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Identification of DLK1 variants in pituitary- and neuroendocrine tumors.

Abstract：

:In a gene chip analysis of common pituitary tumor types, one of the genes with the most impressive tissue-specific expression regulation was delta-like 1 (DLK1), which was strongly expressed in GH-secreting (GH-S) pituitary tumors. In addition to pituitary adenomas, various endocrine tumors were subjected to real-time-quantitative PCR revealing high expression of DLK1 in normal pituitary tissue, in GH-S-, in one prolactin-secreting pituitary adenoma and in pheochromocytomas. Additionally, three DLK1 gene-derived subvariants were identified. The first, lacking 204 bp--coding for epidermal growth factor-like domain 6 and parts of the juxtamembrane region--was named Secredeltin. In the other two splice variants (named Brevideltin and Brevideltinin), a stop codon is introduced due to a frame-shift, leading to truncated proteins of 204 and 213 aas, respectively.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Altenberger T,Bilban M,Auer M,Knosp E,Wolfsberger S,Gartner W,Mineva I,Zielinski C,Wagner L,Luger A

doi

10.1016/j.bbrc.2005.12.094

subject

Has Abstract

pub_date

2006-02-17 00:00:00

pages

995-1005

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)02813-5

journal_volume

340

pub_type

杂志文章

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