Comprehensive investigation of aberrant microRNAs expression in cells culture model of MnCl2-induced neurodegenerative disease.

abstract：:Phenobarbital (PB) increases metabolic capability of hepatocytes by its ability to activate numerous genes encoding various xenochemical-metabolizing enzymes such as cytochrome P450s and specific transferases. More than 35 years since PB induction was first reported, the key nuclear receptor CAR that mediates the indu...

journal_title：Biochemical and biophysical research communications

authors： Zelko I,Negishi M

更新日期：2000-10-14 00:00:00

abstract：:The prevalence of nonalcoholic fatty liver disease (NAFLD) is high and increasing throughout the world. The intense sterile inflammation stemming from steatosis plays a significant role in the development of NAFLD, but the mechanism is unclear. We found that the NLRC4 inflammasome was activated in an in vitro cell mod...

journal_title：Biochemical and biophysical research communications

authors： Chen Y,Ma K

更新日期：2019-04-09 00:00:00

abstract：:The abnormal deposition of amyloid beta peptide (Abeta) is a hallmark of Alzheimer's disease (AD). Phospholipase C-delta1 (PLC-delta1) is also known to abnormally accumulate in the brains of AD patients, but no report has addressed the relationship between these two events. This study investigated the effect of Abeta4...

journal_title：Biochemical and biophysical research communications

authors： Kim JY,Kim H,Lee SG,Choi BH,Kim YH,Huh PW,Lee KH,Han H,Rha HK

更新日期：2003-10-24 00:00:00

abstract：:S100A8 and S100A9 are members of the S100A8 protein family that exist as homodimers and heterodimers in neutrophils, monocytes, and macrophages. Recent studies have shown the pivotal roles of S100A8 and S100A9 in the propagation of inflammation and keratinocyte proliferation in psoriasis. We found significant up-regul...

journal_title：Biochemical and biophysical research communications

authors： Lee Y,Jang S,Min JK,Lee K,Sohn KC,Lim JS,Im M,Lee HE,Seo YJ,Kim CD,Lee JH

更新日期：2012-07-13 00:00:00

abstract：:During IFN alpha stimulation, p59(fyn) associates with the Type I IFNR-associated Tyk-2 kinase in several human hematopoietic cell lines in vivo. This interaction is direct, and is mediated by the SH2 domain in p59(fyn), as shown by binding studies using glutathione-S-transferase fusion proteins and far western blots....

journal_title：Biochemical and biophysical research communications

authors： Uddin S,Sher DA,Alsayed Y,Pons S,Colamonici OR,Fish EN,White MF,Platanias LC

更新日期：1997-06-09 00:00:00

abstract：:Little is known about the gene expression in human oocytes and early embryo development because of the rare availability of the materials. The recent advancement of biotechnology has allowed one to analyze the gene expression in single human oocytes and preimplantation embryos. Gene expression of human lactate dehydro...

journal_title：Biochemical and biophysical research communications

authors： Li SS,Liu YH,Tseng CN,Singh S

更新日期：2006-02-03 00:00:00

abstract：:Binding of phorbol-12,13-dibutyrate (PDBu), a tumor promoter, to quiescent Swiss 3T3 cells increased the number of hexose carriers, resulting in stimulation of membrane transport of 3-O-methylglucose (3MeGlu) in a Ca2+-dependent fashion. Extracellular Ca2+ was necessary to initiate the binding of PDBu to its receptor,...

journal_title：Biochemical and biophysical research communications

authors： Kitagawa K,Nishino H,Iwashima A

更新日期：1985-04-16 00:00:00

abstract：:We have purified from beef liver an enzyme which decarbamoylates carbamoyl-hemoglobin and to a much lesser extent carbamoyl histones. Carbamoyl casein was a poor substrate while carbamoyl trypsin, fibrinogen and ovoalbumin were not affected. The optimal pH is 7.4. Addition of Mg++, Mn++ or Ca++ was without effect. On ...

journal_title：Biochemical and biophysical research communications

authors： Costell M,Grisolía S

更新日期：1985-04-16 00:00:00

abstract：:The production of therapeutic monoclonal antibodies is costly; therefore, antigen-binding fragments (Fabs) can be used instead. However, their tendency toward aggregation can reduce the half-life in the plasma and the therapeutic effectiveness. To examine the effect of glycosylation on the properties of the Fab of a t...

journal_title：Biochemical and biophysical research communications

authors： Nakamura H,Oda-Ueda N,Ueda T,Ohkuri T

更新日期：2018-09-05 00:00:00

abstract：:Asialofetuin-tacked liposomes (AF-liposomes) encapsulating interferon (IFN)-gamma were bound and internalized into a human hepatoma cell line, HepG2 cells, selectively through asialoglycoprotein receptor, but not non-tacked liposomes (N-liposomes). AF-liposomal IFN-gamma was more effective for inhibition of viral DNA ...

