当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > FADD is essential for glucose uptake and survival of thymocytes.

FADD is essential for glucose uptake and survival of thymocytes.

Abstract：

:Fas-associated protein with death domain (FADD) has been implicated in T lymphocytes, but the nature of FADD-dependent mechanism in early T cell development has not been completely elucidated. In this study, using T-cell specific deletion mice, we observed that FADD deficiency in thymocytes led to increased apoptosis and reduced cell numbers, which may be attributed to the reduction of Glut1 expression and correspondingly decreased glucose uptake. Furthermore, an abnormal transduction of Akt signaling was discovered in FADD(-/-) thymocytes, which may be responsible for the declined Glut1 expression. Collectively, our results demonstrate the new function of FADD in glucose metabolism and survival of early T cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zhang XY,Yang BY,Wang JY,Mo X,Zhang J,Hua ZC

doi

10.1016/j.bbrc.2014.07.092

subject

Has Abstract

pub_date

2014-08-22 00:00:00

pages

202-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)01341-2

journal_volume

451

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Human neuroblastoma cell differentiation requires protein kinase C-theta.

    abstract：:Neuroblastoma LAN-5 cells exposed to retinoic acid cease to multiply and extend neurite outgrowths acquiring a neuronal phenotype. We now report that protein kinase C-theta; (PKC-theta;) isozyme is involved in this differentiation process due to the following findings: (i) PKC-theta; is expressed by LAN-5 cells as a n...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3950

    authors： Sparatore B,Patrone M,Passalacqua M,Pedrazzi M,Pontremoli S,Melloni E

    更新日期：2000-12-20 00:00:00

  • Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles.

    abstract：:We have developed a charge-mediated fusion method to reconstitute the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in giant unilamellar vesicles (GUV). Intracellular Ca2+ transport by SERCA controls key processes in human cells such as proliferation, signaling, and contraction. Small-molecule effectors of SERCA are...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.10.096

    authors： Bian T,Autry JM,Casemore D,Li J,Thomas DD,He G,Xing C

    更新日期：2016-12-09 00:00:00

  • Substrate specificity differences between recombinant rat testes endopeptidase EC 3.4.24.15 and the native brain enzyme.

    abstract：:We have characterized and compared the substrate specificity of affinity-purified recombinant rat testes endopeptidase EC 3.4.24.15 (EP 24.15) with that reported for the isolated brain enzyme. Of the peptides tested, only bradykinin, dynorphin A1-8, and neurotensin were efficiently cleaved by the recombinant enzyme (k...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1569

    authors： Lew RA,Hey NJ,Tetaz TJ,Glucksman MJ,Roberts JL,Smith AI

    更新日期：1995-04-26 00:00:00

  • A unique low frequency Raman band associated with metal binding to metallothionein.

    abstract：:We find that the low frequency Raman spectrum of Zn(II) metallothionein has a single prominent band at 138 cm-1 which is absent from the Raman spectrum of the metal-free protein. This feature is also found for Cd(II) binding to both of the independent metallothionein domains and the metallothionein from Neurospora cra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92333-4

    authors： Elgren TE,Wilcox DE

    更新日期：1989-09-15 00:00:00

  • Metabolism of the mutagen MeIQx in vivo: metabolite screening by liquid chromatography-thermospray mass spectrometry.

    abstract：:2-Amino-3,8-dimethylimidazo(4,5-f)quinoxaline (MeIQx) is a potent mutagen found in cooked food. MeIQx and its isotopically labelled (13C, 15N2 and 14C) analogues were synthesised and used for metabolic studies in vivo. An equimolar mixture of MeIQx and its 13C, 15N2 stable isotope labelled analogue (containing tracer ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80284-x

    authors： Gooderham NJ,Watson D,Rice JC,Murray S,Taylor GW,Davies DS

    更新日期：1987-11-13 00:00:00

  • A selective adenosine A2A receptor agonist, ATL-146e, prevents concanavalin A-induced acute liver injury in mice.

    abstract：BACKGROUND AND AIMS:Concanavalin A (Con A) activates T lymphocytes and induces CD4+ T cell-mediated hepatic injury in mice. Pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and interleukin-6 (IL-6), are critical mediators in this experimental model. Activation o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.185

    authors： Odashima M,Otaka M,Jin M,Horikawa Y,Matsuhashi T,Ohba R,Linden J,Watanabe S

