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Steroid hormones inhibit binding of Vinca alkaloid to multidrug resistance related P-glycoprotein.

Abstract：

:Multidrug-resistant cells are characterized by the presence of P-glycoprotein on the plasma membrane, which binds and probably transports antitumor agents outside the cells. P-glycoprotein is also present in various normal tissues such as the adrenal gland. To investigate the physiological function of P-glycoprotein, we examined possible endogenous materials which inhibit the binding of vincristine to the resistant cell membrane. The binding was inhibited by steroid hormones, most efficiently by progesterone. Progesterone also reduced the photoaffinity labeling of P-glycoprotein by a photoactive analogue of vindesine. These results suggest that P-glycoprotein in the adrenal gland could have a role in the secretion of steroid hormones.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Naito M,Yusa K,Tsuruo T

doi

10.1016/0006-291x(89)92830-1

subject

Has Abstract

pub_date

1989-02-15 00:00:00

pages

1066-71

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92830-1

journal_volume

158

pub_type

杂志文章

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