K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711.

abstract：:In order to understand the molecular basis for antiprogestin action, we have compared the interaction of the antiprogestin [3H]RU38, 486 (RU486) and the progestin [3H]R5020 with the progesterone receptor (PR). In both MCF-7 and T47D human breast cancer cells, we have observed marked differences in the sedimentation pr...

journal_title：Biochemical and biophysical research communications

authors： Mullick A,Katzenellenbogen BS

更新日期：1986-02-26 00:00:00

abstract：:The responsiveness of the human mammary carcinoma cell line MCF-7 to estradiol and tamoxifen treatment has been studied in different culture conditions. Cells from exponentially growing cultures were compared with cells in their initial cycles after replating from confluent cultures ("confluent-log" cells). It has bee...

journal_title：Biochemical and biophysical research communications

authors： Jozan S,Faye JC,Tournier JF,Tauber JP,David JF,Bayard F

更新日期：1985-11-27 00:00:00

abstract：:We previously showed in a primary culture of rat testicular cells that spermatogenic cells specifically bind to somatic Sertoli cells and that this interaction is needed for spermatogenic cells to differentiate in vitro. Adopting an expression cloning procedure, we here isolated a cDNA coding for a spermatogenic cell ...

journal_title：Biochemical and biophysical research communications

authors： Maeda T,Sakashita M,Ohba Y,Nakanishi Y

更新日期：1998-07-09 00:00:00

abstract：:Amidolysis catalysed by nerve growth factor (7S-NGF) and by a glandular kallikrein, unlike that catalysed by thrombin, was not inhibited by antithrombin III, either in the presence or absence of heparin. Inhibition by alpha 1-proteinase inhibitor of thrombin-, but not of 7S-NGF- or kallikrein-catalysed amidolysis was ...

journal_title：Biochemical and biophysical research communications

authors： Long WF,Williamson FB

更新日期：1983-05-31 00:00:00

abstract：:A dye displacement method was developed for determination of the affinities of compounds toward the active site of the detergent-solubilized sarcoplasmic reticulum CaATPase. Titration of the enzyme with 2',3'-O-(2,4,6-trinitrophenyl)-ADP resulted in a large absorbance difference in the visible spectrum. Subsequent add...

journal_title：Biochemical and biophysical research communications

authors： Coll RJ,Murphy AJ

更新日期：1986-07-31 00:00:00

abstract：:Exposure to silica has been associated with progressive pulmonary inflammation and fibrosis. While the fibroblasts play an important role in the pathogenesis of silicosis, the direct interaction between silica and fibroblasts is poorly understood. We observed that silica particles stimulated intracellular ROS generati...

journal_title：Biochemical and biophysical research communications

authors： Cho YJ,Seo MS,Kim JK,Lim Y,Chae G,Ha KS,Lee KH

更新日期：1999-09-07 00:00:00

abstract：:The genomes of several vertebrates contain two genes encoding proteins highly similar to threonine synthase (TS), even though the biosynthesis of l-threonine (l-Thr) is not known to occur in these animals. We report a bioinformatic analysis of the two TS-like genes, the recombinant expression of one murine TS homolog ...

journal_title：Biochemical and biophysical research communications

authors： Donini S,Percudani R,Credali A,Montanini B,Sartori A,Peracchi A

更新日期：2006-12-01 00:00:00

abstract：:Several chemokines, belonging to both the CXC and CC classes, act as positive or negative regulators of angiogenesis. We sought to investigate the role of CXCL13, B cell-attracting chemokine 1 (BCA-1), also known as B-lymphocyte chemoattractant (BLC), on endothelial cell functions. We tested the effect of CXCL13 on HU...

journal_title：Biochemical and biophysical research communications

authors： Spinetti G,Camarda G,Bernardini G,Romano Di Peppe S,Capogrossi MC,Napolitano M

更新日期：2001-11-23 00:00:00

abstract：:Treatment of human peripheral blood monocytes with oxidized (oxLDL), minimally modified low-density lipoprotein (mmLDL) or lysophosphatidylcholine (LPC) for 24h was associated with macrophage-like differentiation, as assessed by morphology/CD14 expression. Suppression of these effects by staurosporin (STS) indicated t...

journal_title：Biochemical and biophysical research communications

authors： Weber C,Erl W,Weber PC

更新日期：1995-01-17 00:00:00

abstract：:Abnormally expressed long noncoding RNAs (lncRNAs) has been recognized as one of the key source in cardiac diseases. However, the role of lncRNA in doxorubicin (DOX)-induced cardiotoxicity remains largely unknown. In previous studies, we have screened some aberrantly expressed lncRNAs from an animal model for DOX-indu...

journal_title：Biochemical and biophysical research communications

authors： Li J,Li L,Li X,Wu S

更新日期：2018-09-18 00:00:00

abstract：:The sequence of the complement factor C8 gamma chain shares a remarkable degree of similarity with that of alpha-1-microglobulin, a member of the alpha-2u-globulin superfamily. This superfamily comprises a diverse group of distantly related animal proteins possessing characteristic structural features and similar func...

