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Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway.

Abstract：

:The Wnt signaling pathway is crucial for development and disease. The regulation of Wnt protein trafficking is one of the pivotal issues in the Wnt research field. Here we performed a genetic screen in Drosophila melanogaster for genes involved in Wingless/Wnt secretion, and identified the p24 protein family members Baiser, CHOp24, Eclair and a v-SNARE protein Sec22, which are involved in the early secretory pathway of Wingless/Wnt. We provided genetic evidence demonstrating that loss of p24 proteins or Sec22 impedes Wingless (Wg) secretion in Drosophila wing imaginal discs. We found that Baiser cannot replace other p24 proteins (CHOp24 or Eclair) in escorting Wg, and only Baiser and CHOp24 interact with Wg. Moreover, we showed that the v-SNARE protein Sec22 and Wg are packaged together with p24 proteins. Taken together, our data provide important insights into the early secretory pathway of Wg/Wnt.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Li X,Wu Y,Shen C,Belenkaya TY,Ray L,Lin X

doi

10.1016/j.bbrc.2015.04.151

subject

Has Abstract

pub_date

2015-08-07 00:00:00

pages

483-9

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)00958-4

journal_volume

463

pub_type

杂志文章

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