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Cisplatin and TNF-alpha downregulate transcription of Bcl-xL in murine malignant mesothelioma cells.

Abstract：

:Malignant mesothelioma (MM) is an aggressive and highly chemo-resistant tumour. In this study, we examined cisplatin-induced apoptosis in mouse models of this disease and investigated the role of constitutive and inducible expression of apoptosis related genes in this process. All of the four mouse MM cell lines examined expressed Bax, Bcl-xL, c-Myc, and caspase-3 but not Bcl-2. Cisplatin-induced apoptosis characterised by DNA fragmentation and cell death while caspase-3/7 was activated in 3 of 4 cell lines. Quantitation of basal gene expression showed significant differences but there was no correlation between single genes and cisplatin sensitivity. In the AC29 and AB1 models, both cisplatin and TNF-alpha downregulated Bcl-xL gene expression, indicating that this gene was a common transcriptional target in these cells. The findings of the present study provide insights into apoptotic mechanisms in mesothelioma cells and show similar patterns of gene expression to that reported in the human disease.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fox SA,Kusmiaty,Loh SS,Dharmarajan AM,Garlepp MJ

doi

10.1016/j.bbrc.2005.09.147

subject

Has Abstract

pub_date

2005-11-25 00:00:00

pages

983-91

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)02177-7

journal_volume

337

pub_type

杂志文章

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