当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Role of activating transcription factor 3 in low glucose- and thapsigargin-induced apoptosis in cultured mouse islets.

Role of activating transcription factor 3 in low glucose- and thapsigargin-induced apoptosis in cultured mouse islets.

Abstract：

:In vitro, survival and function of rat pancreatic β-cells are optimally preserved in the presence of 10 mmol/l glucose (G10) and markedly altered by prolonged culture at either 2 mmol/l glucose (G2) or 30 mmol/l glucose (G30). The increase in islet cell apoptosis in G2 and G30 vs. G10 is preceded by parallel increases in the mRNA levels of the integrated stress response (ISR) gene activating transcription factor 3 (Atf3) and its putative target and proapoptotic gene growth arrest- and DNA damage-inducible gene 153 (Gadd153/Chop). In this study, we used islets from Atf3 knockout (Atf3(-/-)) mice to test the role of ATF3 in the stimulation of islet cell apoptosis under conditions associated with ISR activation. The glucose sensitivity of Atf3(-/-) and WT islets for the stimulation of insulin secretion and Xbp1 mRNA splicing during 18h culture was similar, demonstrating that glucose metabolism was unaffected by Atf3 deletion. However, the stimulation of islet cell apoptosis by the SERCA pump inhibitor thapsigargin was slightly but significantly reduced in Atf3(-/-) vs. WT islets despite similar level of expression of Gadd153 and Gadd34 mRNA. Also, the stimulation of islet cell apoptosis by 7 days of culture in G2 was slightly but significantly reduced in Atf3(-/-) vs. WT islets, and this effect was accompanied by a significant reduction in Gadd153 mRNA expression. In conclusion, the increase in Atf3 gene expression induced by thapsigargin and low glucose concentrations slightly contributes to the stimulation of islet cell apoptosis under these culture conditions.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Duprez J,Jonas JC

doi

10.1016/j.bbrc.2011.10.048

subject

Has Abstract

pub_date

2011-11-18 00:00:00

pages

294-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)01845-6

journal_volume

415

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells.

    abstract：:Angiogenesis is a key pathogenic event in hepatic fibrogenesis, which is mediated by activated hepatic stellate cells (HSCs). TNP-470 is a known anti-angiogenic agent in cancer, and in this study, we investigated the regulatory mechanisms of TNP-470 blockage of vascular endothelial growth factor (VEGF) synthesis in ac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.175

    authors： Wang YQ,Luk JM,Chu AC,Ikeda K,Man K,Kaneda K,Fan ST

    更新日期：2006-03-03 00:00:00

  • AJAP1 affects behavioral changes and GABABR1 level in epileptic mice.

    abstract：:Adherens junction-associated protein-1 (AJAP1), also called SHREW1, was first discovered as a novel component of adherens junctions in 2004. In later studies, AJAP1 was found to suppress invasion and predict recurrence of some tumors. Apart from its function as a putative tumor suppressor, AJAP1 is still poorly unders...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.036

    authors： Zhang M,Zhou X,Jiang W,Li M,Zhou R,Zhou S

    更新日期：2020-04-16 00:00:00

  • Modulation of rat polymorphonuclear leukocyte 5-lipoxygenase activity by 5-HPETE and NADH-dependent flavin inhibition.

    abstract：:The effect of nicotinamide and flavin coenzymes on the 5-lipoxygenase activity has been determined in cell-free extracts from rat polymorphonuclear leukocytes. 5-lipoxygenase was assayed in the presence of 5-hydroperoxyeicosatetraenoic acid (5-HPETE), which caused a 3 to 4-fold stimulation in the maximal conversion of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80206-6

    authors： Riendeau D,Leblanc Y

    更新日期：1986-12-15 00:00:00

  • Expression of a functional IL-13Ralpha1 by rat B cells.

    abstract：:IL-13 mediates its effects through a complex receptor system including IL-4Ralpha and a functional IL-13Ralpha1. IL-13 has been reported to have no effects on mouse B cells due to a lack of receptor expression. However, on human B cells a functional IL-13Ralpha1 has been described. Here, we identified the rat IL-13Ral...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5682

    authors： Pierrot C,Beniguel L,Bègue A,Khalife J

    更新日期：2001-10-05 00:00:00

  • Inhibitory effect of 11-carbonyl-beta-boswellic acid on non-small cell lung cancer H446 cells.

    abstract：BACKGROUND:The anti-lung tumor potential of 11-carbonyl-β-boswellic acid was investigated. MATERIALS & METHODS:The inhibitory effects of 11-carbonyl-β-boswellic acid on non-small cell lung cancer (NSCLC) was assessed by proliferation, apoptosis, cell cycle and molecular mechanisms in NSCLC H446 cells in vitro. The res...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.137

    authors： Huang G,Yang J,Zhang L,Cao L,Zhang M,Niu X,Zhou Z,Zhang X,Li P,Liu JF

    更新日期：2018-09-18 00:00:00

  • The sequence of sites recognised by a member of the RNase E/G family can control the maximal rate of cleavage, while a 5'-monophosphorylated end appears to function cooperatively in mediating RNA binding.