journal_title：Biochemical and biophysical research communications

authors： Hunt LT,Elzanowski A,Barker WC

更新日期：1987-11-30 00:00:00

abstract：:Hyperimmunized rabbit anti-rat apolipoprotein antibodies showed reactivity to proteins in Saccharomyces cerevisiae. Antiapolipoproteins A1, B and E reacted with proteins in both a crude extract and a lipid enriched fraction. Protein reactivity was dependent on antisera dilution. Furthermore, the different antiapolipop...

journal_title：Biochemical and biophysical research communications

authors： Keesler GA,Moore S,Usher DC,Parks LW

更新日期：1991-01-31 00:00:00

abstract：:Fas-associated protein with death domain (FADD) has been implicated in T lymphocytes, but the nature of FADD-dependent mechanism in early T cell development has not been completely elucidated. In this study, using T-cell specific deletion mice, we observed that FADD deficiency in thymocytes led to increased apoptosis ...

journal_title：Biochemical and biophysical research communications

authors： Zhang XY,Yang BY,Wang JY,Mo X,Zhang J,Hua ZC

更新日期：2014-08-22 00:00:00

abstract：:Max binding protein (MNT) is a member of the Myc/Max/Mad network that plays a role in cell proliferation, differentiation and apoptosis. We previously observed that MNT was differentially expressed in hepatocellular carcinoma (HCC) and interacted with Nck1 by 2-DE. Nck family adaptor proteins function to couple tyrosi...

journal_title：Biochemical and biophysical research communications

authors： Wu J,Zhou Q,Wang Y,Zhou X,Li J

更新日期：2012-02-03 00:00:00

abstract：:The E. coli ogt O6-alkylguanine-DNA alkyltransferase has two cysteine residues positioned identically with respect to cysteines in the E. coli ada O6-alkylguanine-DNA alkyltransferase. In order to assess their function, these residues were each substituted by a glycine to generate altered forms of the ogt protein. Mut...

journal_title：Biochemical and biophysical research communications

authors： Harris LC,Potter PM,Margison GP

更新日期：1992-08-31 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Angiogenesis is reported to play a pivotal role in the occurrence, development and metastasis of HCC. The renin-angiotensin system (RAS) is involved in the regulation of angiogenesis. Here, based on the analysis of HCC datasets from Gene Expre...

journal_title：Biochemical and biophysical research communications

authors： Ye G,Qin Y,Lu X,Xu X,Xu S,Wu C,Wang X,Wang S,Pan D

更新日期：2015-03-27 00:00:00

abstract：:Histone deacetylase inhibitors (HDACIs) are promising anti-tumor agents that selectively induce cell cycle arrest, differentiation and/or apoptosis of tumor cells. Fundamentally, HDACIs are proposed to function by activating the transcription of genes, including the potent cyclin dependent kinase inhibitor p21(WAF1). ...

journal_title：Biochemical and biophysical research communications

authors： Hirsch CL,Ellis DJ,Bonham K

更新日期：2010-11-26 00:00:00

abstract：:Fourteen kb murine GLUT4 minigene (= -7395 GLUT4) contains DNA sequence that confers tissue specific, exercise-induced up-regulation of the GLUT4 gene in skeletal muscle and high-fat diet induced-down-regulation in white adipose tissue. To identify the DNA sequences required for regulated expression, we generated GLUT...

journal_title：Biochemical and biophysical research communications

authors： Tsunoda N,Cooke DW,Ikemoto S,Maruyama K,Takahashi M,Lane MD,Ezaki O

更新日期：1997-10-20 00:00:00

abstract：:CARMA3 was recently reported to be overexpressed in cancers and associated with the malignant behavior of cancer cells. However, the expression of CARMA3 and its biological roles in colon cancer have not been reported. In the present study, we analyzed the expression pattern of CARMA3 in colon cancer tissues and found...

journal_title：Biochemical and biophysical research communications

authors： Miao Z,Zhao T,Wang Z,Xu Y,Song Y,Wu J,Xu H

更新日期：2012-09-07 00:00:00

abstract：:This is the first study to demonstrate that the AT motif binding factor 1-A (ATBF1-A) is expressed in the crypts and the bases of villi of the small intestine and negatively regulates transcription of brush-border enzyme gene, aminopeptidase-N (APN). In situ hybridization visualized a limited ATBF1-A mRNA expression i...

journal_title：Biochemical and biophysical research communications

authors： Kataoka H,Joh T,Miura Y,Tamaoki T,Senoo K,Ohara H,Nomura T,Tada T,Asai K,Kato T,Itoh M

更新日期：2000-01-07 00:00:00

abstract：:VHL tumor suppressor protein contains two domains, alpha and beta. The alpha-domain is involved in the formation of a large protein complex suggested to be involved in ubiquitin-mediated protein degradation. However, the role of the beta-domain, which may recognize the target proteins for protein degradation, remains ...

