Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury.

abstract：:Dysregulation of microRNAs has been demonstrated to be involved in a variety of biological events related to cancer, including proliferation, metastasis, angiogenesis and immune escape. MiR-616-3p is located on the chromosome region 12q13.3, however, its potential role and clinical implications in gastric cancer remai...

journal_title：Biochemical and biophysical research communications

authors： Wu ZH,Lin C,Liu CC,Jiang WW,Huang MZ,Liu X,Guo WJ

更新日期：2018-07-02 00:00:00

abstract：:Down syndrome (DS) leads to cardiac defects which are common and significant in babies with DS. We recently generated chimeric mice carrying a human chromosome (hChr) 21. The contribution ratio of embryonic stem (ES) cells containing a hChr 21 was specifically low in the heart, compared to other organs, and cardiovasc...

journal_title：Biochemical and biophysical research communications

authors： Inoue T,Shinohara T,Takehara S,Inoue J,Kamino H,Kugoh H,Oshimura M

更新日期：2000-06-24 00:00:00

abstract：:The monoclonal antibody 6E2 raised against the embryonal carcinoma cell line NCR-G3 had been shown to also react with human germ cells. Thin-layer chromatography (TLC) immunostaining revealed that 6E2 specifically reacts with sialosylglobopenta osylceramide (sialylGb5), which carries an epitope of stage-specific embry...

journal_title：Biochemical and biophysical research communications

authors： Sato B,Katagiri YU,Miyado K,Akutsu H,Miyagawa Y,Horiuchi Y,Nakajima H,Okita H,Umezawa A,Hata J,Fujimoto J,Toshimori K,Kiyokawa N

更新日期：2007-12-28 00:00:00

abstract：:Neuropathic pain is triggered by damage to or as a result of the dysfunction of the somatosensory nervous system. Gene expression profiling using DNA microarray and real-time PCR have emerged as powerful tools for the elucidation of pain-specific pathways and identification of candidate biomarkers and therapeutic targ...

journal_title：Biochemical and biophysical research communications

authors： Wan G,Yang K,Lim Q',Zhou L,He BP,Wong HK,Too HP

更新日期：2010-10-01 00:00:00

abstract：:We demonstrate for the first time that major structural changes are imposed on various phospholipid bilayers by diacylglycerol, a product of phosphatidylinositol metabolism. By 5 mole percent in phosphatidylethanolamine a lamellar to hexagonal transition starts that is complete at 10 mole percent. At 30 mole percent i...

journal_title：Biochemical and biophysical research communications

authors： Das S,Rand RP

更新日期：1984-10-30 00:00:00

abstract：:A number of genes have been identified in the fully sequenced genome of Saccharomyces cerevisiae that appear to be conserved throughout evolution and the function of which remains poorly understood. In this manuscript we describe the initial characterization of yeast BUD31 gene. cDNA sequences highly related to BUD31 ...

journal_title：Biochemical and biophysical research communications

authors： Masciadri B,Areces LB,Carpinelli P,Foiani M,Draetta G,Fiore F

更新日期：2004-08-06 00:00:00

abstract：:To search autoantigens in autoimmune pancreatitis (AIP), we have screened the human pancreas cDNA library with a patient's serum and obtained 10 positive clones. Seven out of 10 clones were amylase alpha-2A, the autoantibody to which was specifically detected in sera from patients with AIP and fulminant type 1 diabete...

journal_title：Biochemical and biophysical research communications

authors： Takizawa S,Endo T,Wanjia X,Tanaka S,Takahashi M,Kobayashi T

更新日期：2009-08-14 00:00:00

abstract：:The newly identified drug transporter MRP is functionally linked to a multiple drug resistance independent from P-glycoprotein. Resistance modifiers for this type of MDR are rare at present. We analyzed the modulating effect of the highly selective bisindolylmaleimide PKC inhibitor GF 109203X on the MRP overexpressing...

journal_title：Biochemical and biophysical research communications

authors： Gekeler V,Boer R,Ise W,Sanders KH,Schächtele C,Beck J

更新日期：1995-01-05 00:00:00

abstract：:The effect of musk xylene on contents of both cytochrome P-450IA1 and cytochrome P-450IA2 in rat liver was investigated using Western blotting analysis. Rats were treated i.p. for five consecutive days with either 50, 100 or 200 mg musk xylene/kg body weight. Musk xylene increased both total cytochrome P-450 and cytoc...

journal_title：Biochemical and biophysical research communications

authors： Iwata N,Minegishi K,Suzuki K,Ohno Y,Kawanishi T,Takahashi A

更新日期：1992-04-15 00:00:00

abstract：:HMGB proteins are abundant, non-histone proteins in eukaryotic chromatin. HMGB proteins contain one or two conserved "HMG boxes" and can be sequence-specific or nonspecific in their DNA binding. HMGB proteins cause strong DNA bending and bind preferentially to deformed DNAs. We wish to understand how HMGB proteins inc...