journal_title：Biochemical and biophysical research communications

authors： Ishihara H,Hayashi Y,Hara T,Aramaki Y,Tsuchiya S,Koike K

更新日期：1991-01-31 00:00:00

abstract：:Chloroperoxidase was present as Compound II during the peroxidatic oxidation of ascorbic acid. Compound III (oxy-form) was formed when excess hydrogen peroxide was added to Compound II. By decreasing the temperature it was possible to measure the spectra of Compounds II and III in the Soret and visible regions. Each s...

journal_title：Biochemical and biophysical research communications

authors： Nakajima R,Yamazaki I,Griffin BW

更新日期：1985-04-16 00:00:00

abstract：:Cell-free translation is one potential approach to the production of functional transmembrane proteins. We have now examined various detergents as supplements to a wheat-germ cell-free system in order to optimize the production and subsequent purification of a functional model transmembrane protein, bacteriorhodopsin....

journal_title：Biochemical and biophysical research communications

authors： Genji T,Nozawa A,Tozawa Y

更新日期：2010-10-01 00:00:00

abstract：:The crystal structure of the mu and kappa opioid receptors has revealed dimeric structural arrangements. Mu-delta receptors heteromers also exist and we have identified discrete cytoplasmic regions in each receptor required for oligomer formation. In the carboxyl tail of the delta receptor we identified three glycine ...

journal_title：Biochemical and biophysical research communications

authors： O'Dowd BF,Ji X,O'Dowd PB,Nguyen T,George SR

更新日期：2012-06-15 00:00:00

abstract：:In this study, the full-length cDNA of the UDP-glucose pyrophosphorylase gene was isolated from jute by homologous cloning (primers were designed according to the sequence of UGPase gene of other plants) and modified RACE techniques; the cloned gene was designated CcUGPase. Using bioinformatic analysis, the gene was i...

journal_title：Biochemical and biophysical research communications

authors： Zhang G,Qi J,Xu J,Niu X,Zhang Y,Tao A,Zhang L,Fang P,Lin L

更新日期：2013-12-13 00:00:00

abstract：:Epidermal growth factor (EGF) enhances the induction of alpha-lactalbumin in mammary explants from pregnant and virgin rats in the presence of insulin (I), hydrocortisone (F) and prolactin (P). EGF also enhances the prolactin-independent induction of alpha-lactalbumin in tissue from pregnant rats and evokes prolactin-...

journal_title：Biochemical and biophysical research communications

authors： Sankaran L,Topper YJ

更新日期：1983-12-16 00:00:00

abstract：:We examined the expression of a Caenorhabditis elegans (C. elegans) elav-like gene, which we designated elr-1. The elr-1 gene encodes a predicted 456-amino-acid protein containing three putative RNA-binding domains and belongs to the ELAV family, which is functionally involved in neuronal differentiation. Northern blo...

journal_title：Biochemical and biophysical research communications

authors： Fujita M,Kawano T,Ohta A,Sakamoto H

更新日期：1999-07-14 00:00:00

abstract：:Cell adhesion molecules act as tumor suppressors primarily by cell attachment activity, but additional mechanisms modifying signal transduction are suggested in some cases. Cell adhesion molecule 1 (CADM1), a membrane-spanning immunoglobulin superfamily, mediates intercellular adhesion by trans-homophilic interaction ...

journal_title：Biochemical and biophysical research communications

authors： Tsuboi Y,Oyama M,Kozuka-Hata H,Ito A,Matsubara D,Murakami Y

更新日期：2020-08-27 00:00:00

abstract：:Calmodulin activation of target enzymes depends on the interaction between calmodulin hydrophobic regions and some enzyme areas. The Ca2+ induced exposure of calmodulin hydrophobic sites was studied by means of 2-p-toluidinylnaphthalene-6-sulfonate, a fluorescent probe. Scatchard and Job plots showed that the calmodul...

journal_title：Biochemical and biophysical research communications

authors： Follenius A,Gerard D

更新日期：1984-03-30 00:00:00

abstract：:There is a major unmet medical need for effective and well tolerated treatment options for cancer. The search now seeks to identify active biomolecules with multiple targets. Lupeol, an important dietary triterpenoid known as anticarcinogen by inducing apoptosis. But it is still more to reveal the potency of lupeol in...

journal_title：Biochemical and biophysical research communications

authors： Vijay Avin BR,Prabhu T,Ramesh CK,Vigneshwaran V,Riaz M,Jayashree K,Prabhakar BT

更新日期：2014-05-30 00:00:00

abstract：:Thyrotropin receptor (TSHR) in extrathyroidal tissue, especially fat tissue, is supposed to have important roles in the development of extrathyroidal manifestations of Graves' disease. However, the molecular mechanism of TSHR expression is not known. Expression of TSHR mRNA and TSH-dependent cAMP production were obser...

