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Neonatal mortality and leanness in mice lacking the ARID transcription factor Mrf-2.

Abstract：

:Proteins containing the ARID (AT-rich interaction domain) DNA-binding motif regulate gene expression and differentiation in fungi, plants, and animals. This report describes phenotypes resulting from targeted disruption of the ARID gene Mrf-2. Homozygous loss of Mrf-2 resulted in a high rate of neonatal mortality that was partially strain-dependent: survival of Mrf-2(-/-) pups ranged from 6.4% on the 129S1 genetic background to 38% on a mixed 129S1.C57Bl/6J background. Loss of Mrf-2 expression did not affect embryonic survival, embryonic growth or birth weight. Lipid accumulation was severely reduced in brown adipose of Mrf-2(-/-) neonates at 24h of age, however, and Mrf-2(-/-) mice weighed significantly less than controls from postnatal day five onward. Adult Mrf-2(-/-) mice were lean, with significant reductions in brown and white adipose tissues, and in the percentage of body fat. Mrf-2(-/-) and Mrf-2(+/-) mice were also resistant to weight gains and obesity when maintained on high-fat diets. These phenotypes suggest that Mrf-2 is essential for accumulation of lipid stores in postnatal life.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Whitson RH,Tsark W,Huang TH,Itakura K

doi

10.1016/j.bbrc.2003.11.026

subject

Has Abstract

pub_date

2003-12-26 00:00:00

pages

997-1004

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006291X03023763

journal_volume

312

pub_type

杂志文章

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