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The C-terminal tail of protein kinase D2 and protein kinase D3 regulates their intracellular distribution.

Abstract：

:We generated a set of GFP-tagged chimeras between protein kinase D2 (PKD2) and protein kinase D3 (PKD3) to examine in live cells the contribution of their C-terminal region to their intracellular localization. We found that the catalytic domain of PKD2 and PKD3 can localize to the nucleus when expressed without other kinase domains. However, when the C-terminal tail of PKD2 was added to its catalytic domain, the nuclear localization of the resulting protein was inhibited. In contrast, the nuclear localization of the CD of PKD3 was not inhibited by its C-terminal tail. Furthermore, the exchange of the C-terminal tail of PKD2 and PKD3 in the full-length proteins was sufficient to exchange their intracellular localization. Collectively, these data demonstrate that the short C-terminal tail of these kinases plays a critical role in determining their cytoplasmic/nuclear localization.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Papazyan R,Rozengurt E,Rey O

doi

10.1016/j.bbrc.2006.02.013

subject

Has Abstract

pub_date

2006-04-14 00:00:00

pages

685-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00292-0

journal_volume

342

pub_type

杂志文章

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