    更新日期：2006-09-08 00:00:00

  • Crystal structure of GTPase-activating domain from human MgcRacGAP.

    abstract：:Cytokinesis in animal cells relies on a centralspindlin complex consisting of male germ cell RacGap (MgcRacGAP) and mitotic kinesin-like protein 1 (MKLP1). Rho GTPases act as molecular switches to regulate the actin cytoskeleton for cytokinesis, of which Rac1 is regulated by MgcRacGAP. In this study, we determined the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.04.094

    authors： Matsuura A,Lee HH

    更新日期：2013-06-07 00:00:00

  • Isolation and properties in culture of human adrenal capillary endothelial cells.

    abstract：:The isolation of human adrenal capillary endothelial (HACE) cells without resort to fluorescence activated cell sorting is described, together with their properties in culture. HACE cells were isolated by plating collagenase digests at high dilution in the presence of endothelial cell growth supplement, followed by cl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91503-5

    authors： Fawcett J,Harris AL,Bicknell R

    更新日期：1991-01-31 00:00:00

  • Mitochondrial localization of fission yeast manganese superoxide dismutase is required for its lysine acetylation and for cellular stress resistance and respiratory growth.

    abstract：:Manganese-dependent superoxide dismutase (MnSOD) is localized in the mitochondria and is important for oxidative stress resistance. Although transcriptional regulation of MnSOD has been relatively well studied, much less is known about the protein's posttranslational regulation. In budding yeast, MnSOD is activated af...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.01.103

    authors： Takahashi H,Suzuki T,Shirai A,Matsuyama A,Dohmae N,Yoshida M

    更新日期：2011-03-04 00:00:00

  • Phospholipase D1 decreases type I collagen levels in hepatic stellate cells via induction of autophagy.

    abstract：:Hepatic stellate cells (HSCs) are major players in liver fibrogenesis. Accumulating evidence shows that suppression of autophagy plays an important role in the development and progression of liver disease. Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.04.149

    authors： Seo HY,Jang BK,Jung YA,Lee EJ,Kim HS,Jeon JH,Kim JG,Lee IK,Kim MK,Park KG

    更新日期：2014-06-20 00:00:00

  • Fc:Fc interactions revealed by spin-labeled IgG heterosaccharides in model immune complexes.

    abstract：:Dynamic properties of spin-labelled heterosaccharides in the Fc-region of murine monoclonal antihapten immunoglobulin G were studied in model immune complexes (IC) as a function of the IC size. Model IC dimers, trimers and oligomers were formed using bivalent photoaffinity antigens. The ESR spectrum exhibits two compo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)91201-5

    authors： Kusumi A,Winkelhake JL

    更新日期：1986-05-29 00:00:00

  • 5-Fluorouracil enhances the chemosensitivity of gastric cancer to TRAIL via inhibition of the MAPK pathway.

    abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the ability to selectively trigger cancer cell apoptosis and can be used as a target for tumor therapy. However, gastric cancer cells are usually insensitive to TRAIL so reducing this drug resistance may improve the treatment of gastric cancer. In thi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2021.01.006

    authors： Li H,Lv J,Guo J,Wang S,Liu S,Ma Y,Liang Z,Wang Y,Qi W,Qiu W

    更新日期：2021-01-18 00:00:00

  • DNA and ribonucleotide binding characteristics of two forms of the androgen receptor from rat prostates.

    abstract：:Androgen receptors (sedimentation value approximately 4S and Stokes radius 2.8 nm) present in the cytoplasmic fraction obtained from prostates of castrated rats bind to DNA-Sepharose and double stranded DNA. A receptor fragment (sedimentation value approximately 3S and Stokes radius 2.3 nm) obtained from rat prostates...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90682-4

    authors： Mulder E,Vrij AA,Brinkmann AO

    更新日期：1983-08-12 00:00:00

  • Deltakephalin, Tyr-D-Thr-Gly-Phe-Leu-Thr: a new highly potent and fully specific agonist for opiate delta-receptors.

    abstract：:Deltakephalin, Tyr-D-Thr-Gly-Phe-Leu-Thr (DTLET) was rationally designed as pure delta-probe from proposed models of mu and delta opiate receptors. On peripheral organs, deltakephalin displays a 3000 times higher inhibitory potency on the electrically stimulated mouse vas deferens (IC50 = 0.15 nM) as on the guinea pig...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90318-2

    authors： Zajac JM,Gacel G,Petit F,Dodey P,Rossignol P,Roques BP

    更新日期：1983-03-16 00:00:00

  • N(6)-Methyldeoxyadenosine, a nucleoside commonly found in prokaryotes, induces C2C12 myogenic differentiation.

