当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.

Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.

Abstract：

:Transgenic mice expressing the rhodopsin mutant Pro347Ser (Serine 6) display retinal degeneration through apoptosis that is characteristic of the disease retinitis pigmentosa. By 5 weeks after birth, these mice have lost approximately 35% of their photoreceptor cells. Retinas from these mice showed higher levels of cAMP compared to the levels in retinas of normal mice. Our studies provide evidence that elevated cAMP is common to the apoptotic process that occurs in retinitis pigmentosa. In addition, in vitro studies demonstrate no differences in the ability of the mutant and the wild-type rhodopsin to activate transducin, the rod cell G protein, to be phosphorylated by rhodopsin kinase or to bind arrestin. Mutants of rhodopsin, including Pro347Ser, are mistargeted to the rod inner segment, raising the possibility that rhodopsin triggers apoptosis through activation of signaling pathways not normally under its control.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Weiss ER,Hao Y,Dickerson CD,Osawa S,Shi W,Zhang L,Wong F

doi

10.1006/bbrc.1995.2686

subject

Has Abstract

pub_date

1995-11-22 00:00:00

pages

755-61

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X85726861

journal_volume

216

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Cloning and expression of a rat cytochrome P-450 11 beta-hydroxylase/aldosterone synthase (CYP11B2) cDNA variant.

    abstract：:A variant cytochrome P450 11 beta-hydroxylase/aldosterone synthase cDNA (CYP11B2) clone, pALDO-4, was isolated and sequenced from a rat zona glomerulosa cDNA library. This clone contains a 1521 bp open reading frame coding for a 506 amino acid residue protein which has a 30 amino acid extension peptide which is 6 resi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1792

    authors： Zhou M,Gomez-Sanchez CE

    更新日期：1993-07-15 00:00:00

  • The C-terminal tail of protein kinase D2 and protein kinase D3 regulates their intracellular distribution.

    abstract：:We generated a set of GFP-tagged chimeras between protein kinase D2 (PKD2) and protein kinase D3 (PKD3) to examine in live cells the contribution of their C-terminal region to their intracellular localization. We found that the catalytic domain of PKD2 and PKD3 can localize to the nucleus when expressed without other ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.02.013

    authors： Papazyan R,Rozengurt E,Rey O

    更新日期：2006-04-14 00:00:00

  • Replacement of all alpha-domain lysines with glutamates reduces metallothionein detoxification function.

    abstract：:Mammalian metallothioneins (MTs) possess eight highly conserved lysine residues, including three in each of two metal binding domains. We used site-directed mutagenesis to replace these intradomain lysines in Chinese hamster ovary MT2 with glutamic acid and/or glutamine. These mutant MTs were expressed in a metal sens...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2022

    authors： Cody CW,Huang PC

    更新日期：1994-07-29 00:00:00

  • Homozygosity mapping to chromosome 5p15 of a gene responsible for Hartnup disorder.

    abstract：:Hartnup disorder is an autosomal recessive phenotype involving a transporter for monoamino-monocarboxylic acids. Genetic analysis of the mouse model mapped its locus to human chromosome 11q13 (8). We report here the results of linkage analysis in two Japanese first cousin-marriage families. In the first family, the pr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4961

    authors： Nozaki J,Dakeishi M,Ohura T,Inoue K,Manabe M,Wada Y,Koizumi A

    更新日期：2001-06-08 00:00:00

  • Normal activation of p70 S6 kinase by insulin in cells overexpressing dominant negative 85kD subunit of phosphoinositide 3-kinase.

    abstract：:The role of heteromeric phosphoinositide (PI) 3-kinase activity in insulin signal transduction was studied by investigating the effects of (i) overexpression of a dominant negative mutant p85 (delta p85) that lacks the binding site for p110 (delta p85-overexpressing cells) and (ii) inhibition of PI 3-kinase activity b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1399

    authors： Hara K,Yonezawa K,Sakaue H,Kotani K,Kotani K,Kojima A,Waterfield MD,Kasuga M

    更新日期：1995-03-17 00:00:00

  • Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies.

    abstract：:Cyclooxygenase 2 (COX)-2 is induced by bacterial and viral infections and has complex, poorly understood roles in anti-pathogen immunity. Here, we use a knock-in luciferase reporter model to image Cox2 expression across a range of tissues in mice following treatment with the either the prototypical bacterial pathogen-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.07.006

    authors： Kirkby NS,Zaiss AK,Wright WR,Jiao J,Chan MV,Warner TD,Herschman HR,Mitchell JA

