当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin.

S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin.

Abstract：

:S100A8 and S100A9 are members of the S100A8 protein family that exist as homodimers and heterodimers in neutrophils, monocytes, and macrophages. Recent studies have shown the pivotal roles of S100A8 and S100A9 in the propagation of inflammation and keratinocyte proliferation in psoriasis. We found significant up-regulation of S100A8 and S100A9 secretion from keratinocytes in psoriatic lesions. To mimic the in vivo secretory conditions of S100A8 and S100A9 from psoriatic epidermal keratinocytes, we used the culture medium (CM) of S100A8 and S100A8/A9 adenovirus-transduced keratinocytes to investigate the functions of S100A8 and S100A9. We detected increased levels of various pro-inflammatory cytokines in the CM, including IL-8 and TNF-α, which are involved in aggravating psoriatic skin lesions, and IL-6 and members of the CXCL family of pro-angiogenic cytokines. The CM increased immune cell migration and increased angiogenesis in human umbilical vein endothelial cells. In conclusion, we found that the upregulated production of S100A8 and S100A9 by psoriatic epidermal keratinocytes activated adjacent keratinocytes to produce several cytokines. Moreover, S100A8 and S100A9 themselves function as pro-angiogenic and chemotactic factors, generating a psoriatic milieu in skin.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lee Y,Jang S,Min JK,Lee K,Sohn KC,Lim JS,Im M,Lee HE,Seo YJ,Kim CD,Lee JH

doi

10.1016/j.bbrc.2012.05.162

subject

Has Abstract

pub_date

2012-07-13 00:00:00

pages

647-53

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)01070-4

journal_volume

423

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Reduced phosphorylcholine hydrolysis by homogenates of temporal regions of Alzheimer's brain.

    abstract：:The hydrolysis of p-nitrophenylphosphorylcholine, p-nitrophenylphosphate, and phosphorylcholine was quantitated in homogenates prepared from the occipital and temporal regions of control and Alzheimer's Disease patient brain. There were no significant differences detected in activities of enzymes cleaving the first 2 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80115-2

    authors： Kanfer JN,McCartney DG

    更新日期：1986-08-29 00:00:00

  • Genistein, a tyrosine kinase inhibitor, blocks the cell cycle progression but not Ca2+ influx induced by BAY K8644 in FRTL-5 cells.

    abstract：:IGF-I, when added to TSH-primed FRTL-5 cells, induces a long lasting Ca2+ influx and then DNA synthesis. Ca2+ channel agonist, BAYK 8644, is capable to mimic these effects on cell proliferation. We studied the effect of genistein, a specific tyrosine kinase inhibitor, on BAY K8644- or IGF-I- induced cell cycle progres...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1120

    authors： Takano T,Takada K,Tada H,Nishiyama S,Amino N

    更新日期：1993-02-15 00:00:00

  • Co-culture of endothelial cells and patterned smooth muscle cells on titanium: construction with high density of endothelial cells and low density of smooth muscle cells.

    abstract：:Endothelialization has been considered a promising method to improve the biocompatibility of vascular implanted biomaterials. However, little is known about the anti-coagulation, anti-inflammatory, anti-atherosclerosis and anti-shedding property of the attached endothelial cells (ECs) and the relationship with their b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.10.127

    authors： Li J,Zhang K,Wu J,Liao Y,Yang P,Huang N

    更新日期：2015-01-09 00:00:00

  • Retinoic acid signaling regulates embryonic clock hairy2 gene expression in the developing chick limb.

    abstract：:Embryo development proceeds under strict temporal control and an embryonic molecular clock (EC), evidenced by cyclic gene expression, is operating during somite formation and limb development, providing temporal information to precursor cells. In somite precursor cells, EC gene expression and periodicity depends on Re...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.06.077

    authors： Sheeba CJ,Palmeirim I,Andrade RP

    更新日期：2012-07-13 00:00:00

  • A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain.

    abstract：:Lymphokine and hematopoietic growth factors control the differentiation and proliferation of diverse cell types by binding to specific cell-surface receptors. Strikingly, the recently elucidated sequences of the interleukin-6 and erythropoietin receptors, and the interleukin-2 receptor beta-chain (p75), display a sign...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91528-3

    authors： Bazan JF

    更新日期：1989-10-31 00:00:00

  • Self-assembly formed by a short DNA probe pair: Application for highly sensitive mRNA species detection without reverse transcription.

    abstract：:We describe a novel technology for detecting nucleic acids: Probe Alteration Link Self-Assembly Reactions (PALSAR). PALSAR comprises DNA self-assembly of pairs of short DNA probes formed by alternate hybridization of three complementary regions in a pair of honeycomb probes (HCPs). Self-assembly occurs at designated s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.10.019

    authors： Usui M,Fujikawa T,Osawa M,Hakii C,Ikumi N,Nozaki T,Kitamura N,Hatta Y,Fujiwara S,Takei M

