当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Chronic administration of ezetimibe increases active glucagon-like peptide-1 and improves glycemic control and pancreatic beta cell mass in a rat model of type 2 diabetes.

Chronic administration of ezetimibe increases active glucagon-like peptide-1 and improves glycemic control and pancreatic beta cell mass in a rat model of type 2 diabetes.

Abstract：

:Ezetimibe is a cholesterol-lowering agent targeting Niemann-Pick C1-like 1, an intestinal cholesterol transporter. Inhibition of intestinal cholesterol absorption with ezetimibe may ameliorate several metabolic disorders including hepatic steatosis and insulin resistance. In this study, we investigated whether chronic ezetimibe treatment improves glycemic control and pancreatic beta cell mass, and alters levels of glucagon-like peptide-1 (GLP-1), an incretin hormone involved in glucose homeostasis. Male LETO and OLETF rats were treated with vehicle or ezetimibe (10 mg kg(-1)day(-1)) for 20 weeks via stomach gavage. OLETF rats were diabetic with hyperglycemia and significant decreases in pancreatic size and beta cell mass compared with LETO lean controls. Chronic treatment of OLETF rats with ezetimibe improved glycemic control during oral glucose tolerance test compared with OLETF controls. Moreover, ezetimibe treatment rescued the reduced pancreatic size and beta cell mass in OLETF rats. Interestingly, ezetimibe significantly decreased serum dipeptidyl peptidase-4 activity and increased serum active GLP-1 in OLETF rats without altering serum total GLP-1. These findings demonstrated that chronic administration of ezetimibe improves glycemic control and pancreatic beta cell mass, and increases serum active GLP-1 levels, suggesting possible involvement of GLP-1 in the ezetimibe-mediated beneficial effects on glycemic control.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yang SJ,Choi JM,Kim L,Kim BJ,Sohn JH,Kim WJ,Park SE,Rhee EJ,Lee WY,Oh KW,Park SW,Kim SW,Park CY

doi

10.1016/j.bbrc.2011.02.129

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

153-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)00348-2

journal_volume

407

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Characterization of multiple fumarase proteins in Escherichia coli.

    abstract：:Two different types of fumarase were found in sonic extracts of Escherichia coli; one required Fe-S for the enzyme activity, and the other did not. When the cells were grown without aeration, the Fe-S-independent enzyme occupied over 80% of the overall fumarase activity. Highly purified Fe-S-independent enzyme was sug...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81360-3

    authors： Yumoto N,Tokushige M

    更新日期：1988-06-30 00:00:00

  • The level of a transcription factor Sp1 is correlated with the expression of EGF receptor in human gastric carcinomas.

    abstract：:The expression of the transcription factor Sp1 and EGF receptor (EGFR) was examined on human gastric carcinoma cell lines and gastric carcinoma tissues as well as corresponding normal mucosa in order to clarify the mechanism of overexpression of EGFR gene without gene amplification. All 7 carcinoma cell lines expresse...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90221-6

    authors： Kitadai Y,Yasui W,Yokozaki H,Kuniyasu H,Haruma K,Kajiyama G,Tahara E

    更新日期：1992-12-30 00:00:00

  • Inflammatory effect of endosulfan via NF-kappaB activation in macrophages.

    abstract：:Macrophages are essential for the inflammatory response process because they release a wide variety of proinflammatory mediators. Endosulfan is extremely toxic to invertebrates and has been implicated in various mammalian toxicities. However, its influence on production of cytokine or on the functions of macrophages i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.01.062

    authors： Han EH,Hwang YP,Kim HG,Jeong HG

    更新日期：2007-04-20 00:00:00

  • Cbl regulates the activity of SIRT2.

    abstract：:SIRT2 is a member of the sirtuin family of NAD(+)-dependent protein deacetylases. It is involved in metabolic homeostasis and has been linked to the progression of age-related diseases. Casitas B-lineage lymphoma (Cbl) proteins regulate signal transduction through many pathways and, consequently, regulate cell functio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.09.125

    authors： Choi YH,Kim H,Han Y,Jin YH,Lee KY

    更新日期：2014-10-24 00:00:00

  • Violacein inhibits matrix metalloproteinase mediated CXCR4 expression: potential anti-tumor effect in cancer invasion and metastasis.

    abstract：:Matrix metalloproteinases (MMP-2 and -9) play an important role in the tumor metastasis through cleavage of proinflammatory cytokines. Violacein a small molecule produced by Chromobacterium violaceum and has been implicated with anti-cancer effects. In this study we investigated the molecular basis of violacein mediat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.10.124

    authors： Platt D,Amara S,Mehta T,Vercuyssee K,Myles EL,Johnson T,Tiriveedhi V

    更新日期：2014-12-05 00:00:00

  • Exercise maintains blood-brain barrier integrity during early stages of brain metastasis formation.

