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MNT inhibits the migration of human hepatocellular carcinoma SMMC7721 cells.

Abstract：

:Max binding protein (MNT) is a member of the Myc/Max/Mad network that plays a role in cell proliferation, differentiation and apoptosis. We previously observed that MNT was differentially expressed in hepatocellular carcinoma (HCC) and interacted with Nck1 by 2-DE. Nck family adaptor proteins function to couple tyrosine phosphorylation signals, regulate actin cytoskeletal reorganization and lead to cell motility. In order to investigate the regulatory role of MNT in HCC migration, we used transient transfection with a MNT expressing vector to overexpress MNT protein in SMMC7721 cells, and MNT siRNA to knockdown MNT expression. Rho Family Small GTPase activation assay, Western blots and transwell assay were used to determine the migration potential of cells. We found that knockdown of MNT expression might promote SMMC7721 cell migration, while the overexpressed MNT could significantly inhibit cell migration. It further emphasized the role of MNT in inhibition of cell migration that might be a promising target for HCC chemotherapy.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wu J,Zhou Q,Wang Y,Zhou X,Li J

doi

10.1016/j.bbrc.2011.12.140

subject

Has Abstract

pub_date

2012-02-03 00:00:00

pages

93-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)02362-X

journal_volume

418

pub_type

杂志文章

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