Forskolin, an activator of adenylate cyclase activity, promotes large increases in N-acetyl transferase activity and melatonin production in the Syrian hamster pineal gland only during the late dark period.

Abstract:

:The exposure of organ cultured pineal glands of Syrian hamsters to forskolin, an adenylate cyclase activator, caused marked increases in serotonin N-acetyltransferase activity and melatonin content in a dose-related manner (1-100 microM) when glands were collected in the second half of the dark period. However, addition of forskolin to glands collected anytime during the light period or at the beginning of the dark period failed or only modestly stimulated either pineal N-acetyltransferase activity or melatonin levels. Similar results were obtained with isoproterenol. The results suggest that intrapinealocyte regulatory mechanisms may determine the nocturnal rise in the Syrian hamster pineal gland.

authors

Santana C,Guerrero JM,Reiter RJ,Gonzalez-Brito A,Menendez-Pelaez A

doi

10.1016/s0006-291x(88)81070-2

subject

Has Abstract

pub_date

1988-08-30 00:00:00

pages

209-15

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)81070-2

journal_volume

155

pub_type

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