    abstract：:Members of the RNase E/G family are multimeric, 5'-end-sensing, single-strand-specific endoribonucleases that are found in chloroplasts as well as bacteria, and have central roles in RNA processing and degradation. A well-studied member of this family is Escherichia coli RNase G. Recently, we have shown that the inter...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.11.156

    authors： Jourdan SS,Kime L,McDowall KJ

    更新日期：2010-01-01 00:00:00

  • Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation.

    abstract：:Cathepsin D, a lysosomal aspartic proteinase, has been shown to induce apoptosis of HeLa cells when overexpressed. To further understand regulatory mechanisms of cathepsin D-induced cell death, we examined whether lysosomal cysteine and aspartic proteinases are involved in apoptosis of PC12 cells following serum depri...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9422

    authors： Shibata M,Kanamori S,Isahara K,Ohsawa Y,Konishi A,Kametaka S,Watanabe T,Ebisu S,Ishido K,Kominami E,Uchiyama Y

    更新日期：1998-10-09 00:00:00

  • The role of ELK3 to regulate peritumoral lymphangiogenesis and VEGF-C production in triple negative breast cancer cells.

    abstract：:Tumor-induced lymphangiogenesis, a major conduit for cancer cell dissemination from the primary tumor site to lymph nodes and beyond, eventually leads to metastasis in cancer patients. Given the recent evidence revealing that the suppression of ELK3 inhibits the metastasis of triple-negative breast cancer cells, we ai...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.02.030

    authors： Oh N,Park JI,Park JH,Kim KS,Lee DR,Park KS

    更新日期：2017-03-18 00:00:00

  • CyclinG contributes to G2/M arrest of cells in response to DNA damage.

    abstract：:To investigate regulation mechanisms of G2/M phase transition, we studied the association of cell cycle progression with p53-dependent p21/waf-1 and cyclinG expression. We used doxorubicin (DOX) and sodium butyrate (NaB) to accumulate p53 protein. DOX treatment resulted in an apparent increase of cells in the G2/M fra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.8004

    authors： Shimizu A,Nishida J,Ueoka Y,Kato K,Hachiya T,Kuriaki Y,Wake N

    更新日期：1998-01-26 00:00:00

  • Reprogramming of cancer stem cells into non-tumorigenic cells using stem cell exosomes for cancer therapy.

    abstract：:Cancer stem cells (CSCs) are a small population of cells with stem cell-like properties found in tumors. CSCs are closely associated with tumor heterogeneity, which influences tumor progress, metastasis, and drug resistance. Here, we propose a concept to enhance efficacy of cancer therapy through CSC reprogramming int...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.03.072

    authors： Lee KS,Choi JS,Cho YW

    更新日期：2019-05-07 00:00:00

  • COMP-Ang1 ameliorates leukocyte adhesion and reinforces endothelial tight junctions during endotoxemia.

    abstract：:Endotoxemia is characterized by multiple dysfunctions of the micro-vascular endothelium. Of these, vascular leakage is an initial event that aggravates vascular dysfunction can lead to systemic vascular collapse and organ failure. Thus, prevention of vascular leakage may ameliorate endotoxin-induced dysfunctions of bl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.02.096

    authors： Hwang JA,Lee EH,Lee SD,Park JB,Jeon BH,Cho CH

    更新日期：2009-04-17 00:00:00

  • Inhibition of initiation of simian virus 40 chromosome synthesis by dihydroxyanthraquinone.

    abstract：:The mode of action of dihydroxyanthraquinone, a new antitumor drug, on eucaryotic chromosome structure and function was investigated using simian virus 40 as a model system. Dihydroxyanthraquinone specifically inhibited initiation of viral replicons. Little or no viral DNA synthesis was recovered in cells after the re...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90409-7

    authors： Su RT,Ma XJ,Cheng CC

    更新日期：1985-07-16 00:00:00

  • Kupffer cell-mediated down regulation of rat hepatic CMOAT/MRP2 gene expression.

    abstract：:Lipopolysaccharides (LPS) induces intrahepatic cholestasis and canalicular multispecific organic anion transporter (CMOAT/MRP2) plays a central role in hepatic bilirubin transport. This study examined the role of Kupffer cell in LPS-induced cholestasis. Rats were injected intravenously with LPS. Kupffer cells were ina...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0160

    authors： Nakamura J,Nishida T,Hayashi K,Kawada N,Ueshima S,Sugiyama Y,Ito T,Sobue K,Matsuda H

