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Camptothecin and Zeocin can increase p53 levels during all cell cycle stages.

Abstract：

:The ability of DNA damage to stabilize p53 in all cell cycle stages has not been examined in actively growing cells. The chemotherapeutic drug camptothecin is a topoisomerase I poison. Zeocin is a member of the bleomycin/phleomycin family of antibiotics, known to bind DNA. Both increase the level of p53 albeit by different mechanisms. We have utilized centrifugal elutriation to separate exponentially growing ML-1 cells (containing wild-type p53) into cell cycle fractions and have subsequently treated these cells with the two drugs. We provide evidence that both drugs can mediate an increase in p53 protein levels independent of the cell cycle stage. The p53 induced by both drugs was able to bind to DNA; however, only the p53 induced by camptothecin was phosphorylated at serine-392. This is the first demonstration that camptothecin and Zeocin can differentially signal for increased levels of modified p53 during all stages of the cell cycle.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Houser S,Koshlatyi S,Lu T,Gopen T,Bargonetti J

doi

10.1006/bbrc.2001.6073

subject

Has Abstract

pub_date

2001-12-21 00:00:00

pages

998-1009

issue

5

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(01)96073-5

journal_volume

289

pub_type

杂志文章

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