    abstract：:Tumor cell extravasation into the brain requires passage through the blood-brain barrier, which is a highly protected microvascular environment fortified with tight junction (TJ) proteins. TJ integrity can be regulated under physiological and pathophysiological conditions. There is evidence that exercise can modulate ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.04.153

    authors： Wolff G,Davidson SJ,Wrobel JK,Toborek M

    更新日期：2015-08-07 00:00:00

  • Molecular cloning and RNA expression of two new human chemokine receptor-like genes.

    abstract：:Two new human genes encoding putative G protein-coupled receptors were cloned from genomic DNA following a degenerate PCR strategy. The predicted amino acid sequences of the proteins encoded by these genes have the characteristic motifs of chemokine receptors. This prompted us to name these genes CKR-L1 and CKR-L3. Ne...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1595

    authors： Zaballos A,Varona R,Gutiérrez J,Lind P,Márquez G

    更新日期：1996-10-23 00:00:00

  • K-rasG12V mediated lung tumor models identified three new quantitative trait loci modifying events post-K-ras mutation.

    abstract：:A high incidence of oncogenic K-ras mutations is observed in lung adenocarcinoma of human cases and carcinogen-induced animal models. The process of oncogenic K-ras-mediated lung adenocarcinogenesis can be dissected into two parts: pre- and post-K-ras mutation. Adoption of transgenic lines containing a flox-K-rasG12V ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.09.052

    authors： Saito H,Suzuki N

    更新日期：2014-10-03 00:00:00

  • An artificial six-zinc finger peptide with polyarginine linker: selective binding to the discontinuous DNA sequences.

    abstract：:Artificial DNA binding peptides recognizing separated sequences would expand varieties of the target genes for desirable transcriptional control. Here we demonstrated that polyarginine linker between two 3-zinc finger domains gives DNA binding selectivity to the separated target sequences. We created a six-zinc finger...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.05.090

    authors： Imanishi M,Yan W,Morisaki T,Sugiura Y

    更新日期：2005-07-22 00:00:00

  • Isozyme analysis of human polymorphonuclear leukocyte phosphofructokinase from insulin resistant individuals.

    abstract：:Phosphofructokinase (PFK) from human polymorphonuclear leukocytes (PMN) was characterized by immunological titration with subunit specific antibodies and column chromatography on QAE-Sephadex in three different groups: control, type II diabetic, and obese individuals. It was found that PMN phosphofructokinase in the t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1281

    authors： Durante P,Raleigh X,Gómez ME,Campos G,Ryder E

    更新日期：1996-08-23 00:00:00

  • Quinqueginsin, a novel protein with anti-human immunodeficiency virus, antifungal, ribonuclease and cell-free translation-inhibitory activities from American ginseng roots.

    abstract：:A homodimeric protein designated quinqueginsin, with a molecular weight of 53 kDa, has been isolated from the roots of American ginseng Panax quinquefolium. It was unadsorbed on DEAE cellulose in low ionic strength and neutral pH, and adsorbed on Affigel blue gel and SP-Sepharose under similar conditions. Its N-termin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2114

    authors： Wang HX,Ng TB

    更新日期：2000-03-05 00:00:00

  • Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces cardiac fibroblast proliferation by suppressing GATA Binding Protein 4.

    abstract：:Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and GATA Binding Protein 4 (GATA4) are important for the growth of cardiac fibroblasts (CFs). When deregulated, LOX-1 and GATA4 can cause cardiac remodeling. In the present study, we found novel evidence that GATA4 was required for the LOX-1 regulation of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.05.095

    authors： Liu B,Liu NN,Liu WH,Zhang SW,Zhang JZ,Li AQ,Liu SM

    更新日期：2016-07-08 00:00:00

  • Monocarboxylate transporters in breast cancer and adipose tissue are novel biomarkers and potential therapeutic targets.

    abstract：:Monocarboxylate transporters (MCTs) are transmembrane proteins that control the lactate metabolism and associated with poor prognosis in solid tumours including breast cancer (BC). This study aimed to evaluate the clinical and prognostic value of MCTs used by immunohistochemistry and quantum dots-based fluorescent ima...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.05.091

    authors： Li Z,Wu Q,Sun S,Wu J,Li J,Zhang Y,Wang C,Yuan J,Sun S

    更新日期：2018-07-02 00:00:00

  • Transposon-independent increase of transcription by the Sleeping Beauty transposase.