    更新日期：2013-08-23 00:00:00

  • Effect of herbal melanin on IL-8: a possible role of Toll-like receptor 4 (TLR4).

    abstract：:The production of IL-8 can be induced by LPS via TLR4 signaling pathway. In this study, we tested the effect of a herbal melanin (HM) extract, from black cumin seeds (Nigella sativa L.), on IL-8 production. We used HM and LPS in parallel to induce IL-8 production by THP-I, PBMCs, and TLR4-transfected HEK293 cells. Bot...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.04.035

    authors： El-Obeid A,Hassib A,Pontén F,Westermark B

    更新日期：2006-06-16 00:00:00

  • Reversibility of the Snail-induced epithelial-mesenchymal transition revealed by the Cre-loxP system.

    abstract：:The epithelial-mesenchymal transition (EMT), a key process in the tumor metastatic cascade, is characterized by the loss of cell-cell junctions and cell polarity, as well as the acquisition of migratory and invasive properties. Snail is an EMT-inducer whose expression in several different epithelial cells, e.g., Madin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.02.012

    authors： Ozawa M,Kobayashi W

    更新日期：2015-03-13 00:00:00

  • NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice.

    abstract：:The chemopreventive effect of nitric oxide-releasing aspirin (NO-ASA) against gastrointestinal tumorigenesis was evaluated in Min (APC(Min/+)) mice. NO-ASA consists of a traditional ASA that bears covalently attached to it an NO-releasing moiety. Four groups (N=10) of six-week-old female C57BL/6J APC(Min/+) and the co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.12.015

    authors： Williams JL,Kashfi K,Ouyang N,del Soldato P,Kopelovich L,Rigas B

    更新日期：2004-01-16 00:00:00

  • Mutational analysis of the CitA citrate transporter from Salmonella typhimurium: altered substrate specificity.

    abstract：:The CitA citrate transporter in Salmonella typhimurium is encoded by the citA gene and consists of 434 amino acid residues that probably include 12 membrane-spanning segments [Shimamoto. T., et al. (1991) J. Biochem. 110, 22-28]. CitA mutants with altered substrate specificities were isolated by in vitro mutagenesis u...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1381

    authors： Shimamoto T,Negishi K,Tsuda M,Tsuchiya T

    更新日期：1996-09-13 00:00:00

  • A novel insertion of a rearranged L1 element in exon 44 of the dystrophin gene: further evidence for possible bias in retroposon integration.

    abstract：:L1 elements are mammalian retrotransposons contributing to genome evolution and causing rare mutations in human. We describe a de novo insertion of an L1 element into the dystrophin gene resulting in skipping of exon 44 and causing Duchenne muscular dystrophy in a boy. The L1 element was rearranged due to the twin-pri...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.071

    authors： Musova Z,Hedvicakova P,Mohrmann M,Tesarova M,Krepelova A,Zeman J,Sedlacek Z

    更新日期：2006-08-18 00:00:00

  • Temperature dependent N-glycosylation of plasma membrane heat shock protein Hsp30p in Saccharomyces cerevisiae.

    abstract：:The HSP30 gene of the budding yeast Saccharomyces cerevisiae encodes a seven-transmembrane heat shock protein expressed in response to various types of stress including heat shock. Although Hsp30p contains a potential N-glycosylation consensus sequence (Asn(2)-Asp(3)-Thr(4)), whether it is actually N-glycosylated has ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.02.126

    authors： Kamo K,Takabatake A,Inoue Y,Izawa S

    更新日期：2012-03-30 00:00:00

  • The human involucrin gene is transcriptionally repressed through a tissue-specific silencer element recognized by Oct-2.

    abstract：:Involucrin is an important marker of epithelial differentiation which expression is upregulated just after basal cells are pushed into the suprabasal layer in stratified epithelia. Several transcription factors and regulatory elements had been described as responsible for turning on the gene. However, it is evident th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.034

    authors： Azuara-Liceaga E,Sandoval M,Corona M,Gariglio P,López-Bayghen E

    更新日期：2004-05-28 00:00:00

  • Prostaglandin E1 and prostaglandin I2 modulation of superoxide production by human neutrophils.

    abstract：:15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 rapidly and reversibly inhibit formyl-methionyl-leucyl-phenylalanine induced superoxide production by human neutrophils. In contrast, 15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 did not alter the rate or the total amount of superoxide production by human ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91754-0

    authors： Fantone JC,Kinnes DA

    更新日期：1983-06-15 00:00:00

  • Partial purification of 2,3-oxidosqualene-lanosterol cyclase from hog-liver. Evidence for a functional thiol residue.

