Polygonatum cyrtonema lectin, a potential antineoplastic drug targeting programmed cell death pathways.


:Polygonatum cyrtonema lectin (PCL), a mannose/sialic acid-binding plant lectin, has recently drawn a rising attention for cancer biologists because PCL bears remarkable anti-tumor activities and thus inducing programmed cell death (PCD) including apoptosis and autophagy in cancer cells. In this review, we focus on exploring the precise molecular mechanisms by which PCL induces cancer cell apoptotic death such as the caspase-dependent pathway, mitochondria-mediated ROS-p38-p53 pathway, Ras-Raf and PI3K-Akt pathways. In addition, we further elucidate that PCL induces cancer cell autophagic death via activating mitochondrial ROS-p38-p53 pathway, as well as via blocking Ras-Raf and PI3K-Akt pathways, suggesting an intricate relationship between autophagic and apoptotic death in PCL-induced cancer cells. In conclusion, these findings may provide a new perspective of Polygonatum cyrtonema lectin (PCL) as a potential anti-tumor drug targeting PCD pathways for future cancer therapeutics.


Wang SY,Yu QJ,Bao JK,Liu B




Has Abstract


2011-03-25 00:00:00














  • [3H]muscimol photolabels the gamma-aminobutyric acid receptor binding site on a peptide subunit distinct from that labeled with benzodiazepines.

    abstract::Affinity column-purified GABA-benzodiazepine receptor protein from bovine brain was photoaffinity labeled with both [3H]flunitrazepam and [3H]muscimol. Gel electrophoresis in sodium dodecyl sulfate revealed that the benzodiazepine binding site labeled with [3H]flunitrazepam was primarily associated with a major peptid...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Deng L,Ransom RW,Olsen RW

    更新日期:1986-08-14 00:00:00

  • Essential role of phosphatidylserine externalization in apoptosing cell phagocytosis by macrophages.

    abstract::In many apoptotic cells, phosphatidylserine (PS), that is normally restricted to the inner membrane layer, is externalized and subsequently recognized by phagocytes. However, it has been unclear whether PS externalization is sufficient for phagocytosis induction. In a cultured cell line undergoing Fas-mediated apoptos...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Shiratsuchi A,Osada S,Kanazawa S,Nakanishi Y

    更新日期:1998-05-19 00:00:00

  • Biophysical and biochemical characterization of Rv3405c, a tetracycline repressor protein from Mycobacterium tuberculosis.

    abstract::Mycobacterium tuberculosis, the causative agent of tuberculosis disease, is one among the deadliest pathogens in the world. Due to long treatment regimen, HIV co-infection, persistence of bacilli in latent form and development of XDR and TDR strains of Mtb, tuberculosis has posed serious concerns for managing the dise...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Gopalan A,Bhagavat R,Chandra N,Subbarao SH,Raja A,Bethunaickan R

    更新日期:2018-02-12 00:00:00

  • Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages.

    abstract::When human peripheral monocytes and rabbit peritoneal macrophages were incubated with hyaluronic acid, the media were found to contain interleukin-1 (IL-1) activity and to stimulate collagenase production by rabbit fibroblasts. A digestion of hyaluronic acid by testicular hyaluronidase decreased the IL-1 inducing acti...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hiro D,Ito A,Matsuta K,Mori Y

    更新日期:1986-10-30 00:00:00

  • Differentiation-dependent regulation of skeletal myogenesis by neuregulin-1.

    abstract::Neuregulins comprise a group of growth factor proteins that regulate the differentiation of skeletal muscle. Here, we report that neuregulins are regulators of myogenic differentiation and stimulate mitogenesis in L6 skeletal myoblasts. The mitogenic response to neuregulin-1 was differentiation-dependent and observed ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ford BD,Han B,Fischbach GD

    更新日期:2003-06-20 00:00:00

  • Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain.

    abstract::A synthetic inhibitor of calpain protects rat erythrocyte membrane-associated cytoskeletal proteins from proteolytic degradation (IC50 = 1 microM) which occurs when the cells are rendered permeable to Ca++. Leupeptin, a naturally occurring inhibitor of the enzyme, does not afford any protection at concentrations up to...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Mehdi S,Angelastro MR,Wiseman JS,Bey P

