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Dynamic compression of cartilage constructs engineered from expanded human articular chondrocytes.

Abstract：

:Recent works have shown that mechanical loading can alter the metabolic activity of chondrocytes cultured in 3D scaffolds. In this study we determined whether the stage of development of engineered cartilaginous constructs (expanded adult human articular chondrocytes/Polyactive foams) regulates the effect of dynamic compression on glycosaminoglycan (GAG) metabolism. Construct maturation depended on the culture time (3-14 days) and the donor (4 individuals). When dynamic compression was subsequently applied for 3 days, changes in GAG synthesized, accumulated, and released were significantly positively correlated to the GAG content of the constructs prior to loading, and resulted in stimulation of GAG formation only in the most developed tissues. Conversely, none of these changes were correlated with the expression of collagen type II mRNA, indicating that the response of chondrocytes to dynamic compression does not depend directly upon the stage of cell differentiation, but rather on the extracellular matrix surrounding the cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Démarteau O,Wendt D,Braccini A,Jakob M,Schäfer D,Heberer M,Martin I

doi

10.1016/j.bbrc.2003.09.099

subject

Has Abstract

pub_date

2003-10-17 00:00:00

pages

580-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X03018655

journal_volume

310

pub_type

杂志文章

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