    abstract：:2,3-Oxidosqualene-lanosterol cyclase is an intrinsic microsomal protein which can be solubilized by ionic (deoxycholate) and nonionic (emulphogene) detergents with good yields. The hog-liver microsomal cyclase was purified approximately 140-fold by chromatography on DEAE-cellulose and hydroxylapatite. The partially pu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80515-1

    authors： Duriatti A,Schuber F

    更新日期：1988-03-30 00:00:00

  • Lipopolysaccharide induction of autophagy is associated with enhanced bactericidal activity in Dictyostelium discoideum.

    abstract：:Innate immune cells respond to microbial invaders using pattern recognition receptors that detect conserved microbial patterns. Among the cellular processes stimulated downstream of pattern recognition machinery is the initiation of autophagy, which plays protective roles against intracellular microbes. We have shown ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.05.006

    authors： Pflaum K,Gerdes K,Yovo K,Callahan J,Snyder ML

    更新日期：2012-06-08 00:00:00

  • Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity.

    abstract：:Hypoxia is generally detected in central regions of solid tumors and regulates a variety of transcription factors including hypoxia-inducible factor-1 (HIF-1). HIF-1 plays a pivotal role in cellular response to low oxygen concentration, such as angiogenesis in tumor. Here, we found that a histone deacetylase (HDAC) in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02787-0

    authors： Mie Lee Y,Kim SH,Kim HS,Jin Son M,Nakajima H,Jeong Kwon H,Kim KW

    更新日期：2003-01-03 00:00:00

  • The functional unit of Na,K-ATPase is a monomeric alphabeta protomer.

    abstract：:The ouabain-resistant and ouabain-sensitive alpha-subunit cRNAs in various molar ratios were injected into Xenopus oocytes together with cRNA for the beta-subunit. The ouabain-resistant ATPase activity, as well as ouabain-resistant Rb+ uptake, of the injected oocytes increased linearly with increasing the amount of cR...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4292

    authors： Takeda K,Kawamura M

    更新日期：2001-02-09 00:00:00

  • Solubilization of the iron molybdenum cofactor of Azotobacter vinelandii nitrogenase in dimethylformamide and acetonitrile.

    abstract：:The iron molybdenum cofactor of Azotobacter vinelandii nitrogenase has been solubilized for the first time in dimethylformamide and acetonitrile. These solutions have the ability to reconstitute the inactive nitrogenase of the UW 45 mutant of A. vinelandii and exhibit an S = 3/2 EPR signal similar to that for the cofa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80053-5

    authors： Lough SM,Jacobs DL,Lyons DM,Watt GD,McDonald JW

    更新日期：1986-09-14 00:00:00

  • Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner.

    abstract：:Spinal and bulbar muscular atrophy (SBMA) is one of a group of human inherited neurodegenerative diseases caused by polyglutamine expansion. There is increasing evidence that generation of truncated proteins containing an expanded polyglutamine tract may be an important step in the pathogenesis of these disorders. We ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9624

    authors： Kobayashi Y,Miwa S,Merry DE,Kume A,Mei L,Doyu M,Sobue G

    更新日期：1998-11-09 00:00:00

  • Secretion of prostaglandins elicited by lipopolysaccharide and ethanol in cultured rat Kupffer cells.

    abstract：:Prostaglandins (PGs) released by cultured rat Kupffer cells in response to stimulation with lipopolysaccharide (LPS) or ethanol were extracted from culture media, separated by HPLC and measured by radioimmunoassay. LPS (0.5-5 micrograms/ml) enhanced, after a 3-4 hrs lag period, the production of PGE2 (7-10 fold by 24 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2519

    authors： Victorov AV,Hoek JB

    更新日期：1995-10-13 00:00:00

  • Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein.

    abstract：:The Bcl-2 oncoprotein is a potent inhibitor of apoptosis and is overexpressed in a variety of different malignancies. Bcl-2 function is regulated through heterodimerization with other members of the Bcl-2 protein family. In addition, several proteins that are not members of the Bcl-2 family can bind to Bcl-2, includin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5512

    authors： Antoku K,Maser RS,Scully WJ Jr,Delach SM,Johnson DE

    更新日期：2001-09-07 00:00:00

  • Intracellular retention and degradation of tissue-nonspecific alkaline phosphatase with a Gly317-->Asp substitution associated with lethal hypophosphatasia.

