Cation-dependent prolactin activation of guanylate cyclase.

Abstract:

:Prolactin enhanced guanylate cyclase [E.C.4.6.1.2] two- to threefold in ovary, testis, mammary gland, liver and kidney. Dose response relationships revealed that maximal activation of this enzyme was at a concentration of one nanomolar and that increasing prolactin's concentration to the millimolar range caused no further increase in activity. There was an absolute cation requirement for prolactin's enhancement of guanylate cyclase. Calcium or manganese allowed prolactin to increase guanylate cyclase activity. Greater enhancement of this enzyme's activity by prolactin was observed when manganese was the co-factor. The data in this investigation suggest that guanylate cyclase may play a role in the mechanism of action of prolactin.

authors

Vesely DL

doi

10.1016/s0006-291x(84)80244-2

subject

Has Abstract

pub_date

1984-09-28 00:00:00

pages

1084-90

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)80244-2

journal_volume

123

pub_type

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