    更新日期:1988-12-30 00:00:00

  • Osthole promotes the suppressive effects of cisplatin on NRF2 expression to prevent drug-resistant cervical cancer progression.

    abstract::Cervical cancer is one of the most commonly diagnosed lethal malignancies among gynecological malignant tumors worldwide. Chemo-resistance is one of the key causal factors in cervical cancer death. Osthole (OST), a natural compound, exhibits various pharmacological activities, including anti-tumor effects. However, it...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Su J,Zhang F,Li X,Liu Z

    更新日期:2019-06-25 00:00:00

  • Engineered U7 snRNA mediates sustained splicing correction in erythroid cells from β-thalassemia/HbE patients.

    abstract::Repair of a splicing defect of β-globin pre-mRNA harboring hemoglobin E (HbE) mutation was successfully accomplished in erythroid cells from patients with β-thalassemia/HbE disorder by a synthetic splice-switching oligonucleotide (SSO). However, its application is limited by short-term effectiveness and requirement of...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Preedagasamzin S,Nualkaew T,Pongrujikorn T,Jinawath N,Kole R,Fucharoen S,Jearawiriyapaisarn N,Svasti S

    更新日期:2018-04-30 00:00:00

  • Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b.

    abstract::Sarafotoxins (SRTXs) are endothelin-like peptides extracted from snake venom. SRTXs stimulate the endothelin ETA and ETB receptors and enhance vasoconstriction, followed by left ventricular dysfunction and bronchoconstriction. SRTXs include four major isopeptides, S6a-d, with different subtype selectivities. Here, we ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Izume T,Miyauchi H,Shihoya W,Nureki O

    更新日期:2020-07-23 00:00:00

  • The kinetics and magnesium requirements for the folding of antigenomic delta ribozymes.

    abstract::Using an oligonucleotide hybridization assay to gain insight into the folding of delta ribozymes, we demonstrate a correlation between their folding and catalytic behavior. Together with recent structural information on the crystal structure of self-cleaved genomic delta ribozyme, in which the L3 loop interacts with J...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ananvoranich S,Perreault JP

    更新日期:2000-04-13 00:00:00

  • Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.

    abstract::Inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 are upregulated in many cancer cells. Several compounds targeting IAPs and inducing cell death in cancer cells have been developed. Some of these are synthesized mimicking the N-terminal tetrapeptide sequence of Smac/DIABLO, the natural endogenous I...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Cossu F,Mastrangelo E,Milani M,Sorrentino G,Lecis D,Delia D,Manzoni L,Seneci P,Scolastico C,Bolognesi M

    更新日期:2009-01-09 00:00:00

  • DJ-1 overexpression confers the multidrug resistance phenotype to SGC7901 cells by upregulating P-gp and Bcl-2.

    abstract::Gastric cancer (GC) is one of the most malignant tumors with high incidence and mortality worldwide, and the multidrug resistance (MDR) often results in chemotherapy failure in GC. DJ-1 has been well indicated to be associated with drug resistance in multiple cancers. However, the role of DJ-1 in the MDR of gastric ca...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Liu HY,Duan GL,Xu RY,Li XR,Xiao L,Zhao L,Ma ZX,Xu XW,Qiu LJ,Zhu ZM,Chen HP

    更新日期:2019-10-29 00:00:00

  • CRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity.

    abstract::CRAMP-18 (GEKLKKIGQKIKNFFQKL) is the antibacterial sequence derived from CRMAP, a member of cathelicidin-derived antimicrobial peptides. To develop the novel antibiotic peptides useful as therapeutic drugs requires strong antibiotic activity against bacterial and fungal cells without hemolytic effect. To this goal, th...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Shin SY,Kang SW,Lee DG,Eom SH,Song WK,Kim JI

    更新日期:2000-09-07 00:00:00

  • Oxidation of individual fatty acids yields different profiles of oxidation markers.

    abstract::Free radicals attack lipid molecules and initiate a chain of reactions that may trigger several diseases such as atherosclerosis and cancer. Several markers of oxidative stress have been proposed, including measurements of lipid peroxides and short-chain aldehydes levels and evaluation of conjugated diene formation. A...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Visioli F,Colombo C,Galli C