journal_title：Biochemical and biophysical research communications

authors： Zimmerman J,Maher LJ 3rd

更新日期：2008-06-20 00:00:00

abstract：:In this work, we examined the functions of the female hormone "estrogen" on spermatogenesis of the Japanese eel (Anguilla japonica). Estradiol-17beta (E(2)), a natural estrogen in vertebrates, was present in the serum and its receptor was expressed in the testis during the whole process of spermatogenesis. Spermatogon...

journal_title：Biochemical and biophysical research communications

authors： Miura T,Miura C,Ohta T,Nader MR,Todo T,Yamauchi K

更新日期：1999-10-14 00:00:00

abstract：:Cancer cells usually utilize glucose as a carbon source for aerobic glycolysis, a phenomenon known as the Warburg effect. Increasing studies have shown that PVT1 (a long non-coding RNA, lncRNA) functions as critical regulator of multiple cancers. However, it remains totally unknown whether and how PVT1 regulates gluco...

journal_title：Biochemical and biophysical research communications

authors： Song J,Wu X,Liu F,Li M,Sun Y,Wang Y,Wang C,Zhu K,Jia X,Wang B,Ma X

更新日期：2017-08-19 00:00:00

abstract：:Animals and plants respond to bacterial infections and environmental stresses by inducing overlapping repertoires of defense genes. How the signals associated with infection and abiotic stresses are differentially integrated within a whole organism remains to be fully addressed. We show that the transcription of a Cae...

journal_title：Biochemical and biophysical research communications

authors： Kurz CL,Shapira M,Chen K,Baillie DL,Tan MW

更新日期：2007-11-16 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine which is highly expressed in skeletal muscle, and which stimulates muscle protein accretion in cultured skeletal muscle fibers. Using parental C2 skeletal myoblasts, no significant effects of IL-15 on skeletal muscle differentiation were observed. To test the hypothesis that IL-15 ...

journal_title：Biochemical and biophysical research communications

authors： Quinn LS,Haugk KL,Damon SE

更新日期：1997-10-09 00:00:00

abstract：:The family of peptidoglycan recognition proteins (PGRPs) is conserved from insects to mammals. Recently, Drosophila PGRP-SC1B was demonstrated to be an N-acetylmuramoyl-L-alanine amidase (NAMLAA), an enzyme that cleaves the lactylamide bond between muramic acid and the peptide chain in peptidoglycan (PGN). We now show...

journal_title：Biochemical and biophysical research communications

authors： Gelius E,Persson C,Karlsson J,Steiner H

更新日期：2003-07-11 00:00:00

abstract：:X-ray microanalysis has been used to determine elemental content in the cytoplasm of hepatocytes of hyperthyroid rats in comparison with euthyroid controls. No significant differences were found for any examined element (sodium, phosphorus, sulfur, chlorine, potassium, magnesium and calcium). In contrast to earlier re...

journal_title：Biochemical and biophysical research communications

authors： Smith NK,Lewiński A,Stabler-Morris S

更新日期：1983-08-30 00:00:00

abstract：:To examine whether protein kinase C (PKC) plays a role in mediating growth inhibitory effects of hexamethylene bisacetamide (HMBA) we compared a control H29 colon cancer cell line to a derivative, HT29-PKC7, that overexpresses high levels of PKC beta 1. We found that although HMBA markedly inhibited the growth of the ...

journal_title：Biochemical and biophysical research communications

authors： Choi PM,Weinstein IB

更新日期：1991-12-16 00:00:00

abstract：:TRPV5 is a Ca2+-selective channel that plays a key role in the reabsorption of Ca2+ ions in the kidney. Recently, a rare L530R variation (rs757494578) of TRPV5 was found to be associated with recurrent kidney stones in a founder population. However, it was unclear to what extent this variation alters the structure and...

journal_title：Biochemical and biophysical research communications

authors： Wang L,Holmes RP,Peng JB

更新日期：2017-10-21 00:00:00

abstract：:Transthyretin (TTR) is a human disease-associated amyloidogenic protein that has been implicated in senile systemic amyloidosis (SSA) and familial amyloidotic polyneuropathy (FAP). FAP typically results in severe and early-onset disease, and the only therapy established so far is liver transplantation; thus, developin...

journal_title：Biochemical and biophysical research communications

authors： Lee KW,Lee DH,Son H,Kim YS,Park JY,Roh GS,Kim HJ,Kang SS,Cho GJ,Choi WS

更新日期：2009-10-16 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels assembled from four subunits that each have a common membrane topology. The intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least conserved between subunits, and binds multiple intracellular proteins. We defined ...

journal_title：Biochemical and biophysical research communications

authors： Bajaj G,Hau AM,Hsu P,Gafken PR,Schimerlik MI,Ishmael JE

更新日期：2014-02-21 00:00:00

abstract：:Several chemokines, belonging to both the CXC and CC classes, act as positive or negative regulators of angiogenesis. We sought to investigate the role of CXCL13, B cell-attracting chemokine 1 (BCA-1), also known as B-lymphocyte chemoattractant (BLC), on endothelial cell functions. We tested the effect of CXCL13 on HU...

