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Acetic acid activates PKD1L3-PKD2L1 channel--a candidate sour taste receptor.

Abstract：

:The polycystic kidney disease (PKD) 1L3-PKD2L1 channel is a candidate sour taste receptor expressed in mammalian taste receptor cells. Various acids are reported to activate PKD channels after the removal of the acid stimuli, but little information is available on the activation of these channels by acetic acid. It was difficult to analyze the PKD channel activation by acetic acid using Ca2+ imaging experiments because this acid induces a transient and nonspecific response in cultured cells. Here, we developed a novel method to evaluate PKD channel activation by acetic acid. Nonspecific responses were observed only over a short period after the application of acetic acid. In contrast, PKD channel activation evoked by acetic acid as well as citric acid was detected even at a later time point. This method revealed that PKD1L3-PKD2L1 channel activation by acetic acid was pH-dependent and occurred when the ambient pH was <3.1.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ishii S,Misaka T,Kishi M,Kaga T,Ishimaru Y,Abe K

doi

10.1016/j.bbrc.2009.05.069

subject

Has Abstract

pub_date

2009-07-31 00:00:00

pages

346-50

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01003-1

journal_volume

385

pub_type

杂志文章

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