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Identification of 6H1 as a P2Y purinoceptor: P2Y5.

Abstract：

:We have determined the identity of the orphan G-protein coupled receptor cDNA, 6H1, present in activated chicken T cells, as a subtype of P2Y purinoceptor. This identification is based on first on the degree of sequence identity shared with recently cloned members of the P2Y receptor family and second on the pharmacological profile. Upon transient expression in COS-7 cells the 6H1 receptor bound the radiolabel [35S]dATP alpha S specifically and with high affinity (Kd, 10 nM). This specific binding could be competitively displaced by a range of ligands active at P2 purinoceptors, with ATP being the most active (K (i)), 116 nM). Such competition studies have established the following rank order of activity: ATP ADP 2-methylthioATP alpha, beta-methylene ATP, UTP, thus confirming 6H1 as a member of the growing family of P2Y purinoceptors. As the fifth receptor of this type to be identified we suggest that it be named P2Y5.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Webb TE,Kaplan MG,Barnard EA

doi

10.1006/bbrc.1996.0189

subject

Has Abstract

pub_date

1996-02-06 00:00:00

pages

105-10

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)90189-8

journal_volume

219

pub_type

杂志文章

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