    abstract：:One point mutation which converts glycine-317 to aspartate of tissue-nonspecific alkaline phosphatase (TNSALP) was reported to be associated with lethal hypophosphatasia (Greenberg, C. R., et al. Genomics 17, 215-217, 1993). In order to define the molecular defect of TNSALP underlying the pathogenesis of hypophosphata...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8674

    authors： Fukushi M,Amizuka N,Hoshi K,Ozawa H,Kumagai H,Omura S,Misumi Y,Ikehara Y,Oda K

    更新日期：1998-05-29 00:00:00

  • Role of cytochrome b5 in catalysis by cytochrome P450 2B4.

    abstract：:Cytochrome b5 has been shown to stimulate, inhibit or have no effect on catalysis by P450 cytochromes. Its action is known to depend on the isozyme of cytochrome P450, the substrate, and experimental conditions. Cytochrome P450 2B4 (CYP 2B4) has been used in our laboratory as a model isozyme to study the role of cytoc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2005.09.022

    authors： Zhang H,Myshkin E,Waskell L

    更新日期：2005-12-09 00:00:00

  • Far upstream element-binding protein 1 is up-regulated in pancreatic cancer and modulates immune response by increasing programmed death ligand 1.

    abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death worldwide. So far, almost all treatments are almost ineffective for pancreatic cancer. Thus, there is an urgent need to develop novel therapeutics for pancreatic cancer treatment. Immune checkpoints blockade therapies, includi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.10.009

    authors： Fan P,Ma J,Jin X

    更新日期：2018-11-02 00:00:00

  • Rat copper/zinc superoxide dismutase gene: isolation, characterization, and species comparison.

    abstract：:A 13 kb rat Cu/ZnSOD genomic clone has been purified from a rat liver genomic library and completely characterized by restriction mapping, detailed sequencing and Southern blot analysis. This gene spans approximately 6 kb and contains five exons and four introns. Comparison of rat, mouse, and human Cu/ZnSOD genes reve...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90836-a

    authors： Hsu JL,Visner GA,Burr IA,Nick HS

    更新日期：1992-07-31 00:00:00

  • Adipogenic differentiation of adipose tissue derived adult stem cells in nude mouse.

    abstract：:We evaluated the use of a combination of adipose tissue derived adult stem cells (ADSCs) obtained from liposuction and injectable poly(lactic-co-glycolic acid) (PLGA) spheres for adipose tissue engineering. Adipogenesis was examined in nude mice injected subcutaneously with ADSCs (group I), PLGA spheres (group II), or...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.04.128

    authors： Choi YS,Cha SM,Lee YY,Kwon SW,Park CJ,Kim M

    更新日期：2006-06-30 00:00:00

  • Advanced glycation end products promote triple negative breast cancer cells via ERK and NF-κB pathway.

    abstract：:Advanced glycation end products (AGEs) are harmful compounds generated by nonspecific glycation of proteins and lipids. The accumulation of AGEs is associated with various diseases, including breast cancer. AGEs have been shown to promote a breast cancer cell line by enhancing proliferation, invasion and migration. In...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.11.182

    authors： Lee KJ,Yoo JW,Kim YK,Choi JH,Ha TY,Gil M

    更新日期：2018-01-15 00:00:00

  • Alpha-synuclein activates BV2 microglia dependent on its aggregation state.

    abstract：:Synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are defined by the presence of intracellular alpha-synuclein aggregates in neurons and/or oligodendrocytes. In addition, post mortem tissue analysis revealed profound changes in microglial morphology,...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.09.109

    authors： Hoffmann A,Ettle B,Bruno A,Kulinich A,Hoffmann AC,von Wittgenstein J,Winkler J,Xiang W,Schlachetzki JCM

    更新日期：2016-10-28 00:00:00

  • Inhibition by vanadyl of adenylate cyclase activation reactions in rat adrenal membranes.

    abstract：:In rat adrenal dispersed cells, both vanadyl and vanadate inhibited ACTH-stimulated steroidogenesis and the formation of cAMP, whereas these compounds did not inhibit the cAMP-dependent steroidogenesis. Then, the membrane fraction was prepared and activated by various secretagogues including ACTH, Gpp(NH)p, GTP gamma ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91706-1

    authors： Hayashi Y,Kimura T

    更新日期：1985-08-15 00:00:00