    更新日期：2015-11-27 00:00:00

  • Activation of (Na+ + K+)-ATPase induces positive inotropy in intact mouse heart in vivo.

    abstract：OBJECTIVE:We have recently identified an activation site on (Na+ + K+)-ATPase and found that binding of antibody SSA412 to this specific site of the enzyme markedly augments (Na+ + K+)-ATPase catalytic activity. Demonstration of whether activation of (Na+ + K+)-ATPase affects heart function in animal in vivo was the ob...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.08.070

    authors： Xu KY,Takimoto E,Fedarko NS

    更新日期：2006-10-20 00:00:00

  • Anti-apoptotic peptides protect against radiation-induced cell death.

    abstract：:The risk of terrorist attacks utilizing either nuclear or radiological weapons has raised concerns about the current lack of effective radioprotectants. Here it is demonstrated that the BH4 peptide domain of the anti-apoptotic protein Bcl-xL can be delivered to cells by covalent attachment to the TAT peptide transduct...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.01.180

    authors： McConnell KW,Muenzer JT,Chang KC,Davis CG,McDunn JE,Coopersmith CM,Hilliard CA,Hotchkiss RS,Grigsby PW,Hunt CR

    更新日期：2007-04-06 00:00:00

  • Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway.

    abstract：:We have previously shown that sphingosine 1-phosphate (S1P) stimulates motility of human umbilical vein endothelial cells (HUVECs) (O.-H. Lee et al., Biochem. Biophys. Res. Commun. 264, 743-750, 1999). To investigate the molecular mechanisms by which S1P stimulates HUVEC motility, we examined tyrosine phosphorylation ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2087

    authors： Lee OH,Lee DJ,Kim YM,Kim YS,Kwon HJ,Kim KW,Kwon YG

    更新日期：2000-02-05 00:00:00

  • Receptor-mediated formation of multilayer aggregates of primary cultured adult rat hepatocytes on lactose-substituted polystyrene.

    abstract：:We used a lactose-substituted polystyrene, poly-N-p-vinylbenzyl-D-lactonamide (PVLA), as a substratum for adult rat hepatocytes in primary culture. Spherical-shaped hepatocytes attached on PVLA substratum formed stable multilayer aggregates anchored on substratum through the stimulation of epidermal growth factor (EGF...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91182-p

    authors： Tobe S,Takei Y,Kobayashi K,Akaike T

    更新日期：1992-04-15 00:00:00

  • Deletion of OSH3 gene confers resistance against ISP-1 in Saccharomyces cerevisiae.

    abstract：:Sphingolipids have been reported to regulate the growth and death of mammalian and yeast cells, but their precise mechanisms are unknown. In this paper, it was shown that the deletion of the oxysterol binding protein homologue 3 (OSH3) gene confers hyper resistance against ISP-1, an inhibitor of sphingolipid biosynthe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.01.039

    authors： Yano T,Inukai M,Isono F

    更新日期：2004-02-27 00:00:00

  • Promoter analysis of interleukin 19.

    abstract：:Interleukin (IL)-19 belongs to the IL-10 family which includes IL-19, IL-20, IL-22, AK155, and MDA-7. IL-10 is a potent immunomodulatory cytokine with implications for pathogenesis in various autoimmune diseases. Polymorphism of the IL-10 promoter region correlates with disease outcome. To understand the gene regulati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.03.200

    authors： Chen PJ,Wei CC,Wang C,Chen FW,Hsu YH,Chang MS

    更新日期：2006-06-09 00:00:00

  • The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication.

    abstract：:The 2',3'-dideoxyriboside of 2,6-diaminopurine (ddDAPR) and its 2',3'-didehydro derivative (ddeDAPR) are poor substrates for adenosine deaminase (ADA) but potent inhibitors of the enzyme. Their Km values for ADA are of the same order of magnitude as those of the natural adenosine (Ado) and 2'-deoxyadenosine (dAdo), bu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91317-9

    authors： Balzarini J,Robins MJ,Zou RM,Herdewijn P,De Clercq E

    更新日期：1987-05-29 00:00:00

  • Sequence and tissue distribution of a candidate G-coupled receptor cloned from rat hypothalamus.