    更新日期:1998-04-17 00:00:00

  • Unique CCT repeats mediate transcription of the TWIST1 gene in mesenchymal cell lines.

    abstract::TWIST1, a basic helix-loop-helix transcription factor, plays critical roles in embryo development, cancer metastasis and mesenchymal progenitor differentiation. Little is known about transcriptional regulation of TWIST1 expression. Here we identified DNA sequences responsible for TWIST1 expression in mesenchymal linea...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ohkuma M,Funato N,Higashihori N,Murakami M,Ohyama K,Nakamura M

    更新日期:2007-01-26 00:00:00

  • Ntg2 of Saccharomyces cerevisiae repairs the oxidation products of 8-hydroxyguanine.

    abstract::In Escherichia coli, endonuclease III (endo III) repairs the oxidation products of 8-OHGua. However, the corresponding repair enzymes in eukaryotes have not been identified. Here we report that 8-hydroxyguanine (8-OHGua) is highly sensitive to further oxidation. We also show that Ntg2, a functional homolog of endo III...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kim JE,You HJ,Choi JY,Doetsch PW,Kim JS,Chung MH

    更新日期:2001-08-03 00:00:00

  • Evidence that in situ generated reactive oxygen species act as a potent stage I tumor promoter in mouse skin.

    abstract::A body of indirect evidence has suggested the involvement of reactive oxygen species (ROS) in tumor promotion. However, direct evidence for the involvement of in situ generated ROS in tumor promotion is lacking at present. This study provides the first in situ evidence for the involvement of ROS in stage I tumor promo...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Giri U,Sharma SD,Abdulla M,Athar M

    更新日期:1995-04-17 00:00:00

  • Vectors with hidden cloning sites.

    abstract::A general strategy is described for using the cleavage site of restriction enzymes in vectors for cloning regardless of how many sites the given enzymes have in the vector. The application of this method allows one to open any vector at its cloning site with protruding ends which can be compatible with almost every co...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Welker E,Váradi A

    更新日期:2000-05-10 00:00:00

  • DNA ligase IV as a new molecular target for temozolomide.

    abstract::Temozolomide (TMZ) is a methylating agent used in chemotherapy against glioblastoma. This work was designed to clarify details in repair pathways acting to remove DNA double-strand breaks (DSBs) induced by TMZ. Cultured mouse embryonic fibroblasts were used which were deficient in DSB repair genes such as homologous r...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kondo N,Takahashi A,Mori E,Ohnishi K,McKinnon PJ,Sakaki T,Nakase H,Ohnishi T

    更新日期:2009-10-02 00:00:00

  • A high-sensitive HMab-2 specifically detects IDH1-R132H, the most common IDH mutation in gliomas.

    abstract::Isocitrate dehydrogenase 1 (IDH1) mutations have been detected in gliomas and other tumors. Although IDH1 catalyzes the oxidative carboxylation of isocitrate to α-ketoglutarate (α-KG) in cytosol, mutated IDH1 proteins possess the ability to change α-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG). Several mono...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Fujii Y,Ogasawara S,Oki H,Liu X,Kaneko MK,Takano S,Kato Y

    更新日期:2015-10-30 00:00:00

  • Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration.

    abstract::Liver regeneration is controlled by multiple signaling pathways induced by a variety of growth factors, hormones, and cytokines. Here we report that protein kinase B (PKB)/Akt, part of a key cell survival signaling pathway, is markedly activated after partial hepatectomy (PHX). The antiapoptotic protein Bad, a downstr...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hong F,Nguyen VA,Shen X,Kunos G,Gao B

    更新日期:2000-12-29 00:00:00

  • Epicatechin selectively prevents nitration but not oxidation reactions of peroxynitrite.

    abstract::The flavanol (-)-epicatechin has been found to protect against damage inflicted by peroxynitrite, an inflammatory intermediate. Here, epicatechin was tested in systems of increasing complexity. The compound efficiently protected against nitration of protein tyrosine residues by peroxynitrite (IC(50) approximately 0.02...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Schroeder P,Klotz LO,Buchczyk DP,Sadik CD,Schewe T,Sies H