    abstract：:N(6)-methyl-2(')-deoxyadenosine (MedAdo) is a nucleoside naturally found in prokaryotic DNA. Interestingly, the N(6)-methylation of adenine in DNA seems to have been counter-selected during the course of evolution since MedAdo has not been detected in mammalian DNA until now. We show here that treatment with MedAdo in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.12.132

    authors： Charles MP,Ravanat JL,Adamski D,D'Orazi G,Cadet J,Favier A,Berger F,Wion D

    更新日期：2004-02-06 00:00:00

  • Evidence for proteasomal degradation of Kv1.5 channel protein.

    abstract：BACKGROUND:The voltage-gated potassium channel Kv1.5 plays a critical role in the maintenance of the membrane potential. While protein degradation is one of the major mechanisms for the regulation of channel functions, little is known on the degradation mechanism of Kv1.5. METHODS AND RESULTS:Kv1.5 was expressed in CO...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.09.053

    authors： Kato M,Ogura K,Miake J,Sasaki N,Taniguchi S,Igawa O,Yoshida A,Hoshikawa Y,Murata M,Nanba E,Kurata Y,Kawata Y,Ninomiya H,Morisaki T,Kitakaze M,Hisatome I

    更新日期：2005-11-11 00:00:00

  • The influence of Pyk2 on the mechanical properties in fibroblasts.

    abstract：:The cell surface receptor integrin is involved in signaling mechanical stresses via the focal adhesion complex (FAC) into the cell. Within FAC, the focal adhesion kinase (FAK) and Pyk2 are believed to act as important scaffolding proteins. Based on the knowledge that many signal transducing molecules are transiently i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.02.059

    authors： Klemm AH,Kienle S,Rheinlaender J,Schäffer TE,Goldmann WH

    更新日期：2010-03-19 00:00:00

  • Serine phosphorylation on position 1033 of vinculin impacts cellular mechanics.

    abstract：:This study evaluates the influence of S1033 vinculin phosphorylation on the mechanical properties of cells. We demonstrate that MEFvcl KO cells transfected with the non-phosphorylatable eGFP-vinculin mutant S1033A are of lower stiffness compared to MEFvcl Rescue and phospho-mimicking mutant S1033D cells, which were of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.06.122

    authors： Auernheimer V,Goldmann WH

    更新日期：2014-07-25 00:00:00

  • Separation of dolichol and dolichyl-P in microsomal and lysosomal compartments of hepatocytes.

    abstract：:The distribution, labeling and interrelationship of microsomal and lysosomal dolichol and dolichyl-P in rat liver was investigated. After membrane induction with phenobarbital, N-nitrosodiethylamine and diethylhexylphthalate, the amount of microsomal and lysosomal dolichols are modulated independently. Liposomal label...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(83)80022-9

    authors： Edlund C,Chojnacki T,Dallner G

    更新日期：1983-09-30 00:00:00

  • Enhancement of thrombin receptor activation by thrombin receptor-derived heptapeptide with para-fluorophenylalanine in place of phenylalanine.

    abstract：:Thrombin receptor-derived peptide SFLLRNP (one-letter amino acid code) which corresponds to the N-terminal heptapeptide of tethered ligand is able to activate thrombin receptor and to stimulate the phosphoinositide (PI) turnover. The replacement of Phe-2 by Ala eliminated this activity completely, showing the crucial ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1680

    authors： Nose T,Shimohigashi Y,Ohno M,Costa T,Shimizu N,Ogino Y

    更新日期：1993-06-15 00:00:00

  • Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages.

    abstract：:In several inflammatory conditions such as rheumatoid arthritis or sepsis, the regulatory mechanisms of inflammation are inefficient and the excessive inflammatory response leads to damage to the host. Sirtuins are class III histone deacetylases that modulate the activity of several transcription factors that are impl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.03.088

    authors： Fernandes CA,Fievez L,Neyrinck AM,Delzenne NM,Bureau F,Vanbever R

    更新日期：2012-04-20 00:00:00

  • Polypyrimidine tract-binding protein influences negative strand RNA synthesis of dengue virus.