    abstract：:When a plasmid encoding the Sleeping Beauty (SB) transposase (pCMV-SB) was cointroduced with luciferase expression plasmid DNA into mouse skeletal muscle at a molar ratio of 4:1, luciferase gene expression was 5 times higher than the expression without pCMV-SB on day 28. This enhancement was not dependent on the prese...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.116

    authors： Masuda K,Yamamoto S,Endoh M,Kaneda Y

    更新日期：2004-05-07 00:00:00

  • The membrane integration of a naturally occurring alpha-helical hairpin.

    abstract：:Helical hairpins, two closely spaced helical membrane spanning segments separated by a short surface turn, are thought to be common in integral membrane proteins. Here, we study the membrane integration of a naturally occurring helical hairpin from the secretory Na(+)-K(+)-2Cl(-) cotransporter NKCC1. This sequence is ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.02.149

    authors： Nagy A,Turner RJ

    更新日期：2007-05-04 00:00:00

  • Both the PH domain and N-terminal region of oxysterol-binding protein related protein 8S are required for localization to PM-ER contact sites.

    abstract：:Oxysterol-binding protein-related proteins are implicated in the sensing and transporting lipids at the membrane contact sites. One of the members of the mammalian ORP family, ORP8, is thought to transport lipids through directly tethering both ER and PM membranes. Targeting to PM is thought to be mediated by N-termin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.01.138

    authors： Lee M,Fairn GD

    更新日期：2018-02-19 00:00:00

  • Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum.

    abstract：:Myocardial stunning (temporary post-ischaemic contractile dysfunction) may be caused by oxidative stress and/or impaired myocyte calcium homeostasis. Regional myocardial stunning was induced in open-chest pigs (segment shortening reduced to 68.3+/-4.7% of baseline) by repetitive brief circumflex coronary occlusion (I/...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.06.115

    authors： Kumar S,Hall RJ,Mani AR,Moore KP,Camici PG,Rimoldi OE,Williams AJ,Macleod KT

    更新日期：2009-09-11 00:00:00

  • Immunological and conformation characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease.

    abstract：:The immunological recognition pattern of one of the most commonly used monoclonal antibodies, PHF-1, which detects the paired helical filaments of Alzheimer's disease, exhibits a high degree of similarity with the recognition of a polyclonal antibody, anti-T3P, raised against a synthetic phosphopeptide, GAEIVYKS(Phosp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91264-q

    authors： Lang E,Szendrei GI,Lee VM,Otvos L Jr

    更新日期：1992-09-16 00:00:00

  • Phenobarbital and some other liver tumor promoters stimulate DNA synthesis in cultured rat hepatocytes.

    abstract：:Hepatocytes isolated from normal adult rats were maintained at sub-confluent density in a defined medium in primary culture. In control cultures with added epidermal growth factor and low concentrations of dexamethasone, the rate of DNA synthesis was initially low but increased after about 30 hours in culture. Additio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91776-0

    authors： Edwards AM,Lucas CM

    更新日期：1985-08-30 00:00:00

  • Neurotensin receptors on the rat liver plasma membranes.

    abstract：:Neurotensin (NT) is now classified as a brain-gut peptide in the central nervous system and gastrointestinal tract. In the present study, we characterized the NT receptors on the rat liver plasma membranes. The specific binding of [3H]NT was time dependent, reversible, and saturable. Scatchard analysis of the specific...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91546-4

    authors： Muraki K,Nishi Y,Arai M,Kubo N,Ueda K,Shikata H,Nakata Y,Segawa T,Yanaihara N,Yajima H

    更新日期：1987-06-30 00:00:00

  • Two domains in alpha interferons influence the efficacy of the antiviral response.

    abstract：:Murine interferon-alpha 1 and murine interferon-alpha 4 share 80% of their amino acids, yet the proteins differ considerably in their ability to protect mouse or hamster cells against viral infection. With the aim of localizing areas within these proteins which influence the biological response we have constructed hyb...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80085-2

    authors： Zwarthoff EC,Gennissen A,Bosveld IJ,Trapman J,van Heuvel M

    更新日期：1987-08-31 00:00:00

  • Afrikander cattle congenital goiter: size heterogeneity in thyroglobulin mRNA.

