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Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function.

Abstract：

:Malignant human glioma D-298 MG amplifies a rearranged epidermal growth factor receptor (EGFR) gene (c-erbB proto-oncogene), resulting in an in-frame deletion of 83 amino acids in domain IV of the extracellular domain of the EGFR. EGF and transforming growth factor-a (TGF-a) bound to the mutant EGFR with high affinity and enhanced the intrinsic mutant EGFR kinase activity. The mutant EGFR was capable of transducing EGF-stimulated glioma cell proliferation and invasiveness in an in vitro three-dimensional spheroid model. The deletion-mutant EGFR in D-298 MG is capable of being activated by growth factor; this suggests that overexpression of this mutant EGFR protein rather than structural alteration may be the more significant biologic event.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Humphrey PA,Gangarosa LM,Wong AJ,Archer GE,Lund-Johansen M,Bjerkvig R,Laerum OD,Friedman HS,Bigner DD

doi

10.1016/0006-291x(91)91051-d

subject

Has Abstract

pub_date

1991-08-15 00:00:00

pages

1413-20

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)91051-D

journal_volume

178

pub_type

杂志文章

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