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Poly-L-lysine dissolves fibrillar aggregation of the Alzheimer beta-amyloid peptide in vitro.

Abstract：

:beta-Amyloid peptide (beta A) is a major fibrillar component of neuritic plaques in Alzheimer's disease (AD) brains and is related to the pathogenesis of the disease. In this study, using electron microscopy, we describe herein the results concerning the efficacy of compounds that can dissolve preformed beta A fibrils in vitro. For such a purpose, two hydrosoluble and biocompatible polymers such as polyethylene glycol and poly-L-lysine were used. The poly-L-lysine appears as a potent dissolver of preformed beta A fibrils in vitro. Its efficiency is instantaneous. Poly-L-lysine can be used as a universal dissolver of all types of oligomeric beta-sheet conformation, precursor of the fibrils. This finding provides the basis for future investigation of the therapeutic potential of poly-L-lysine in terms of preventing and/or retarding amyloidogenesis in AD and other types of amyloid-related disorders.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nguyen KV,Gendrault JL,Wolff CM

doi

10.1006/bbrc.2002.6514

subject

Has Abstract

pub_date

2002-03-08 00:00:00

pages

764-8

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006291X02965149

journal_volume

291

pub_type

杂志文章

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