In vivo transfer efficiency of antisense oligonucleotides into the myocardium using HVJ-liposome method.

abstract：:Heart fatty acid binding protein (H-FABP) is a 15kDa protein that mediates the passage of fatty acids from the plasma membrane to sites of lipid synthesis. We report here, for the first time, that H-FABP is a potent inducer of cardiac myocyte hypertrophy, stimulating an increase in cell surface area, protein synthesis...

journal_title：Biochemical and biophysical research communications

authors： Burton PB,Hogben CE,Joannou CL,Clark AG,Hsuan JJ,Totty NF,Sorensen C,Evans RW,Tynan MJ

更新日期：1994-12-30 00:00:00

abstract：:The stabilized carbonium ion salt, tropylium tetrafluoroborate, was oxidized to tropone (cycloheptatrienone) by rabbit liver aldehyde oxidase but not by the closely related molybdenum hydroxylase, xanthine oxidase. The tropylium cation is an aromatic hydrocarbon which lacks the aldehyde, imine, or iminium functional g...

journal_title：Biochemical and biophysical research communications

authors： Banks RB,Barnett SD

更新日期：1986-10-30 00:00:00

abstract：:To clarify the role of hepatocyte growth factor (HGF) in embryonic lung development, organoids from fetal rat lung were cultured in collagen gels with or without HGF antisense oligonucleotides. Cyst-like structures formed within 24 h in organoids isolated from fetuses after 14 days' gestation, but this was abolished b...

journal_title：Biochemical and biophysical research communications

authors： Itakura A,Kurauchi O,Morikawa S,Okamura M,Furugori K,Mizutani S

更新日期：1997-12-08 00:00:00

abstract：:Activation of muscarinic cholinergic receptors on 1321N1 human astrocytoma cells leads to Ca2+ mobilization as measured by quin 2 fluorescence. Acetylcholine and methacholine were full and potent agonists, while carbachol and muscarine, were fully efficacious but 6- and 10-fold less potent than acetylcholine. The carb...

journal_title：Biochemical and biophysical research communications

authors： Noronha-Blob L,Richard C,U'Prichard DC

更新日期：1987-08-31 00:00:00

abstract：:C-type natriuretic peptide (CNP) which potently stimulates particulate guanylate cyclase activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA synthesis of the cells 10-fold more effectively than alpha-human atrial natriuretic peptide (alpha-hANP). The inhibitory effect of CNP was mi...

journal_title：Biochemical and biophysical research communications

authors： Furuya M,Yoshida M,Hayashi Y,Ohnuma N,Minamino N,Kangawa K,Matsuo H

更新日期：1991-06-28 00:00:00

abstract：:Expression of the cytochrome P-450 monooxygenase activity 7-ethoxyresorufin O-deethylase (7-ERD) was surveyed in proliferating and quiescent cultures of murine cell line C-10, a non-tumorigenic line of presumed alveolar type II origin. 7-ERD activities were undetectable in subconfluent/proliferating cultures but becam...

journal_title：Biochemical and biophysical research communications

authors： Reiners JJ Jr,Pavone A,Cantu AR,Auerbach C,Malkinson AM

更新日期：1992-02-28 00:00:00

abstract：:Tooth development is a highly organized process characterized by reciprocal interactions between epithelium and mesenchyme. However, the expression patterns and functions of molecules involved in mouse tooth development are unclear from the viewpoint of explaining human dental malformations and anomalies. Here, we sho...

journal_title：Biochemical and biophysical research communications

authors： Miyado M,Ogi H,Yamada G,Kitoh J,Jogahara T,Oda S,Sato I,Miyado K,Sunohara M

更新日期：2007-11-16 00:00:00

abstract：:Proximal spinal muscular atrophy (SMA) results from loss of the survival motor neuron 1 (SMN1) gene, with retention of its nearly identical homolog, SMN2. There is a direct correlation between disease severity and SMN2 copy number. Mice do not have a Smn2 gene, and thus cannot naturally replicate the disorder. However...

journal_title：Biochemical and biophysical research communications

authors： Gogliotti RG,Hammond SM,Lutz C,Didonato CJ

更新日期：2010-01-01 00:00:00

abstract：:Previous studies have suggested that nitric oxide (NO) which is synthetized by nitric oxide synthase (NOS) is closely related to the carcinogenesis and progression of colon cancer. However, the precise physiopathological role of NO on colon cancer remains unclear, and a lot of related studies focused on NOS2 and NOS3,...

journal_title：Biochemical and biophysical research communications

authors： Wang Q,Ye S,Chen X,Xu P,Li K,Zeng S,Huang M,Gao W,Chen J,Zhang Q,Zhong Z,Liu Q

更新日期：2019-08-06 00:00:00

abstract：:Expression of TNF-alpha gene in the retinal pigment epithelial (RPE) cells was studied by using polymerase chain reaction (PCR). PCR for human TNF-alpha gene using complementary DNA (cDNA) of control RNA prepared from non-stimulated RPE cells failed to show expression of TNF-alpha gene. However, PCR by using cDNA prep...

