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The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2.

Abstract：

:The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (Mpro) and the RNA-dependent RNA polymerase (RdRP), which are responsible for the viral polyprotein proteolytic process and viral genome replication and transcription, respectively, are two attractive drug targets for SARS-CoV-2. This review summarizes up-to-date progress in the structural and pharmacological aspects of those two key targets above. Different classes of inhibitors individually targeting Mpro and RdRP are discussed, which could promote drug development to treat SARS-CoV-2 infection.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Jin Z,Wang H,Duan Y,Yang H

doi

10.1016/j.bbrc.2020.10.091

subject

Has Abstract

pub_date

2020-11-21 00:00:00

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)32018-0

pub_type

杂志文章

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