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Molecular architecture of CTCFL.

Abstract：

:The CTCF-like protein, CTCFL, is a DNA-binding factor that regulates the transcriptional program of mammalian male germ cells. CTCFL consists of eleven zinc fingers flanked by polypeptides of unknown structure and function. We determined that the C-terminal fragment predominantly consists of extended and unordered content. Computational analysis predicts that the N-terminal segment is also disordered. The molecular architecture of CTCFL may then be similar to that of its paralog, the CCCTC-binding factor, CTCF. We speculate that sequence divergence in the unstructured terminal segments results in differential recruitment of cofactors, perhaps defining the functional distinction between CTCF in somatic cells and CTCFL in the male germ line.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Campbell AE,Martinez SR,Miranda JJ

doi

10.1016/j.bbrc.2010.04.146

subject

Has Abstract

pub_date

2010-06-04 00:00:00

pages

648-50

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)00841-7

journal_volume

396

pub_type

杂志文章

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