MAP kinase phosphatase MKP-1 regulates p-ERK1/2 signaling pathway with fluoride treatment.

abstract：:To investigate the effect of ionophores on Cl- distribution in human erythrocyte suspensions, we measured the membrane potential by using 19F and 31P NMR methods. Incubation of human erythrocytes with 0.005 mM of the neutral ionophores valinomycin and nonactin resulted in membrane potentials of -21.2 and -17.8 mV in t...

journal_title：Biochemical and biophysical research communications

authors： Wittenkeller L,Mota de Freitas D,Ramasamy R

更新日期：1992-04-30 00:00:00

abstract：:A substantial body of data indicates that reactive oxygen intermediates (ROIs) are implicated in pathogenesis of diverse human diseases. Oxidative stress induced by ROIs often causes cell death via apoptosis that is regulated by a plenty of functional genes and their protein products. Bcl-2 is one such protein that bl...

journal_title：Biochemical and biophysical research communications

authors： Jang JH,Surh YJ

更新日期：2004-07-30 00:00:00

abstract：:The characterization of a 20 kilodalton (20 kD) variant of rat growth hormone is reported. The 20 kD variant from rat pituitary gland extracts was identified on Western immunoblots of polyacrylamide gels. It was also shown that pituitary tissue maintained in culture secretes the 20 kD form. A rat growth hormone cDNA f...

journal_title：Biochemical and biophysical research communications

authors： Howland DS,Farrington MA,Taylor WD,Hymer WC

更新日期：1987-09-15 00:00:00

abstract：:Endothelin, a vasoconstrictor peptide, plays important roles not only in the mammalian circulatory system but also in non-mammalian systems, such as the gill lamellar vascular network with complex structural characteristics. Here, we show that (i) the contraction of pillar cells that delimit the lamellar vasculature i...

journal_title：Biochemical and biophysical research communications

authors： Sultana N,Nag K,Kato A,Hirose S

更新日期：2007-03-30 00:00:00

abstract：:Helicobacter pylori is a pathogenic flagellated bacterium that infects the gastroduodenal mucosa and causes peptic ulcers in humans. FliD caps the distal end of the flagellar filament and is essential in filament growth. Moreover, FliD has been studied to diagnose and prevent H. pylori infection. Here, we report struc...

journal_title：Biochemical and biophysical research communications

authors： Cho SY,Song WS,Oh HB,Kim HU,Jung HS,Yoon SI

更新日期：2019-06-18 00:00:00

abstract：:Photoacoustic Fourier-transform infrared spectroscopy was used to study phosphoamino acids and phosphoproteins. Using this method, we have found that the spectral properties of phosphate esters depend on the nature of the linkage, pH, and binding of metal ion. At high pH values, dianionic symmetric stretching of phosp...

journal_title：Biochemical and biophysical research communications

authors： Graves DJ,Luo S

更新日期：1994-11-30 00:00:00

abstract：:To date, little is known about the molecular mechanisms controlling the regulation of phospholipase C-delta1 (PLC-delta1) gene expression. To understand the mechanisms responsible for the regulation of PLC-delta1 gene expression, the 5'-flanking region of the mouse PLC-delta1 gene was isolated from a mouse genomic DNA...

journal_title：Biochemical and biophysical research communications

authors： Kim JK,Lee WK,Nam HW,Lee KH,Han H,Rha HK,Jun TY,Kim KS,Choi CR

更新日期：2000-06-24 00:00:00

abstract：:Platelets play essential roles in hemostasis and thrombosis by aggregating with each other. However, the molecular mechanism governing platelet aggregation is not yet fully understood. Here, we established an assay system using platelets permeabilized with streptolysin-O to analyze mechanism of the thrombin-induced ag...

journal_title：Biochemical and biophysical research communications

authors： Nishioka H,Horiuchi H,Tabuchi A,Yoshioka A,Shirakawa R,Kita T

更新日期：2001-02-02 00:00:00

abstract：:We measured the amounts of total A beta, A beta 1-40 and A beta 1-42/43 in brain tissues using a newly developed ELISA assay and found that the amounts of insoluble A beta 1-42/43 and insoluble A beta 1-40 were linearly related to the amount of A beta deposits or total insoluble A beta at their lower and higher concen...

journal_title：Biochemical and biophysical research communications

authors： Tamaoka A,Kondo T,Odaka A,Sahara N,Sawamura N,Ozawa K,Suzuki N,Shoji S,Mori H

更新日期：1994-11-30 00:00:00

abstract：:Large tumor suppressor kinase 1 (LATS1) is a serine/threonine kinase of the AGC kinase family in mammals and involved in various biological processes, it is a key regulator of cell cycle progression. However, the role of LATS1 in central nervous system trauma is still unknown. In present study, we performed an acute s...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Chen M