    abstract：:The mRNA coding for thyroglobulin in cattle homozygous for an autosomal recessive defect of thyroglobulin synthesis was investigated using a recombinant plasmid containing bovine mRNA coding sequence. Total RNA preparations from goiter contained one third of the thyroglobulin mRNA sequences found in normal thyroid tis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90597-2

    authors： Ricketts MH,Vandenplas S,van der Walt M,van Jaarsveld PP,Bester AJ,Boyd CD

    更新日期：1985-01-16 00:00:00

  • Age-dependent decrease of carnitine content in muscle of mice and humans.

    abstract：:Carnitine deficiency associated with impairment of muscle function has been described in infants and young adults as a result of inherited or acquired disease but there are no reports on carnitine levels in healthy aging people. In this paper we show a marked reduction of carnitine and its derivatives in muscle, and o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91360-0

    authors： Costell M,O'Connor JE,Grisolía S

    更新日期：1989-06-30 00:00:00

  • Endothelin stimulates accumulations of cellular atrial natriuretic peptide and its messenger RNA in rat cardiocytes.

    abstract：:The effect of endothelin-1 (ET-1) on secretion and synthesis of rat atrial natriuretic peptide (rANP) as well as its mRNA levels was studied in primary cultures of neonatal rat atrial cardiocytes. ET-1 dose-dependently (10(-10)-10(-7) M) increased media and cellular rANP-like immunoreactivity as well as its cytoplasmi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91830-5

    authors： Fukuda Y,Hirata Y,Taketani S,Kojima T,Oikawa S,Nakazato H,Kobayashi Y

    更新日期：1989-11-15 00:00:00

  • Ligand interaction scan (LIScan) in the study of ERK8.

    abstract：:ERK8 is the most recent addition for the MAPK family, and its mechanism of activation and function are not yet known, mainly due to the lack of any known physiological stimulator. In this report, we describe the preparation of reagents for the use of a novel method, the ligand interaction scan (LIScan), to study the f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.07.029

    authors： Erster O,Seger R,Liscovitch M

    更新日期：2010-08-13 00:00:00

  • Biochemical characterization of the phagocytic giant cell receptor for Dictyostelium discoideum amoebae: identification by cell blotting.

    abstract：:A critical aspect of sexual development in Dictyostelium is the selection of "self" as a targeted food source by the phagocytic zygotic giant cell (ZGC). It has previously been demonstrated that phagocytic giant cells preferentially take up amoebae of the same species suggesting that the process is mediated by a speci...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.5990

    authors： Lewis KE,Jamieson JC

    更新日期：1997-01-23 00:00:00

  • Class specific peptide inhibitors for secretory phospholipases A2.

    abstract：:Phospholipases A2 (PLA2) catalyze the hydrolytic cleavage of free fatty acids from the sn-2 OH-moiety of glycerophospholipids. These enzymes have a number of functions, from digestion to signaling and toxicity of several venoms. They have also been implicated in inflammation and are connected to diverse diseases, such...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.05.110

    authors： Mahalka AK,Kinnunen PK

    更新日期：2013-06-28 00:00:00

  • Murine leukemia virus particles activate Rac1 in HeLa cells.

    abstract：:A number of viruses, when they bind to cells, activate intracellular signals that facilitate post-binding steps of infection. To determine if retroviruses activate intracellular signaling, we transduced HeLa cells with amphotropic retroviruses produced by TelCeB6 cells and examined cell lysates for activated Rac1. We ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.05.027

    authors： Krishna D,Le Doux JM

    更新日期：2006-07-07 00:00:00

  • microRNA-183 plays as oncogenes by increasing cell proliferation, migration and invasion via targeting protein phosphatase 2A in renal cancer cells.

    abstract：:The aim of this study was to investigate the function of miR-183 in renal cancer cells and the mechanisms miR-183 regulates this process. In this study, level of miR-183 in clinical renal cancer specimens was detected by quantitative real-time PCR. miR-183 was up- and down-regulated in two renal cancer cell lines ACHN...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.08.067

    authors： Qiu M,Liu L,Chen L,Tan G,Liang Z,Wang K,Liu J,Chen H

    更新日期：2014-09-12 00:00:00

  • The dsRNA-mimetic poly (I:C) and IL-18 synergize for IFNgamma and TNFalpha expression.

    abstract：:Interleukin (IL)-18 bioactivity and dsRNA sensing by receptors of innate immunity are key components of anti-viral host defense. Despite extensive data on signal transduction activated by both pathways knowledge on cross-communication is incomplete. By using human PBMC and predendritic KG1 cells, as prototypic IL-18-r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.09.040

    authors： Balah A,Akool el-S,Bachmann M,Pfeilschifter J,Mühl H

    更新日期：2009-11-27 00:00:00