journal_title：Biochemical and biophysical research communications

authors： Tanihara H,Yoshida M,Yoshimura N

更新日期：1992-09-16 00:00:00

abstract：:In epithelial cells progression through the G1 phase of the cell cycle and preparing the cell for the S phase is regulated by cyclin D1-cdk4. Cells that express the retinoblastoma protein (pRb) are dependent on cyclin D1-cdk4 activity for their proliferation while cells that do not express pRb are not. Overexpression ...

journal_title：Biochemical and biophysical research communications

authors： Kent LL,Hull-Campbell NE,Lau T,Wu JC,Thompson SA,Nori M

更新日期：1999-07-14 00:00:00

abstract：:The biological function of hnRNP family proteins is widely diverse and involved in pre-mRNA processing, transcriptional regulation, recombination, and telomere maintenance. In the course of our study on the elucidation of biological functions of minisatellite DNA, we isolated several nuclear proteins that bind to the ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka E,Fukuda H,Nakashima K,Tsuchiya N,Seimiya H,Nakagama H

更新日期：2007-06-29 00:00:00

abstract：:Cells have developed compensatory mechanisms to restore cell volume, and the ability to resist osmotic swelling or shrinkage parallels their resistance to necrosis or apoptosis. There are several mechanisms by which cells adapt to hyposmotic stress including that of regulatory volume decrease. In ischemia and reperfus...

journal_title：Biochemical and biophysical research communications

authors： Díaz-Elizondo J,Chiong M,Rojas-Rivera D,Olea-Azar C,Kwon HM,Lavandero S

更新日期：2006-12-01 00:00:00

abstract：:Using red cells as an experimental model, we previously showed that a limited degradation of certain membrane proteins by calpain (Ca2+-activated thiol protease) was a necessary prerequisite for cell fusion and that fusibility depended on the ratio of calpain to its endogenous inhibitor calpastatin. Here we show that ...

journal_title：Biochemical and biophysical research communications

authors： Barnoy S,Glasner T,Kosower NS

更新日期：1996-03-27 00:00:00

abstract：:PKCdelta was revealed to make a homologous protein complex that shows a high protein kinase activity upon H(2)O(2) stimulation by expressing the enzymes having different epitope tags in COS-7 cells. The association of the endogenous PKCdelta in the cells was observed by sucrose density gradients. Analysis using the mu...

journal_title：Biochemical and biophysical research communications

authors： Umada-Kajimoto S,Yamamoto T,Matsuzaki H,Kikkawa U

更新日期：2006-03-03 00:00:00

abstract：:A photoaffinity label, 4-azidobenzoyltrimethionine has been synthesized. It competitively inhibits trimethionine uptake in the yeast C. albicans. Upon UV irradiation it irreversibly and specifically blocks oligopeptide uptake. These results give the first example of photoinhibition of peptide uptake in yeast. ...

journal_title：Biochemical and biophysical research communications

authors： Sarthou P,Gonneau M,Le Goffic F

更新日期：1983-02-10 00:00:00

abstract：:Previous reports have shown that CaM-kinase IV can phosphorylate the transcription factor CREB in vitro on Ser133. Furthermore, transfected CaM-kinase IV can activate CREB-dependent transcription, but at a lower efficiency than the cAMP-kinase. In this paper we examine the kinetics and site-specificity of CREB phospho...

journal_title：Biochemical and biophysical research communications

authors： Enslen H,Tokumitsu H,Soderling TR

更新日期：1995-02-27 00:00:00

abstract：:A novel aa3-type cytochrome oxidase from the extremely halophilic archaeon, Halobacterium halobium, differs significantly from those of other prokaryotic and eukaryotic cytochrome oxidases (Fujiwara, T., Fukumori, Y., and Yamanaka, T. (1989) J. Biochem. 105, 287-292). In the present study, we cloned and sequenced the ...

journal_title：Biochemical and biophysical research communications

authors： Denda K,Fujiwara T,Seki M,Yoshida M,Fukumori Y,Yamanaka T

更新日期：1991-11-27 00:00:00

abstract：:A voltage-dependent K+ current has been revealed in whole-cell recordings carried out on immortalized cells obtained from the human tracheal epithelium. At positive membrane potentials the current shows a time dependent inactivation which is accelerated by increasing the depolarizing step. Forskolin, a direct activato...

journal_title：Biochemical and biophysical research communications

authors： Galietta LJ,Rasola A,Barone V,Gruenert DC,Romeo G

更新日期：1991-09-30 00:00:00

abstract：:The corticotropin releasing factor (CRF) plays a central role in regulating the activities of hypothalamic-pituitary-adrenal (HPA) axis in the presence of a variety of stressful stimuli via binding to its type 1 receptors (CRFR1). Despite that many peptidic or non-peptidic antagonists of CRFR1 have been developed to s...

