,Yue Q,Peng H

    更新日期:2017-05-20 00:00:00

  • WITHDRAWN: Novel monoclonal antibody against native cysteine mediated dimer of trimer of HABP1/gC1qR/p32 and its dominance in nucleus.

    abstract::This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Rai V,Datta K

    更新日期:2010-04-10 00:00:00

  • Aggresome formation and pharmacogenetics: sulfotransferase 1A3 as a model system.

    abstract::A common cause for pharmacogenetic alteration in drug response is genetic variation in encoded amino acid sequence. We have used the catecholamine and drug-metabolizing enzyme sulfotransferase (SULT)1A3 to create an artificial model system to study mechanisms-especially possible aggresome formation-by which genetic al...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wang L,Yee VC,Weinshilboum RM

    更新日期:2004-12-10 00:00:00

  • The mechanism of antifungal action of (S)-2-amino-4-oxo-5-hydroxypentanoic acid, RI-331: the inhibition of homoserine dehydrogenase in Saccharomyces cerevisiae.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yamaki H,Yamaguchi M,Imamura H,Suzuki H,Nishimura T,Saito H,Yamaguchi H

    更新日期:1990-04-30 00:00:00

  • Identification of anti-TNFalpha peptides with consensus sequence.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhang J,Zheng L,Zhao A,Gao B,Liu NL,Wang F,Dong J,Xin ZT,Shao NS,Wang HX,Xue YN

    更新日期:2003-10-31 00:00:00

  • High production of type VI collagen in multiple fibromatosis with multiple articular dysplasia.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Murata K,Motoyama T,Suka M,Ohno M,Kuboki Y

    更新日期:1987-08-31 00:00:00

  • ZIFIBI: Prediction of DNA binding sites for zinc finger proteins.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Cho SY,Chung M,Park M,Park S,Lee YS

    更新日期:2008-05-09 00:00:00

  • NMR study of hexanucleotide d(CCGCGG)2 containing two triplet repeats of fragile X syndrome.

    abstract::Long repeated stretches of d(CCG) and tri-nucleotide are crucial mutations that cause hereditary forms of mental retardation (fragile X-syndrome). Moreover, the alternating (CG) di-nucleotide is one of the candidates for Z-DNA conformation. Solution NMR structure of d(CCGCGG)(2) has been solved and is discussed. The d...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Monleón D,Esteve V,Celda B

    更新日期:2003-03-28 00:00:00