当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster.

Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster.

Abstract：

:The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7Å resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised of a β-sheet and three α-helices forming a cone-like shape. However, known binding sites for RanGDP and FxFG containing peptides show electrostatic and steric differences compared to nuclear transport factor 2. A HEPES molecule bound in the structure suggests a new, and possibly physiologically relevant, ligand binding site.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Vognsen T,Kristensen O

doi

10.1016/j.bbrc.2012.02.140

subject

Has Abstract

pub_date

2012-03-30 00:00:00

pages

188-92

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)00399-3

journal_volume

420

pub_type

杂志文章

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