journal_title：Biochemical and biophysical research communications

authors： Yu J,Zhuo R,Peng P,Liu X,Yan H,Zhang S,Zheng J,Wei X,Ma X

更新日期：2015-07-31 00:00:00

abstract：:Centaurin-alpha(1) was originally described as a binding partner for phosphoinositides. In spite of the presence of a putative ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) domain, no ARF-GAP activity has been attributed to centaurin-alpha(1) so far. Thus the function of this protein remains to be dete...

journal_title：Biochemical and biophysical research communications

authors： Dubois T,Zemlickova E,Howell S,Aitken A

更新日期：2003-02-07 00:00:00

abstract：:CD45 is a leukocyte-specific, two domain transmembrane tyrosine phosphatase. Co-purification of a recombinant protein containing the first phosphatase domain of CD45 (6His-D1) with a recombinant protein containing the second phosphatase domain (GST-D2) from E. coli indicated a stable interaction which resulted in incr...

journal_title：Biochemical and biophysical research communications

authors： Felberg J,Johnson P

更新日期：2000-05-10 00:00:00

abstract：:Hematopoiesis is a complex process tightly controlled by sets of transcription factors in a context-dependent and stage-specific manner. Smad2/3 transcription factor plays a central role in differentiation and survival of erythroid cells. Here we report that follistatin-like 1 (FSTL1) treatment impairs hemin-induced e...

journal_title：Biochemical and biophysical research communications

authors： Wu J,Dong Y,Teng X,Cheng M,Shen Z,Chen W

更新日期：2015-10-30 00:00:00

abstract：:Vascular pericytes and smooth muscle cells surround many blood vessels of the body. Their primary roles include vessel stabilization and regulation of the blood flow. The high degree of heterogeneity among these cells is dictated by (1) differences in their developmental origin and (2) their location in the vascular b...

journal_title：Biochemical and biophysical research communications

authors： Halaidych OV,Mummery CL,Orlova VV

更新日期：2019-05-21 00:00:00

abstract：:Parathyroid hormone (PTH) enhances cystic fibrosis transmembrane conductance regulator (CFTR)-mediated anion secretion by the human intestinal epithelial cell line Caco-2. With the patch-clamp and Ussing chamber techniques, we investigated how PTH stimulates CFTR activity in Caco-2 cells. Cell-attached recordings reve...

journal_title：Biochemical and biophysical research communications

authors： Jantarajit W,Wongdee K,Lertsuwan K,Teerapornpuntakit J,Aeimlapa R,Thongbunchoo J,Harvey BSJ,Sheppard DN,Charoenphandhu N

更新日期：2020-03-12 00:00:00

abstract：:In a previous genome-wide association study on milk production traits in Chinese Holstein population, we revealed VPS28 gene was highly expressed in mammary gland tissue and a -58C > T mutation in 5'-UTR of it was significantly associated with milk fat content traits. In this study, we explored the effect of this -58C...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Zhang Q

更新日期：2019-03-19 00:00:00

abstract：:Previous studies suggested that the hydrophobic protein chargerin II, which is encoded in the A6L of mitochondrial DNA, may have a key role in the energy transduction by mitochondrial H(+)-ATP synthase because an antibody against chargerin II inhibited ATP synthesis and ATP-Pi exchange, in an energy-dependent fashion....

journal_title：Biochemical and biophysical research communications

authors： Muraguchi M,Yoshihara Y,Tunemitu T,Tani I,Higuti T

更新日期：1990-04-16 00:00:00

abstract：:We showed previously that the neuropeptide, galanin, transiently and promptly increases the cytoplasmic concentration of Ca2+, [Ca2+]i, in insulin producing clonal RINm5F cells prior to a reduction in [Ca2+]i. We found that galanin (100 nM) transiently increased the [Ca2+]i in the presence of 15 mM glyceraldehyde and ...

journal_title：Biochemical and biophysical research communications

authors： Ahrén B

更新日期：1996-04-05 00:00:00

abstract：:Leukotriene B(4) (LTB(4)) is a potent chemoattractant and activator of neutrophils, macrophages and T cells. These cells are a key component of inflammation and all express BLT1, a high affinity G-protein-coupled receptor for LTB(4). However, little is known about the neuroimmune functions of BLT1. In this study, we d...

journal_title：Biochemical and biophysical research communications

authors： Kihara Y,Yokomizo T,Kunita A,Morishita Y,Fukayama M,Ishii S,Shimizu T

更新日期：2010-04-09 00:00:00

abstract：:Neonatal hypoxia can induce the persisting brain dysfunctions and subsequently result in the behavioral abnormalities in adulthood. Improving mitochondrial functions were suggested as the effective strategy for brain functional recovery. In this study, we tested the effects of physical exercise, a well-established way...

journal_title：Biochemical and biophysical research communications

authors： Sun L,Ye R,Liang R,Xing F

更新日期：2020-03-05 00:00:00