journal_title：Biochemical and biophysical research communications

authors： Okuda H,Hirai S,Takaki Y,Kamada M,Baba M,Sakai N,Kishida T,Kaneko S,Yao M,Ohno S,Shuin T

更新日期：1999-09-24 00:00:00

abstract：:To study its biological functions, tumor necrosis factor precursor (proTNF) with a molecular size of 26-KDa was obtained as a recombinant protein from Escherichia coli. The recombinant proTNF was successfully accumulated in the insoluble form, corresponding to about 10-15% of total E. coli proteins. Solubilization, ge...

journal_title：Biochemical and biophysical research communications

authors： Tanabe Y,Noguchi K,Morikawa A,Mizuno D,Soma G

更新日期：1991-08-30 00:00:00

abstract：:Application of landscape theory and the dehydron hypothesis to a crystal structure of a G85R mutant superoxide dismutase (SOD1) tetrameric complex allows for the description of a prion-like hypothesis that serves to explain propagated SOD1 misfolding. We have developed two conformational-change scenarios, one local to...

journal_title：Biochemical and biophysical research communications

authors： Healy EF

更新日期：2016-09-30 00:00:00

abstract：:T box (Tbx) genes are a large family of transcription regulators that play critical roles in invertebrate and vertebrate development. Mutations in Tbx5 gene have been found to cause Holt-Oram syndrome (HOS) in humans. Partial dysfunction of TBX5 in mouse also causes HOS phenotype. Little is known about its molecular a...

journal_title：Biochemical and biophysical research communications

authors： He ML,Chen Y,Peng Y,Jin D,Du D,Wu J,Lu P,Lin MC,Kung HF

更新日期：2002-09-20 00:00:00

abstract：:A general method to obtain the variable region DNA sequence of the immunoglobulin heavy chain using anchored polymerase chain reaction is described. Based on this DNA sequence, clone-specific oligonucleotides were designed to anneal to the complementarity determining regions. These were used to identify the original B...

journal_title：Biochemical and biophysical research communications

authors： Ratech H

更新日期：1992-02-14 00:00:00

abstract：:Glucose-stimulated mobilization of large dense-core vesicles (LDCVs) to the plasma membrane is essential for sustained insulin secretion. At present, the cytoskeletal structures and molecular motors involved in vesicle trafficking in beta-cells are poorly defined. Here, we describe simultaneous imaging of enhanced gre...

journal_title：Biochemical and biophysical research communications

authors： Varadi A,Tsuboi T,Johnson-Cadwell LI,Allan VJ,Rutter GA

更新日期：2003-11-14 00:00:00

abstract：:The exposure of organ cultured pineal glands of Syrian hamsters to forskolin, an adenylate cyclase activator, caused marked increases in serotonin N-acetyltransferase activity and melatonin content in a dose-related manner (1-100 microM) when glands were collected in the second half of the dark period. However, additi...

journal_title：Biochemical and biophysical research communications

authors： Santana C,Guerrero JM,Reiter RJ,Gonzalez-Brito A,Menendez-Pelaez A

更新日期：1988-08-30 00:00:00

abstract：:To identify novel psoriasis-associated genes, we focused on several ESTs (expressed sequence tags) whose expression was predominantly increased in the affected skin in patients with psoriasis vulgaris, as assessed by microarray assay. In this paper, a full-length cDNA corresponding to one of those ESTs (AI440266) was ...

journal_title：Biochemical and biophysical research communications

authors： Matsuzaka Y,Okamoto K,Tsuji H,Mabuchi T,Ozawa A,Tamiya G,Inoko H

更新日期：2002-10-11 00:00:00

abstract：:The K-sam gene was first identified as an amplified gene in the poorly differentiated types, especially in the scirrhous type, of gastric cancers. We have recently found and reported that the carboxyl-terminal exons of K-sam are frequently deleted in the scirrhous type of gastric cancer. The deletion generates prefere...

journal_title：Biochemical and biophysical research communications

authors： Ueda T,Sasaki H,Aoyagi K,Narikiyo M,Tsubosa Y,Kuwahara Y,Sakamoto H,Mafune K,Yoshida T,Makuuchi M,Terada M

更新日期：1999-11-30 00:00:00

abstract：:A radioimmunoassay (RIA) was developed to detect the 4200 Dalton amyloid (A4) peptide or it's precursor (A4P) in human serum or cerebrospinal fluid (CSF). A synthetic peptide containing the first 28 amino acids of the 43 amino acid A4 peptide was covalently coupled to bovine thyroglobulin and a polyclonal antiserum in...

journal_title：Biochemical and biophysical research communications

authors： Pardridge WM,Vinters HV,Miller BL,Tourtellotte WW,Eisenberg JB,Yang J

更新日期：1987-05-29 00:00:00