    更新日期：1999-02-05 00:00:00

  • Follicle-stimulating hormone promotes the transformation of cholesterol to estrogen in mouse adipose tissue.

    abstract：:Follicle-stimulating hormone (FSH) levels increase estrogen biosynthesis in obese menopausal women. Ovariectomized mice and 3T3-L1 cells were used to explore estrogen biosynthesis in the decline of ovarian function. After ovariectomy, lipid deposition, and FSH and estrogen levels changed, and feed intake increased sig...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.12.120

    authors： Cui H,Zhao G,Wen J,Tong W

    更新日期：2018-01-15 00:00:00

  • Effect of botulinum D toxin on neutrophils.

    abstract：:Activated botulinum D toxin ADP-ribosylates a 22 kDa molecular weight protein in homogenates obtained by sonication of a suspension of rabbit peritoneal neutrophils. The ADP-ribosylation catalyzed by activated botulinum D toxin is inhibited in homogenates obtained from cells pretreated with the toxin, suggesting that ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80129-3

    authors： Mege JL,Volpi M,Becker EL,Sha'afi RI

    更新日期：1988-04-29 00:00:00

  • Systemic Klotho therapy protects against insulitis and enhances beta-cell mass in NOD mice.

    abstract：:The levels of the anti-aging protein α-Klotho, in its soluble form (s-Klotho), are depressed in the circulation of patients with type 1 diabetes (T1D) or type 2 diabetes (T2D). Gene transfer experiments have suggested a protective role for β-cell specific expression of α-Klotho in murine models of T1D and T1D, but the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.123

    authors： Prud'homme GJ,Glinka Y,Kurt M,Liu W,Wang Q

    更新日期：2020-05-07 00:00:00

  • Immunocytochemical localization of the Ca2+-ATPase polypeptide in human platelets.

    abstract：:Specific polyclonal antibodies raised against purified human platelet Ca2+-ATPase were used with protein A-gold immunocytochemistry to localize this protein in human platelets. Immunolabeling specifically detected Ca2+-ATPase over the surface connected membrane system (SCS) in sections of paraformaldehyde-fixed, Lowic...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81173-2

    authors： Herbener GH,Dean WL

    更新日期：1988-06-16 00:00:00

  • A faithful method for PCR-mediated global mRNA amplification and its integration into microarray analysis on laser-captured cells.

    abstract：:Quantitative and qualitative analyses of mRNAs from a small number of cells are extremely important for studies on gene expression in various physiological and pathological conditions in multicellular organisms. We present here an effective method for high-fidelity global mRNA amplification for in vivo gene expression...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02967-4

    authors： Aoyagi K,Tatsuta T,Nishigaki M,Akimoto S,Tanabe C,Omoto Y,Hayashi Si,Sakamoto H,Sakamoto M,Yoshida T,Terada M,Sasaki H

    更新日期：2003-01-24 00:00:00

  • A recombinant adenoviral vector encoding functional vasoactive intestinal peptide.

    abstract：:Vasoactive intestinal peptide (VIP) is a small neuropeptide, which exerts pleiotropic functions. Based on its immunomodulatory, secretory, and possibly trophic effects, VIP is a valuable candidate molecule for the management of autoimmune disease. The purpose of this study was to develop a recombinant viral vector cap...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.171

    authors： Lodde BM,Delporte C,Goldsmith CM,Tak PP,Baum BJ

    更新日期：2004-06-18 00:00:00

  • GEFH1 binds ASAP1 and regulates podosome formation.

    abstract：:Invadopodia are cellular structures that are thought to mediate tumor invasion. ASAP1, an Arf GTPase-activating protein (GAP) containing a BAR domain, is a substrate of Src. ASAP1 is required for the assembly of invadopodia and podosomes, which are Src-induced structures related to invadopodia in NIH 3T3 fibroblasts. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.02.093

    authors： Shiba Y,Randazzo PA

    更新日期：2011-03-25 00:00:00

  • Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function.

    abstract：:Malignant human glioma D-298 MG amplifies a rearranged epidermal growth factor receptor (EGFR) gene (c-erbB proto-oncogene), resulting in an in-frame deletion of 83 amino acids in domain IV of the extracellular domain of the EGFR. EGF and transforming growth factor-a (TGF-a) bound to the mutant EGFR with high affinity...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91051-d

    authors： Humphrey PA,Gangarosa LM,Wong AJ,Archer GE,Lund-Johansen M,Bjerkvig R,Laerum OD,Friedman HS,Bigner DD

    更新日期：1991-08-15 00:00:00

  • Procollagen type I C-proteinase enhancer is a naturally occurring connective tissue glycoprotein.

