Kupffer cell-mediated down regulation of rat hepatic CMOAT/MRP2 gene expression.

abstract：:Exosomes are 50-100-nm-diameter membrane vesicles released from various types of cells. Exosomes retain proteins, mRNAs and miRNAs, which can be transported to surrounding cells. CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, and is released from the cell surface to the culture medium in vitro. Recentl...

journal_title：Biochemical and biophysical research communications

authors： Sakakura H,Mii S,Hagiwara S,Kato T,Yamamoto N,Hibi H,Takahashi M,Murakumo Y

更新日期：2016-01-22 00:00:00

abstract：:Copper is a micronutrient that is required for proper metabolic functioning of most prokaryotic and eukaryotic organisms. To sustain an adequate supply of copper, a cell requires molecular mechanisms that control the metal content to avoid copper toxicity. This toxicity comes primarily from the reactivity of copper, w...

journal_title：Biochemical and biophysical research communications

authors： Latorre M,Olivares F,Reyes-Jara A,López G,González M

更新日期：2011-03-25 00:00:00

abstract：:The Sf-9 insect cells infected with a recombinant baculovirus integrated with a cDNA encoding human monocyte chemoattractant protein-1 (MCP-1) produced three different MCP-1s, which were isolated by reverse-phase HPLC as 13kDa, 14kDa, and 15kDa bands on SDS-PAGE. The heterogeneity between these MCP-1s was ascribed to ...

journal_title：Biochemical and biophysical research communications

authors： Ishii K,Yamagami S,Tanaka H,Motoki M,Suwa Y,Endo N

更新日期：1995-01-26 00:00:00

abstract：:Circulating hormones are engaged in initiating and controlling the process of spermatogenesis, however, the Sertoli cell tight junctions prevent these substances from directly influencing the spermatogenic cells. Thus, the Sertoli cells play a vital role in regulating the spermatogenic process. Our studies correlate r...

journal_title：Biochemical and biophysical research communications

authors： Page KC,Heitzman DA,Chernin MI

更新日期：1996-05-15 00:00:00

abstract：:The present study investigates the immunomodulatory activities of buckwheat polysaccharide fraction (BPF) from the seed of Fagopyrum esculentum on RAW 264.7 macrophage cell line and Cyclophosphamide-induced immunosuppressed conditions in mice models. The results of in vitro showed that treatment with 0.5-10 μg/mL of B...

journal_title：Biochemical and biophysical research communications

authors： Oh MJ,Choi HD,Ha SK,Choi I,Park HY

更新日期：2018-02-19 00:00:00

abstract：:Purified m beta-acrosin catalysed amidolysis in vitro of several p-nitroanilides with C-terminal arginine residues. alpha 1-proteinase inhibitor inhibited amidolysis catalysed by the enzyme. This effect of alpha 1-Proteinase inhibitor was not prevented by pre-incubation of the enzyme with heparin or any other glycosam...

journal_title：Biochemical and biophysical research communications

authors： Long WF,Williamson FB

更新日期：1983-11-30 00:00:00

abstract：:P-selectin is a cell adhesion molecule found in platelets and endothelial cells mediating binding of leukocytes. It is stored in secretory granules and expressed at the plasma membrane after cell activation. After rapid internalisation P-selectin recycles or is degraded. The 35 amino acid cytoplasmic domain of P-selec...

journal_title：Biochemical and biophysical research communications

authors： Florian V,Schlüter T,Bohnensack R

更新日期：2001-03-09 00:00:00

abstract：:Renal dopamine receptors have been shown to play a critical role in ROS-dependent hypertension. D5 dopamine receptor deficient (D5-/-) mice are hypertensive and have increased systemic oxidative stress which is manifested in the kidney and the brain. To further investigate the underlying mechanisms of hypertension in ...

journal_title：Biochemical and biophysical research communications

authors： Stoelting M,Geyer M,Reuter S,Reichelt R,Bek MJ,Pavenstädt H

更新日期：2009-01-30 00:00:00

abstract：:Cripto is a cell surface protein highly expressed in certain solid tumors, and overexpression of Cripto protein is oncogenic. Cripto-1 protein is encoded by CRIPTO1 gene. CRIPTO3, a presumed pseudogene, has an open reading frame with six amino acid differences from Cripto-1. We show that CRIPTO3 mRNA is the CRIPTO mes...

journal_title：Biochemical and biophysical research communications

authors： Sun C,Orozco O,Olson DL,Choi E,Garber E,Tizard R,Szak S,Sanicola M,Carulli JP

更新日期：2008-12-05 00:00:00

abstract：:In Wernicke's encephalopathy and thiamine deficiency (TD), the cause of this brain disorder, development of inflammation is an important aspect of the disease process. How this pathological mechanism relates to the neurologic impairment associated with TD, however, remains unclear. A key feature of the inflammatory pr...

