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Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism.

Abstract：

:The mechanism of tumour necrosis factor-mediated cytotoxicity was investigated by using various inhibitors of arachidonic acid metabolism. Phospholipase A2 inhibitors with different modes of action interfered with the cytotoxic action of TNF, whereas phospholipase C inhibitors did not. Neither cyclooxygenase nor lipoxygenase-blockers had a significant effect on TNF action. Experiments with scavengers of toxic oxygen radicals gave ambiguous results. The data obtained suggest the involvement of phospholipase A2 and arachidonic acid in the cytotoxic mechanism of TNF, but the exact role of these molecules is, however, still to be determined.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Suffys P,Beyaert R,Van Roy F,Fiers W

doi

10.1016/0006-291x(87)90429-3

subject

Has Abstract

pub_date

1987-12-16 00:00:00

pages

735-43

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90429-3

journal_volume

149

pub_type

杂志文章

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