    abstract：:Using antibodies to the procollagen C-proteinase enhancer of mouse fibroblast culture medium, we have screened by immunoblotting extracts of several post natal mouse and rat tissues for the presence of the enhancer antigen. All rodent connective tissues were relatively rich in enhancer; lower amounts were found in ske...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81024-1

    authors： Kessler E,Mould AP,Hulmes DJ

    更新日期：1990-11-30 00:00:00

  • LNA-modified oligonucleotides effectively drive intramolecular-stable hairpin to intermolecular-duplex state.

    abstract：:Sequence-specific hybridization of antisense and antigene agent to the target nucleic acid is an important therapeutic strategy to modulate gene expression. However, efficiency of such agents falls due to inherent intramolecular-secondary-structures present in the target that pose competition to intermolecular hybridi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.10.155

    authors： Kaur H,Wengel J,Maiti S

    更新日期：2007-01-05 00:00:00

  • The ubiquitin-interacting motifs of S5a as a unique upstream inhibitor of the 26S proteasome.

    abstract：:It has been demonstrated that ubiquitin-conjugated proteins were accumulated by ectopically-expressed S5a as well as the ubiquitin-interacting motifs of S5a (S5a-UIMs). In this study, we further found that free S5a-UIMs stabilized only a subset of proteasomal substrates including p53, c-Fos, c-Jun, and p27 but not bet...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.08.078

    authors： Elangovan M,Shin DY,Yoo YJ

    更新日期：2009-10-30 00:00:00

  • Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines.

    abstract：BACKGROUND:Quercetin is a plant polyphenol from the flavonoid group that plays a fundamental role in controlling homeostasis due to its potent antioxidant properties. However, quercetin has extremely low water solubility, which is a major challenge in drug absorption. METHOD:In this study, we described a simple method...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.04.174

    authors： Aghapour F,Moghadamnia AA,Nicolini A,Kani SNM,Barari L,Morakabati P,Rezazadeh L,Kazemi S

    更新日期：2018-06-12 00:00:00

  • Elafin is a potent inhibitor of proteinase 3.

    abstract：:Elafin, a human skin derived inhibitor of human leukocyte elastase, was tested for inhibitory activity against proteinase 3, an elastin degrading proteinase of neutrophils. The inhibitory activity of elafin was compared with antileukoprotease and eglin C. Elafin proved to be a potent inhibitor of elastin-FITC degradat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90476-n

    authors： Wiedow O,Lüademann J,Utecht B

    更新日期：1991-01-15 00:00:00

  • IL-33 signaling fuels outgrowth and metastasis of human lung cancer.

    abstract：:IL-33 is a member of IL-1 superfamily that drives production of Th2-related cytokines. Recently, accumulating evidence suggest an involvement of IL-33 in carcinogenesis. Herein, we determine a close correlation of IL-33 expression and cancer progress in patients with non-small-cell lung cancer (NSCLC). Overexpression ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.09.081

    authors： Wang C,Chen Z,Bu X,Han Y,Shan S,Ren T,Song W

    更新日期：2016-10-21 00:00:00

  • Prompt activation of telomerase by chemical carcinogens in rats detected with a modified TRAP assay.

    abstract：:The maintenance of telomere length is crucial for survival of cells. Telomerase is an RNA-containing reverse transcriptase, which is responsible for elongation of shortened telomeres. Telomerase reactivation has been suggested to be involved in malignant progressions. To study on the involvement of telomerase activati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8487

    authors： Miura M,Karasaki Y,Abe T,Higashi K,Ikemura K,Gotoh S

    更新日期：1998-05-08 00:00:00

  • Cholesterol attenuated the progression of DEN-induced hepatocellular carcinoma via inhibiting SCAP mediated fatty acid de novo synthesis.

    abstract：:Worldwide, hepatocellular carcinoma (HCC) remains a top instigator of cancer mortality. Previous clinical studies have revealed that low serum cholesterol predicts a poor outcome in HCC patients, but the potential role of cholesterol in the progression of HCC remains controversial. In the present study,we tested the i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.12.181

    authors： Zhao Z,Zhong L,He K,Qiu C,Li Z,Zhao L,Gong J

    更新日期：2019-02-19 00:00:00

  • Isolation of two neuropeptides in the AKH/RPCH-family from horseflies (Diptera).

    abstract：:Two neuropeptides (DCCI and DCCII) in the adipokinetic/red pigment concentrating hormone-family have been isolated and purified from the corpora cardiaca of horseflies (Diptera : Tabanidae). Both peptides were purified by a sequence of three reversed phase-high performance liquid chromatographic steps. Amino acid anal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80331-0

    authors： Jaffe H,Raina AK,Fraser BA,Keim P,Rao KR,Zhang YS,Lancaster JL,Hayes DK

    更新日期：1988-03-15 00:00:00