    abstract：:We have used RT-PCR with degenerate transmembrane primers to clone members of the G-coupled protein receptor family from rat hypothalamic suprachiasmatic nuclei. We report here a novel clone, UHR-1, which encodes a candidate receptor that is most similar to the neuropeptide receptor family, including the tachykinins, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1543

    authors： Welch SK,O'Hara BF,Kilduff TS,Heller HC

    更新日期：1995-04-17 00:00:00

  • Localization of alpha-inhibin-31 in rodent testis and brain by immunocytochemical procedure and Western blot analysis.

    abstract：:Using an anti-serum against synthetic alpha-inhibin-31, we have studied its cellular locations in rodent testis and brain. Western blot analysis detected several molecular forms of the protein(s). A protein of 17 KDa in size was detected in testis of one month old mice. Two major bands of molecular weights 39 kDA and ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91290-3

    authors： Lau YF,Li CH

    更新日期：1987-05-29 00:00:00

  • Tissue distribution and characterization of prorenin-converting enzyme in mouse.

    abstract：:Renin is produced from an inactive precursor, prorenin, through endoproteolytic cleavage at paired basic amino-acid residues. Using (35S)methionine-labeled prorenin, that was synthesized with Xenopus oocyte expression system, as a substrate, we have determined the tissue distribution and the nature of prorenin-convert...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(89)80057-9

    authors： Nakayama K,Kim WS,Hatsuzawa K,Hashiba K,Murakami K

    更新日期：1989-01-31 00:00:00

  • Participation of cysteine 30 residue in the folding process of ovalbumin evaluated in a refolding experiment using cysteine mutants.

    abstract：:To understand the role of cysteine (SH) residues in the folding of hen ovalbumin (OVA), SH-mutated OVAs, in which each SH residue was replaced by alanine (C11A, C30A, C367A, and C382A), were prepared. SDS-PAGE analysis under non-reducing conditions showed that the C11A and C30A mutants produced a disulfide (SS) isomer...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.11.146

    authors： Ishimaru T,Ito K,Tanaka M,Matsudomi N

    更新日期：2018-01-01 00:00:00

  • Nearest neighbour algorithm for predicting protein subcellular location by combining functional domain composition and pseudo-amino acid composition.

    abstract：:In this paper, based on the approach by combining the "functional domain composition" [K.C. Chou, Y. D. Cai, J. Biol. Chem. 277 (2002) 45765] and the pseudo-amino acid composition [K.C. Chou, Proteins Struct. Funct. Genet. 43 (2001) 246; Correction Proteins Struct. Funct. Genet. 2044 (2001) 2060], the Nearest Neighbou...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00775-7

    authors： Cai YD,Chou KC

    更新日期：2003-05-30 00:00:00

  • Novel fibroblast growth factor 2 transcripts are expressed in mouse embryos.

    abstract：:We have discovered two new exons in the mouse fibroblast growth factor 2 (FGF-2 or bFGF) gene that can be alternatively spliced to the second coding exon of the gene. The newly identified exons 1b and 1c are located at, respectively, approximately 19 and 32 kb downstream of the canonical exon 1a. Using RT-PCR analysis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5683

    authors： Dirks RP,Potter SJ,Griep AE

    更新日期：2001-10-05 00:00:00

  • DRG: a novel developmentally regulated GTP-binding protein.

    abstract：:Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein. The predicted protein of 4...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91567-a

    authors： Sazuka T,Tomooka Y,Ikawa Y,Noda M,Kumar S

    更新日期：1992-11-30 00:00:00

  • Camptothecin and Zeocin can increase p53 levels during all cell cycle stages.

    abstract：:The ability of DNA damage to stabilize p53 in all cell cycle stages has not been examined in actively growing cells. The chemotherapeutic drug camptothecin is a topoisomerase I poison. Zeocin is a member of the bleomycin/phleomycin family of antibiotics, known to bind DNA. Both increase the level of p53 albeit by diff...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.6073

    authors： Houser S,Koshlatyi S,Lu T,Gopen T,Bargonetti J

    更新日期：2001-12-21 00:00:00

  • Functional analysis of isoflavones using patient-derived human colonic organoids.

    abstract：:Inflammatory bowel disease (IBD) comprises two major subtypes, ulcerative colitis (UC) and Crohn's disease, which are multifactorial diseases that may develop due to genetic susceptibility, dysbiosis, or environmental factors. Environmental triggers of IBD include food-borne factors, and a previous nationwide survey i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2021.01.021

    authors： Tsuchiya M,Ito G,Hama M,Nagata S,Kawamoto A,Suzuki K,Shimizu H,Anzai S,Takahashi J,Kuno R,Takeoka S,Hiraguri Y,Sugihara HY,Mizutani T,Yui S,Oshima S,Tsuchiya K,Watanabe M,Okamoto R

    更新日期：2021-01-20 00:00:00

  • The N588K-HERG K+ channel mutation in the 'short QT syndrome': mechanism of gain-in-function determined at 37 degrees C.

