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Cyclodextrins as protein folding aids.

Abstract：

:Aggregation of proteins is a frequent occurrence during their transition from random coil to native structure. The influence of cyclodextrins in the refolding of carbonic anhydrase under aggregating conditions was studied. Cyclodextrin prevented formation of protein aggregates during renaturation of carbonic anhydrase. In addition, over 90% of active enzyme was recovered even at protein concentrations as high as 67 microM. The enhanced protein reactivation by cyclodextrins may be due to their ability to bind to hydrophobic sites in protein folding intermediate(s) followed by their subsequent removal as the protein refolds.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Karuppiah N,Sharma A

doi

10.1006/bbrc.1995.1778

subject

Has Abstract

pub_date

1995-06-06 00:00:00

pages

60-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71778-0

journal_volume

211

pub_type

杂志文章

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