journal_title：Biochemical and biophysical research communications

authors： Haraguchi K,Shimura H,Lin L,Saito T,Endo T,Onaya T

更新日期：1996-06-05 00:00:00

abstract：:Protein folding continues to be an important biophysical topic in molecular biology. We report the parameters for successfully refolding the guanylyl cyclase core of the ANP receptor, an allosteric homodimeric enzyme. Urea was a better chaotropic solvent than guanidine HCl, and physiological salt concentrations and pH...

journal_title：Biochemical and biophysical research communications

authors： Thorpe DS,Niu S,Morkin E

更新日期：1996-07-25 00:00:00

abstract：:Isoprenoids comprise a diverse group of natural products with a broad range of metabolic functions. Isoprenoids are synthesized from prenyl pyrophosphates by prenyltransferases that catalyze the isoprenoid chain-elongation process to different chain lengths. We hereby present the crystal structure of geranylgeranyl py...

journal_title：Biochemical and biophysical research communications

authors： Kim S,Kim EJ,Park JB,Kim SW,Kim KJ

更新日期：2019-10-20 00:00:00

abstract：:Transglutaminase 2 (TGase 2) is a bifunctional enzyme that catalyzes calcium-dependent transamidation and GTP binding/hydrolysis. The transamidation activity is proposed to be associated with several neurodegenerative disorders such as Alzheimer's and Hungtinton's disease. However, the regulation mechanism by which TG...

journal_title：Biochemical and biophysical research communications

authors： Jeon JH,Cho SY,Kim CW,Shin DM,Kweon JC,Choi KH,Park SC,Kim IG

更新日期：2002-06-21 00:00:00

abstract：:Mechanical loading of cultured mesangial cells has been shown to induce both increased production of matrix proteins and cell proliferation. This in vitro phenomenon has been implicated in the progression of glomerular sclerosis observed in a variety of glomerular diseases. However, it is not yet known how cells sense...

journal_title：Biochemical and biophysical research communications

authors： Hamasaki K,Mimura T,Furuya H,Morino N,Yamazaki T,Komuro I,Yazaki Y,Nojima Y

更新日期：1995-07-17 00:00:00

abstract：:The mammalian-target-of-rapamycin (mTOR) is a multidomain protein that is important in regulating several components of the translational machinery. mTOR signalling is stimulated by hormones (e.g., insulin) and by amino acids. Our recent data suggest that TOR signalling responds to intracellular amino acids rather tha...

journal_title：Biochemical and biophysical research communications

authors： Proud CG

更新日期：2004-01-09 00:00:00

abstract：:Trp140 of E. coli aspartate aminotransferase has been converted to Phe or Gly by site-directed mutagenesis. As compared to the wild-type enzyme, either of the mutant enzymes showed 10- to 100-fold increase in Km's for natural dicarboxylic substrates, but did not show appreciable changes in Km's for aromatic substrates...

journal_title：Biochemical and biophysical research communications

authors： Hayashi H,Inoue Y,Kuramitsu S,Morino Y,Kagamiyama H

更新日期：1990-03-16 00:00:00

abstract：:Intestinal N-acetylglucosamine 6-O-sulfotransferase (I-GlcNAc6ST, GST-4alpha) and corneal N-acetylglucosamine 6-O-sulfotransferases (C-GlcNAc6ST, GST-4beta) are two highly homologous GlcNAc 6-O-sulfotransferase isozymes encoded by two intronless open reading frames that reside approximately 50 kb apart on human chromo...

journal_title：Biochemical and biophysical research communications

authors： Bartes A,Bhakta S,Hemmerich S

更新日期：2001-04-13 00:00:00

abstract：:The activation of caspase-3 is a key surrogate marker for detecting apoptosis. To quantitate caspase-3 activity, we constructed a biosensor comprising a recombinant firefly luciferase containing a caspase-3 cleavage site. When apoptosis was induced, caspase-3 cleavage of the biosensor activated firefly luciferase by a...

journal_title：Biochemical and biophysical research communications

authors： Shi J,Zhang H,Fang L,Xi Y,Zhou Y,Luo R,Wang D,Xiao S,Chen H

更新日期：2014-10-03 00:00:00

abstract：:Specific anatomical sites and pathways responsible for mediating metabolic and neuroendocrine effects of leptin are still poorly understood. Therefore, we examined distribution of leptin receptor-containing neurons transsynaptically connected with the porcine fat tissue by means of combined viral transneuronal tracing...

journal_title：Biochemical and biophysical research communications

authors： Czaja K,Kraeling RR,Barb CR

更新日期：2003-11-14 00:00:00

abstract：:We reported that ganglioside GD3 enhances cell proliferation and invasion of melanomas causing stronger tyrosine-phosphorylation of p130Cas and paxillin after stimulation with fetal calf serum. Besides signals via growth factor/receptor, adhesion signals via integrin might be also enhanced by GD3. Here, roles of integ...

journal_title：Biochemical and biophysical research communications

authors： Ohkawa Y,Miyazaki S,Miyata M,Hamamura K,Furukawa K,Furukawa K

更新日期：2008-08-15 00:00:00