更新日期：2018-10-20 00:00:00

abstract：:Nek2 is a mammalian protein kinase that is structurally homologous to NIMA, a mitotic regulator in Aspergillus nidulans. To understand the possible cellular processes in which Nek2 participates during the cell cycle, we investigated the expression and subcellular localization of Nek2 in mitotic cells. The Nek2 protein...

journal_title：Biochemical and biophysical research communications

authors： Ha Kim Y,Yeol Choi J,Jeong Y,Wolgemuth DJ,Rhee K

更新日期：2002-01-18 00:00:00

abstract：:We have determined the identity of the orphan G-protein coupled receptor cDNA, 6H1, present in activated chicken T cells, as a subtype of P2Y purinoceptor. This identification is based on first on the degree of sequence identity shared with recently cloned members of the P2Y receptor family and second on the pharmacol...

journal_title：Biochemical and biophysical research communications

authors： Webb TE,Kaplan MG,Barnard EA

更新日期：1996-02-06 00:00:00

abstract：:We investigated mechanisms of cytotoxicity induced by doxycycline (doxy) and minocycline (mino) in the chronic myeloid leukemia K562 cell line. Doxy and mino induced cell death in exposure-dependent manner. While annexin V/propidium iodide staining was consistent with apoptosis, the morphological changes in Giemsa sta...

journal_title：Biochemical and biophysical research communications

authors： Fares M,Abedi-Valugerdi M,Hassan M,Potácová Z

更新日期：2015-07-31 00:00:00

abstract：:Tight junctions (TJs) restrict paracellular flux of water and solutes in epithelia and endothelia. In epidermis, the physiological role of TJs is not fully understood. In this study, sodium caprate (C10), which dilates intestinal TJs, was applied to cultured human epidermal keratinocytes and reconstructed human epider...

journal_title：Biochemical and biophysical research communications

authors： Kurasawa M,Kuroda S,Kida N,Murata M,Oba A,Yamamoto T,Sasaki H

更新日期：2009-04-03 00:00:00

abstract：:The calcium-sensing receptor (CaR) is a G protein-coupled receptor that plays key roles in extracellular calcium ion (Ca(2+)(o)) homeostasis by enabling parathyroid, kidney, and other cells to directly "sense" changes in Ca(2+)(o). In multiple myeloma-associated bone disease, myeloma cells could raise the level of Ca(...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi T,Yamauchi M,Sugimoto T,Chauhan D,Anderson KC,Brown EM,Chihara K

更新日期：2002-12-13 00:00:00

abstract：:We have recently reported that mutant but not wild-type (wt) p53 protein was ADP-ribosylated in primary rat cells overexpressing the temperature-sensitive murine p53val135 gene. To examine whether the lack of susceptibility to modification is a specific feature of p53val135 adopting wt conformation or rather a general...

journal_title：Biochemical and biophysical research communications

authors： Wesierska-Gadek J,Schmid G,Cerni C

更新日期：1996-07-05 00:00:00

abstract：:Depending on culture in either "low Ca++" (0.25 mM) or "normal Ca++" (1.8 mM) medium, human colon adenocarcinoma-derived CaCo-2 cells exhibit differential sensitivity to the antiproliferative action of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and of two side-chain modified analogs, 1,25S,26-trihydroxy-delta 22-vitamin D...

journal_title：Biochemical and biophysical research communications

authors： Cross HS,Huber C,Peterlik M

更新日期：1991-08-30 00:00:00

abstract：:The c-myc oncogene is implicated in normal growth and differentiation processes. Human cell lines IM9 and HepG2 stably cultured at "low" glucose concentrations (5.5 mM) show c-myc mRNA levels 3-4 times higher than cells cultured at "high" glucose concentrations (25 nM). D-fructose (a metabolizable exose) substitutes f...

journal_title：Biochemical and biophysical research communications

authors： Briata P,Laurino C,Gherzi R

更新日期：1989-12-29 00:00:00

abstract：:The x-ray absorption near edge structure (XANES) spectra of hemoglobin and myoglobin have been measured at the wiggler beam line of the Frascati Synchrotron Radiation Facility. The energy shifts of the iron absorption jump edge and the chemical shifts of the bound excited state at threshold of 1s core excitations, goi...

journal_title：Biochemical and biophysical research communications

authors： Bianconi A,Congiu-Castellano A,Dell'Ariccia M,Giovannelli A,Burattini E,Durham PJ

更新日期：1985-08-30 00:00:00

abstract：:In fresh water planarian Dugesia japonica, two genes encoding POU-domain proteins, DjPOU1 and DjPOU2, have been identified by polymerase chain reaction (PCR). Their POU-domains are strikingly similar to class III POU-domains in mammals, frog, insects and nematode. The full-length cDNA of DjPOU1 has been cloned and seq...

journal_title：Biochemical and biophysical research communications

authors： Orii H,Agata K,Watanabe K

更新日期：1993-05-14 00:00:00

abstract：:We have designed and constructed a plasmid (pE7RZ-1) that contains a gene for a hammerhead ribozyme that specifically cleaves cottontail rabbit papillomavirus (CRPV) E7 RNA sequences in vitro. The in vitro produced transcripts of pE7RZ-1 cleave CRPV E7 target sequences in trans at 37 degrees C. Pretreatment of pE7RZ-1...