    abstract：:Flavivirus non-structural protein 4A (NS4A) induces membrane rearrangements to form viral replication complex and functions as interferon antagonist. However, other non-structural roles of NS4A protein in relation to virus life-cycle are poorly defined. This study elucidated if dengue virus (DENV) NS4A protein interac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.05.036

    authors： Jiang L,Yao H,Duan X,Lu X,Liu Y

    更新日期：2009-07-24 00:00:00

  • Activation of simian virus 40 promoter by HTLV-I Tax protein: role of NF-kappaB and CBP.

    abstract：:HTLV-I is implicated with adult T-cell leukemia and certain other clinical disorders. The viral Tax protein is regarded as a key element in HTLV-I pathogenicity due to its ability to activate a wide variety of cellular regulatory factors. As such, Tax may likely activate also latent infection of certain other pathogen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.137

    authors： Tabakin-Fix Y,Huleihel M,Aboud M

    更新日期：2004-06-11 00:00:00

  • Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells.

    abstract：:Nutritional and pharmacological factors are needed to prevent bone loss that occurs with increasing age. The chemical compounds that act on bone metabolism as nutrients in food, however, are poorly understood. The effect of resveratrol, a natural phytoestrogen, on the proliferation and differentiation of osteoblastic ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9870

    authors： Mizutani K,Ikeda K,Kawai Y,Yamori Y

    更新日期：1998-12-30 00:00:00

  • Advanced glomerulosclerosis is reversible in nephrotic mice.

    abstract：:Advanced glomerulosclerosis, a common hallmark of chronic renal diseases (CRD) is believed to be irreversible, and it is thought that glomerular hyperfiltration and hypertrophy may participate in its pathogenesis. We demonstrate here that glomerulosclerosis is "reversible" in an animal model. We used nephrotic ICGN (n...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4903

    authors： Mizuno-Horikawa Y,Mizuno S,Tamura S,Kurosawa T

    更新日期：2001-06-15 00:00:00

  • Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway.

    abstract：:Type 2 diabetes mellitus is thought to be partially associated with endoplasmic reticulum (ER) stress toxicity on pancreatic beta cells and the result of decreased insulin synthesis and secretion. In this study, we showed that a well-known insulin sensitizer, metformin, directly protects against dysfunction and death ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.11.073

    authors： Jung TW,Lee MW,Lee YJ,Kim SM

    更新日期：2012-01-06 00:00:00

  • Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury.

    abstract：:Cellular actions of isoflavones may mediate the beneficial health effects associated with high soy consumption. We have investigated protection by genistein and daidzein against oxidative stress-induced endothelial injury. Genistein but not daidzein protected endothelial cells from damage induced by oxidative stress. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.05.197

    authors： Hernandez-Montes E,Pollard SE,Vauzour D,Jofre-Montseny L,Rota C,Rimbach G,Weinberg PD,Spencer JP

    更新日期：2006-08-04 00:00:00

  • Calcium release associated with discharge of specific granule contents from human neutrophils.

    abstract：:Neutrophil discharge of calcium into the ambient medium was measured, using an ion-sensitive electrode, after cells were stimulated with phorbol myristate acetate. Dose-dependent calcium efflux was observed over the same range of stimulus concentrations associated with specific granule marker release. Calcium efflux w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90282-3

    authors： Styrt B,Schwartz MA,Klempner MS

    更新日期：1988-08-15 00:00:00

  • Specific roles of Rac1 and Rac2 in motile functions of HT1080 fibrosarcoma cells.

    abstract：:Rho family proteins are constitutively activated in the highly invasive human fibrosarcoma HT1080 cells. We now investigated the specific roles of Rac1 and Rac2 in regulating morphology, F-actin organization, adhesion, migration, and chemotaxis of HT1080 cells. Downregulation of Rac1 using specific siRNA probes result...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.06.098

    authors： Niggli V,Schlicht D,Affentranger S

    更新日期：2009-09-04 00:00:00

  • Reduced expression of Bax in ceramide-resistant HL-60 subline.

    abstract：:Ceramide, the backbone of sphingolipids, has been reported to be involved in various cellular responses including apoptosis. We recently established and characterized a C2-ceramide-resistant HL-60 subline designated HL-CR. HL-CR cells were resistant to not only ceramide but also anti-cancer drugs including daunorubici...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.152

    authors： Sawai H,Kawai S,Domae N

    更新日期：2004-06-18 00:00:00