journal_title：Biochemical and biophysical research communications

authors： Wang D,Hazell AS

更新日期：2010-11-05 00:00:00

abstract：:We have previously shown that estrogen effects in the heart include direct hormone effects on the myocardium. In a recent study we found that one beneficial effect of estradiol on the myocardium is the inhibition of apoptosis in cardiac myocytes. This effect was associated with a reduction of NF-kappaB activity. In th...

journal_title：Biochemical and biophysical research communications

authors： Pelzer T,Neumann M,de Jager T,Jazbutyte V,Neyses L

更新日期：2001-09-07 00:00:00

abstract：:Bovine cytochrome c oxidase in 0.1% dodecylmaltoside, 50 mM KCl and 10 mM Tris-HCl, pH 7.4 is monodisperse with an apparent Mr 360,000 (dimer) as estimated by filtration on Ultrogel AcA 34. In the absence of added KCl the apparent Mr is 160,000 (monomer). The dimeric enzyme has a high and a low affinity site for cytoc...

journal_title：Biochemical and biophysical research communications

authors： Nałecz KA,Bolli R,Azzi A

更新日期：1983-07-29 00:00:00

abstract：:An endonuclease that specifically removes 8-hydroxyguanine (oh8Gua) from DNA has been isolated from Escherichia coli. As the amount of oh8Gua produced in DNA of X-ray-irradiated mice is known to decrease with time after irradiation, an attempt was made to find a similar activity in human polymorphonuclear neutrophils ...

journal_title：Biochemical and biophysical research communications

authors： Chung MH,Kim HS,Ohtsuka E,Kasai H,Yamamoto F,Nishimura S

更新日期：1991-08-15 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a therapeutic target for head and neck squamous cell carcinoma (HNSCC). Here, we evaluated the activity of AZD-2014, a potent mTOR complex 1/2 (mTORC1/2) dual inhibitor, against HNSCC cells. We showed that AZD-2014 blocked mTORC1/2 activation in established and primary human HNS...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Cui JT

更新日期：2016-09-02 00:00:00

abstract：:Despite decades of intensive studies, the failure to identify plasmodesmata (PD) localization sequences has constrained our understanding of Tobacco mosaic virus (TMV) movement. Recently, we identified the first PD localization signal (major PLS) in the TMV movement protein (MP), which encompasses the first 50 amino a...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Huang C,Zeng J,Yu H,Li Y,Yuan C

更新日期：2020-01-01 00:00:00

abstract：:Due to their identical inheritance and shared surroundings, identical twins have been the recommended group for studying the susceptibility and prognosis of diseases. Here, CD8+ T cell receptor beta (TCRβ) chains were analyzed by high-throughput sequencing in three pairs of healthy identical twins and chronic hepatiti...

journal_title：Biochemical and biophysical research communications

authors： Jiang Q,Liu Y,Xu B,Zheng W,Xiang X,Tang X,Dong H,Chen Y,Wang C,Deng G,Mao Q,Shang X,Wu Y

更新日期：2018-02-26 00:00:00

abstract：:Ly6k, a putative mouse glycosylphosphatidyl-inositol (GPI)-anchored membrane protein is specifically associated with a unique germ-cell marker, TEX101. Although a human orthologue LY6K has been proposed as a novel cancer/testis antigen, its molecular nature is largely obscure, because its characteristics have been gle...

journal_title：Biochemical and biophysical research communications

authors： Maruyama M,Yoshitake H,Tsukamoto H,Takamori K,Araki Y

更新日期：2010-11-05 00:00:00

abstract：:Protein phosphatase was partially purified from myofibrils of bovine heart by sequential column chromatographies. The purified protein phosphatase was immunologically identified as a delta isoform of PP1 (PP1delta). The myosin-binding subunit (MBS) of myosin-binding phosphatase (MBP) in smooth muscle was co-purified w...

journal_title：Biochemical and biophysical research communications

authors： Nishio H,Ichikawa K,Hartshorne DJ

更新日期：1997-07-30 00:00:00

abstract：:Bone mass is regulated by various molecules including endogenous factors as well as exogenous factors, such as nutrients and pollutants. Aryl hydrocarbon receptor (AhR) is known as a dioxin receptor and is responsible for various pathological and physiological processes. However, the role of AhR in bone homeostasis re...

journal_title：Biochemical and biophysical research communications

authors： Yu TY,Kondo T,Matsumoto T,Fujii-Kuriyama Y,Imai Y

更新日期：2014-07-18 00:00:00

abstract：:The aim of this study was to investigate the function of miR-183 in renal cancer cells and the mechanisms miR-183 regulates this process. In this study, level of miR-183 in clinical renal cancer specimens was detected by quantitative real-time PCR. miR-183 was up- and down-regulated in two renal cancer cell lines ACHN...

