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The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes.

Abstract：

:NDC1 is a transmembrane nucleoporin that is required for NPC assembly and nucleocytoplasmic transport. We show here that NDC1 directly interacts with the nucleoporin ALADIN, mutations of which are responsible for triple-A syndrome, and that this interaction is required for targeting of ALADIN to nuclear pore complexes (NPCs). Furthermore, we show that NDC1 is required for selective nuclear import. Our findings suggest that NDC1-mediated localization of ALADIN to NPCs is essential for selective nuclear protein import, and that abrogation of the interaction between ALADIN and NDC1 may be important for the development of triple-A syndrome.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamazumi Y,Kamiya A,Nishida A,Nishihara A,Iemura S,Natsume T,Akiyama T

doi

10.1016/j.bbrc.2009.08.096

subject

Has Abstract

pub_date

2009-11-06 00:00:00

pages

100-4

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01675-1

journal_volume

389

pub_type

杂志文章

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