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Rearrangement of the p53 gene in human breast tumours.

Abstract：

:Rearrangement of the p53 gene is frequent in virus transformed cell lines and in chronic myelogenous leukemia. It is a rare event in solid tumours and has been reported only in osteosarcomas. In this study we have examined rearrangement of the p53 gene in human breast tumours. We found rearrangement in 35% of the patients (7 of 20 tumours examined). Normal tissue from these patients had an unrearranged gene, indicating that the genetic abnormality in the tumour is acquired during the natural process of tumorigenesis. No intronic rearrangement or allelic loss of the p53 gene was found in the breast tumour samples studied. Further, rearrangement of the p53 gene has been correlated with the p53 transcriptional status. Only two patients with rearranged p53 showed a high level of p53 RNA as well as protein expression. Thus, for the first time we report the rearrangement of the p53 gene in breast tumours, which may play a role in the process of tumorigenesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nayak BK,Patnaik S,Das BR

doi

10.1006/bbrc.1998.8444

subject

Has Abstract

pub_date

1998-04-17 00:00:00

pages

388-91

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)98444-3

journal_volume

245

pub_type

杂志文章

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