journal_title：Biochemical and biophysical research communications

authors： Spinetti G,Camarda G,Bernardini G,Romano Di Peppe S,Capogrossi MC,Napolitano M

更新日期：2001-11-23 00:00:00

abstract：:Prolonged or repeated agonist activation of G-protein-coupled receptors (GPCRs) initiates their desensitization and internalization, rendering them unresponsive to agonist activation. We analyzed how gangliosides and chondroitin sulfate affect B2 bradykinin (BK) receptors (B2Rs). Gangliosides and chondroitin sulfate d...

journal_title：Biochemical and biophysical research communications

authors： Shimazaki A,Nakagawa T,Mitoma J,Higashi H

更新日期：2012-03-30 00:00:00

abstract：BACKGROUND:RapaLink-1 is a third generation mammalian target of rapamycin (mTOR) inhibitor and displays superior inhibitory effect on mTOR complex 1 (mTORC1). mTOR pathway is known to block autophagy and inhibition of it can protect thrombosis-related diseases including atherosclerosis, antiphospholipid syndrome (APS) ...

journal_title：Biochemical and biophysical research communications

authors： Mu F,Jiang Y,Ao F,Wu H,You Q,Chen Z

更新日期：2020-04-30 00:00:00

abstract：:The effects of synthetic atrial natriuretic factor (ANF) were studied in superfused rat posterior pituitary gland. ANF (10(-6)M, 10(-10)M) significantly inhibited basal as well as KC1 (50 mM) or angiotensin II-stimulated immunoreactive arginine vasopressin secretion. The magnitude of inhibition was greater at 10(-6)M ...

journal_title：Biochemical and biophysical research communications

authors： Obana K,Naruse M,Inagami T,Brown AB,Naruse K,Kurimoto F,Sakurai H,Demura H,Shizume K

更新日期：1985-11-15 00:00:00

abstract：:Inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 are upregulated in many cancer cells. Several compounds targeting IAPs and inducing cell death in cancer cells have been developed. Some of these are synthesized mimicking the N-terminal tetrapeptide sequence of Smac/DIABLO, the natural endogenous I...

journal_title：Biochemical and biophysical research communications

authors： Cossu F,Mastrangelo E,Milani M,Sorrentino G,Lecis D,Delia D,Manzoni L,Seneci P,Scolastico C,Bolognesi M

更新日期：2009-01-09 00:00:00

abstract：:Plants are often exposed not only to short-term (S-) heat stress but also to diurnal long-term (L-) heat stress over several consecutive days; nevertheless, most previous studies of heat tolerance have used S-heat stress, such as 42 °C for 30-60 min, for evaluation. Yet the mechanisms underlying L-heat tolerance remai...

journal_title：Biochemical and biophysical research communications

authors： Ono M,Isono K,Sakata Y,Taji T

更新日期：2021-01-01 00:00:00

abstract：:We describe a novel technology for detecting nucleic acids: Probe Alteration Link Self-Assembly Reactions (PALSAR). PALSAR comprises DNA self-assembly of pairs of short DNA probes formed by alternate hybridization of three complementary regions in a pair of honeycomb probes (HCPs). Self-assembly occurs at designated s...

journal_title：Biochemical and biophysical research communications

authors： Usui M,Fujikawa T,Osawa M,Hakii C,Ikumi N,Nozaki T,Kitamura N,Hatta Y,Fujiwara S,Takei M

更新日期：2015-11-27 00:00:00

abstract：:A 24h pretreatment of the human hepatoma cell line HepG2 with dibutyryl cyclic AMP in the presence of theophylline induced a dose dependent decrease in low density lipoprotein binding, uptake and degradation. This effect is most likely due to a reduction of the LDL receptor number. Sterol synthesis from sodium acetate...

journal_title：Biochemical and biophysical research communications

authors： Maziere C,Maziere JC,Salmon S,Auclair M,Mora L,Moreau M,Polonovski J

更新日期：1988-10-14 00:00:00

abstract：:BRAF25 is an alternatively spliced protein of BRAF35 (see associated paper). We have mapped the BRAF25 gene to chromosome sub-band 19p13.3, a region where loss of chromosomal heterozygosity has been reported in about 50% of ovarian cancers. Because of the high incidence of genetic links of prostate cancer to breast an...

journal_title：Biochemical and biophysical research communications

authors： Wang C,McCarty IM,Balazs L,Li Y,Steiner MS

更新日期：2002-07-05 00:00:00

abstract：:Somatic mutations of the fibroblast growth factor receptor 3 (FGFR3) gene were detected by peptide nucleic acid (PNA)-mediated real-time PCR clamping. Mutation was detected in negative control containing only wild-type DNA due to a misincorporation of dNTPs to PNA binding sites when the amount of template DNA was decr...

journal_title：Biochemical and biophysical research communications

authors： Miyake M,Sugano K,Kawashima K,Ichikawa H,Hirabayashi K,Kodama T,Fujimoto H,Kakizoe T,Kanai Y,Fujimoto K,Hirao Y

更新日期：2007-11-03 00:00:00