journal_title：Biochemical and biophysical research communications

authors： Qiu M,Liu L,Chen L,Tan G,Liang Z,Wang K,Liu J,Chen H

更新日期：2014-09-12 00:00:00

abstract：:Rheumatoid arthritis (RA) is characterised by chronic inflammation of synovial tissue with aggressive proliferation of synovial cells causing destruction of cartilage and bone. Immunopathological mechanisms, infectious causes and genetic factors have been discussed, but the etiology of the disease has not been underst...

journal_title：Biochemical and biophysical research communications

authors： Mangasser-Stephan K,Dooley S,Welter C,Mutschler W,Hanselmann RG

更新日期：1997-05-08 00:00:00

abstract：:The optical spectrum of Sperm Whale myoglobin, which has been freshly reconstituted with iron protoporphyrin-IX, is shown to be different from that obtained from the native myoglobin, and from the reconstituted, incubated myoglobin (These last two have equivalent absorption spectra). The effect is immediately evident ...

journal_title：Biochemical and biophysical research communications

authors： Gebe JA,Peyton DH,Peyton JA

更新日期：1989-05-30 00:00:00

abstract：:CHFR ubiquitin ligase acts as a checkpoint upon DNA damage and its functional inactivation is one of key characteristics of tumor development and metastasis. Despite the crucial role in maintaining genome integrity and cell cycle progression, little is known how CHFR stability is regulated. Here, we showed that CHFR i...

journal_title：Biochemical and biophysical research communications

authors： Kwon YE,Bae SJ,Kim M,Seol JH

更新日期：2013-01-04 00:00:00

abstract：:The placenta releases syncytiotrophoblast-derived extracellular vesicles (STB-EV) into the maternal circulation throughout gestation. STB-EV dependent signalling is believed to contribute to the widespread maternal adaptive physiological changes seen in pregnancy. Transfer RNA (tRNA) halves have been identified in ves...

journal_title：Biochemical and biophysical research communications

authors： Cooke WR,Cribbs A,Zhang W,Kandzija N,Motta-Mejia C,Dombi E,Ri R,Cerdeira AS,Redman C,Vatish M

更新日期：2019-10-08 00:00:00

abstract：:The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each o...

journal_title：Biochemical and biophysical research communications

authors： Uchida K,Morita T,Sato T,Ogura T,Yamashita R,Noguchi S,Suzuki H,Nyunoya H,Miwa M,Sugimura T

更新日期：1987-10-29 00:00:00

abstract：:Despite the mitochondria ubiquitous nature many of their components display divergences in their expression profile across different tissues. Using the bioinformatics-approach of guilt by association (GBA) we exploited these variations to predict the function of two so far poorly annotated genes: Coiled-coil-helix-coi...

journal_title：Biochemical and biophysical research communications

authors： Martherus RS,Sluiter W,Timmer ED,VanHerle SJ,Smeets HJ,Ayoubi TA

更新日期：2010-11-12 00:00:00

abstract：:A P1 phage clone containing the near complete protein coding region of the human histo-blood group ABO gene locus was isolated and characterized. The insert was estimated at approximately 41 kp, and an approximately 20 kbp BamHI fragment contained the near complete coding region as evaluated by Southern blot analysis....

journal_title：Biochemical and biophysical research communications

authors： Bennett EP,Steffensen R,Clausen H,Weghuis DO,van Kessel AG

更新日期：1995-01-05 00:00:00

abstract：:Why bovine odorant-binding protein (OBPb), among OBP family, assumes a dimeric structure has been unclear. Here we clarified, by measuring the fluorescence of intrinsic tryptophan and tyrosine residues of intact OBPb and OBPb whose C-terminal 10 amino acids were deleted, that odorant enters the central pocket formed b...

journal_title：Biochemical and biophysical research communications

authors： Ikematsu M,Takaoka D,Yasuda M

更新日期：2005-08-12 00:00:00

abstract：:Lysophosphatidyl-L-serine (lysoPS) is thought to be an immunological regulator because it dramatically augments the degranulation of rat peritoneal mast cells (RPMCs). This stimulatory effect may be mediated by a lysoPS receptor, but its molecule has not been identified yet. During a ligand fishing study for the orpha...

journal_title：Biochemical and biophysical research communications

authors： Sugo T,Tachimoto H,Chikatsu T,Murakami Y,Kikukawa Y,Sato S,Kikuchi K,Nagi T,Harada M,Ogi K,Ebisawa M,Mori M

更新日期：2006-03-24 00:00:00

abstract：:Several rat liver cytochromes P-450 have been substantially purified in a one-step immunoadsorption procedure using Sepharose-bound monoclonal antibodies (MAbs) to the major forms of rat liver cytochrome P-450 induced by 3-methylcholanthrene and phenobarbital (MC-P-450 and PB-P-450, respectively). When mixed with solu...

journal_title：Biochemical and biophysical research communications

authors： Friedman FK,Robinson RC,Park SS,Gelboin HV

更新日期：1983-11-15 00:00:00