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Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells.

Abstract：

:Nutritional and pharmacological factors are needed to prevent bone loss that occurs with increasing age. The chemical compounds that act on bone metabolism as nutrients in food, however, are poorly understood. The effect of resveratrol, a natural phytoestrogen, on the proliferation and differentiation of osteoblastic MC3T3-E1 cells was studied. Resveratrol dose-dependently increased DNA synthesis (10(-9)-10(-7) M) of MC3T3-E1 cells. In addition, resveratrol increased alkaline phosphatase (ALP) activity and prolyl hydroxylase activity of MC3T3-E1 cells (10(-6)-10(-5) M). Moreover, the antiestrogen tamoxifen eliminated the stimulation of MC3T3-E1 cells on the proliferation and ALP activity by resveratrol. On the other hand, resveratrol inhibited prostaglandin E2 production in MC3T3-E1 cells (10(-8)-10(-6) M). Our present study is the first to demonstrate that resveratrol directly stimulates cell proliferation and differentiation of osteoblasts.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mizutani K,Ikeda K,Kawai Y,Yamori Y

doi

10.1006/bbrc.1998.9870

subject

Has Abstract

pub_date

1998-12-30 00:00:00

pages

859-63

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)99870-9

journal_volume

253

pub_type

杂志文章

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