    更新日期:2001-07-20 00:00:00

  • Genomic organization and amplification of the human epidermal type II keratin genes K1 and K5.

    abstract::Keratins are a family of structurally related proteins that form the intermediate filament cytoskeleton in epithelial cells. Mutations in K1 and K5 result in the autosomal dominant disorders epidermolytic hyperkeratosis/bullous congenital ichthyosiform erythroderma and epidermolysis bullosa simplex, respectively. Most...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Whittock NV,Eady RA,McGrath JA

    更新日期:2000-07-21 00:00:00

  • Specific binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate on membranes of HL-60 cells.

    abstract::Membranes of HL-60 cells were shown to possess saturable binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate, with nanomolar affinity (KD = 90 nM) and a density of 250 fmol/mg protein. The specificity of the binding sites for Ins(1,3,4,5)P4 was assessed by competition studies utilising a variety of inositol polyp...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bradford PG,Irvine RF

    更新日期:1987-12-16 00:00:00

  • Inactivation of bradykinin and kallidin by cathepsin G and mast cell chymase.

    abstract::Human neutrophil cathepsin G and human skin chymase can inactivate bradykinin by cleavage at the carboxy terminal phenylalanyl-arginyl peptide bond of this polypeptide. The mast cell enzyme is far more effective than cathepsin G, the rates of hydrolysis being comparable to that found for angiotensin I to angiotensin I...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Reilly CF,Schechter NB,Travis J

    更新日期:1985-03-15 00:00:00

  • An N-terminal fragment of mouse DGAT1 binds different acyl-CoAs with varying affinity.

    abstract::A histidine-tagged recombinant N-terminal fragment of type-1 mouse liver diacylglycerol acyltransferase (DGAT; EC, MmDGAT1(1-95)His6, was expressed in Escherichia coli, and used to investigate possible acyl-CoA-binding properties. Analysis of the purified fragment by MALDI-TOF mass spectrometry revealed a po...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Siloto RM,Madhavji M,Wiehler WB,Burton TL,Boora PS,Laroche A,Weselake RJ

    更新日期:2008-08-29 00:00:00

  • Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.

    abstract::Junctional membrane complexes (JMCs) generated by junctophilins are required for Ca(2+)-mediated communication between cell-surface and intracellular channels in excitable cells. Knockout mice lacking neural junctophilins (JP-DKO) show severe motor defects and irregular cerebellar plasticity due to abolished channel c...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ikeda A,Miyazaki T,Kakizawa S,Okuno Y,Tsuchiya S,Myomoto A,Saito SY,Yamamoto T,Yamazaki T,Iino M,Tsujimoto G,Watanabe M,Takeshima H

    更新日期:2007-11-23 00:00:00

  • BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line.

    abstract::Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases but its etiology is unclear. Alpha-synuclein (alpha-SN) is a major component of Lewy bodies and Lewy neurites, and its missense mutations, A30P and A53T, cause familial PD. In PD, alpha-SN-positive glial inclusions are distributed mainly ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kohno R,Sawada H,Kawamoto Y,Uemura K,Shibasaki H,Shimohama S

    更新日期:2004-05-21 00:00:00

  • Delivery of anti-GAP-43 antibodies into neuroblastoma cells reduces growth cone size.

    abstract::We have previously demonstrated that antibodies to the growth-associated protein, GAP-43, introduced intracellularly using a lipid carrier inhibited neurite outgrowth in NB2a/d1 neuroblastoma cells, and that culturing of these cells on adhesive substrates such as laminin or poly-L-lysine overcame this restriction. The...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Shea TB

    更新日期:1994-08-30 00:00:00

  • Transport characteristics of 5-aminosalicylic acid into colonic epithelium: Involvement of sodium-coupled monocarboxylate transporter SMCT1-mediated transport system.

    abstract::5-Aminosalicylic acid (5-ASA) is conventionally used as a first line drug for inflammatory bowel disease (IBD). Because 5-ASA is well absorbed in the small intestine, very high dose of 5-ASA is required to deliver it to the large intestine which is a target site. Interestingly, 5-ASA is reported to be transported into...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yuri T,Kono Y,Fujita T

    更新日期:2020-04-09 00:00:00