    abstract：:The idiopathic short QT syndrome (SQTS) is characterised by an abnormally short QT interval on the electrocardiogram and by an increased risk of arrhythmia and sudden death. One variant of the syndrome is linked to missense mutations that lead to a single amino-acid change (N588K; asparagine to lysine) in the S5-Pore ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.06.112

    authors： McPate MJ,Duncan RS,Milnes JT,Witchel HJ,Hancox JC

    更新日期：2005-08-26 00:00:00

  • Synthesis of a new cell penetrating calpain inhibitor (calpeptin).

    abstract：:N-terminal of Leu-norleucinal or Leu-methioninal was modified to obtain a cell penetrative peptide inhibitor against calpain. Benzyloxycarbonyl (Z) derivatives had less active against papain than phenylbutyryl derivatives and leupeptin. Z-Leu-nLeu-H (calpeptin) was more sensitive to calpain I than Z-Leu-Met-H and leup...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81355-x

    authors： Tsujinaka T,Kajiwara Y,Kambayashi J,Sakon M,Higuchi N,Tanaka T,Mori T

    更新日期：1988-06-30 00:00:00

  • DNA polymerase epsilon from Drosophila melanogaster.

    abstract：:We identified a DNA polymerase species in Drosophila melanogaster embryos, and purified it. This polymerase shared some common properties with DNA polymerase epsilon from mammals and yeast as follows; it has a preference for poly(dA)/oligo(dT) as a template/primer, it is highly processive in DNA synthesis, it co-fract...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.5945

    authors： Aoyagi N,Oshige M,Hirose F,Kuroda K,Matsukage A,Sakaguchi K

    更新日期：1997-01-13 00:00:00

  • Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer.

    abstract：:Mammary gland-distributed and ER-bound UDP-glucuronosyltransferase (UGT)-2B7 metabolizes genotoxic catechol-estrogens (CE) associated with breast cancer initiation. Although UGT2B7 has 3 PKC- and 2 tyrosine kinase (TK)-sites, its inhibition by genistein, herbimycin-A and PP2 with parallel losses in phospho-tyrosine an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.03.054

    authors： Mitra PS,Basu NK,Owens IS

    更新日期：2009-05-15 00:00:00

  • Transcriptional downregulation of sterol metabolism genes in murine liver exposed to acute hypobaric hypoxia.

    abstract：:Ascent to high-altitude results in decreased inspired partial pressure of oxygen because of a decrease in barometric pressure. Altitude acclimatization requires physiological and metabolic changes to improve tolerance to altitude hypoxia. Cellular response to hypoxia results into changes in the profile of gene express...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.159

    authors： Dolt KS,Karar J,Mishra MK,Salim J,Kumar R,Grover SK,Qadar Pasha MA

    更新日期：2007-03-02 00:00:00

  • Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay.

    abstract：:Glycated insulin was evaluated in plasma and biological tissues of diabetic animal models by immunocytochemistry (ICC) and a novel radioimmunoassay. Glycated insulin circulated at 0.10 +/- 0.04 ng/ml and 2.20 +/- 0.14 ng/ml in lean and diabetic obese (ob/ob) mice, corresponding to 12.5 and 9.8% total plasma insulin, r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5447

    authors： McKillop AM,Mooney MH,Harriott P,Flatt PR,O'Harte FP

    更新日期：2001-08-24 00:00:00

  • The protective effect of tetrahydrobiopterin on the nitric oxide-mediated inhibition of purified nitric oxide synthase.

    abstract：:The nitric oxide synthases (NOS) are a class of enzymes responsible for the generation of NO via an oxygen and NADPH dependent oxidation of the amino acid arginine. These enzymes are ironheme proteins which contain FAD and FMN and, enigmatically, require tetrahydrobiopterin (BH4). NOS has recently been shown to be sub...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1052

    authors： Hyun J,Komori Y,Chaudhuri G,Ignarro LJ,Fukuto JM

    更新日期：1995-01-05 00:00:00

  • Detection of cannabinoid receptors by photoaffinity labelling.

    abstract：:A novel [125I]-labelled photoaffinity ligand designed to detect cannabinoid binding sites has been used in mouse brain preparations and in cultured S49 mouse lymphoma cells. The ligand, 2-iodo-5'-azido-delta 8-THC, shows a high affinity for sites in both brain (Kd = 5.60 pM) and whole cell (Kd = 9.38 pM) systems. Phot...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90951-3

    authors： Burstein SH,Audette CA,Charalambous A,Doyle SA,Guo Y,Hunter SA,Makriyannis A

    更新日期：1991-04-15 00:00:00