journal_title：Biochemical and biophysical research communications

authors： Wisotzkey JD,Krizenoskas A,DiAngelo S,Kreider JW

更新日期：1993-04-30 00:00:00

abstract：:Glucocorticoid-suppressible hyperaldosteronism (GSH) is one variety of primary aldosteronism with hypertension and is inherited in an autosomal dominant mode. A recent report has indicated that GSH is caused by a gene duplication arising from unequal crossing over between the two genes, CYP11B1 and CYP11B2, encoding P...

journal_title：Biochemical and biophysical research communications

authors： Miyahara K,Kawamoto T,Mitsuuchi Y,Toda K,Imura H,Gordon RD,Shizuta Y

更新日期：1992-12-15 00:00:00

abstract：:In this study, acetosyringone was identified as one of the major extracellular phenolics in tobacco suspension cells and was shown to have bioactive properties that influence early events in plant-bacterial pathogenesis. In our model system, tobacco cell suspensions treated with bacterial isolate Pseudomonas syringae ...

journal_title：Biochemical and biophysical research communications

authors： Baker CJ,Mock NM,Whitaker BD,Roberts DP,Rice CP,Deahl KL,Aver'yanov AA

更新日期：2005-03-04 00:00:00

abstract：:Insulin-stimulated GLUT4 recruitment to the plasma membrane is impaired in insulin resistance. We recently reported that a cell permeable phosphoinositide-binding peptide induces GLUT4 recruitment as potently as insulin, but does not activate GLUT4 to initiate glucose uptake. Here we investigated whether the peptide-i...

journal_title：Biochemical and biophysical research communications

authors： Funaki M,Benincasa K,Randhawa PK

更新日期：2007-09-07 00:00:00

abstract：:Casein kinase II (CKII) activity in colorectal tumours was compared before and after heterotransplantation onto nude mice. The test revealed that the enzyme activity was about two-fold enhanced in the tumours isolated from the nude mice when compared to the respective primary tumours from which they were derived. Immu...

journal_title：Biochemical and biophysical research communications

authors： Seitz G,Münstermann U,Schneider HR,Issinger OG

更新日期：1989-08-30 00:00:00

abstract：:The present study provides the first evidence that nitropolycyclic aromatic hydrocarbons such as 1-nitropyrene and 2-nitrofluorene are metabolized to the corresponding formylamino compounds in animal bodies. The study shows that the formation of such novel metabolites, 1-formylaminopyrene and 2-formylaminofluorene, is...

journal_title：Biochemical and biophysical research communications

authors： Tatsumi K,Amano H

更新日期：1987-01-30 00:00:00

abstract：:Ultraviolet, fluorescence and CD spectral analysis suggested unusual structural features of Rhodotorula gracilis ATCC 90950 DNA. R. gracilis DNA exhibited 13% hyperchromicity at 260 nm as against 26% shown by calf thymus DNA. The biphasic melting curve, one phase between 88-92 degrees C and the other between 92-97 deg...

journal_title：Biochemical and biophysical research communications

authors： Vishnuvardhan D,Divakar S,Joseph R

更新日期：1995-06-26 00:00:00

abstract：:The arylamide 2-acetylaminofluorene (AAF) is a powerful carcinogen displaying a marked promoting activity, also known to regulate expression of liver detoxifying proteins. In this study we identified CYP3A23, a major inducible cytochrome P-450 (CYP) isoform, as an AAF target in hepatocytes. Indeed, exposure to AAF of ...

journal_title：Biochemical and biophysical research communications

authors： Sparfel L,Payen L,Gilot D,Sidaway J,Morel F,Guillouzo A,Fardel O

更新日期：2003-01-10 00:00:00

abstract：:FKBP59-HBI, a heat shock protein hsp90-binding immunophilin that was originally detected in heterooligomer forms of steroid receptors, is retained on Calmodulin (CAM)-Sepharose 4B in the presence of 2 mM Ca2+ and is eluted by EGTA, demonstrating a specific p59-CAM interaction. The p59 amino acid sequence reveals the p...

journal_title：Biochemical and biophysical research communications

authors： Massol N,Lebeau MC,Renoir JM,Faber LE,Baulieu EE

更新日期：1992-09-30 00:00:00

abstract：:Lysinuric protein intolerance (LPI; MIM 222700) is an autosomal recessive disorder characterized by defective transport of cationic amino acids lysine, arginine and ornithine. The defect is localized in the basolateral membrane of polar epithelial cells of the renal tubules and intestine. The SLC7A7 (solute carrier fa...

journal_title：Biochemical and biophysical research communications

authors： Toivonen M,Mykkänen J,Aula P,Simell O,Savontaus ML,Huoponen K

更新日期：2002-03-15 00:00:00