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Fast skeletal muscle troponin I is a co-activator of estrogen receptor-related receptor alpha.

Abstract：

:ERRalpha (estrogen receptor-related receptor alpha) is a member of the nuclear receptor superfamily. To further our understanding of the detailed molecular mechanism of transcriptional regulation by ERRalpha, we searched for ERRalpha-interacting proteins using a yeast two-hybrid system by screening a human mammary gland cDNA expression library with the ligand-binding domain (LBD) of ERRalpha as the "bait". Fast skeletal muscle troponin I (TNNI2), along with several known nuclear receptor co-activators, were isolated. We demonstrated that TNNI2 localizes to the cell nucleus and interacts with ERRalpha in co-immunoprecipitation experiments. GST pull-down assays also revealed that TNNI2 interacts directly with ERRalpha. Through luciferase reporter gene assays, TNNI2 was found to enhance the transactivity of ERRalpha. Combining mutagenesis and yeast two-hybrid assays, we mapped the ERRalpha-interacting domain on TNNI2 to a region encompassing amino acids 1-128. These findings reveal a new function for TNNI2 as a co-activator of ERRalpha.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Li Y,Chen B,Chen J,Lou G,Chen S,Zhou D

doi

10.1016/j.bbrc.2008.02.147

subject

Has Abstract

pub_date

2008-05-16 00:00:00

pages

1034-40

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00407-5

journal_volume

369

pub_type

杂志文章

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