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An investigation of genomic base distribution.

Abstract：

:While veritable oceans of ink have been spilled over the base distributions within genes, the literature is virtually silent on large scale intra genomic base distribution. To address this issue, we have examined approximately 3400 chromosomal sequences from approximately 2000 entire genomes-including DNA and RNA, single- and double-stranded, coding and non-coding genomes. For each sequence the mean, variance, skewness, and kurtosis for each base were computed along with the genome base composition. The main findings are: (1) there is no simple relationship between these statistics and the base composition of the genome, (2) in non-viral genomes, base distribution is non-uniform, (3) base distribution in non-eukaryotic genomes obeys a number of simple rules, (4) these rules are not dependent on the presence of coding sequences, (5) bacterial genomes in particular are unusually compliant with these rules, and (6) eukaryotes have a unique pattern of base distribution.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mitchell D,Bridge R

doi

10.1016/j.bbrc.2006.03.182

subject

Has Abstract

pub_date

2006-06-02 00:00:00

pages

612-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00715-7

journal_volume

344

pub_type

杂志文章

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