C-type natriuretic peptide is a growth inhibitor of rat vascular smooth muscle cells.

abstract：:The role of osteoblasts in inducing the proliferation and differentiation of bone marrow cells was examined. Conditioned medium obtained from mouse osteoblastic cell (MC3T3-E1) cultures stimulated colony formation of mouse bone marrow cells (CSF) and differentiation of mouse myeloid leukemia cells (M1) into macrophage...

journal_title：Biochemical and biophysical research communications

authors： Shiina-Ishimi Y,Abe E,Tanaka H,Suda T

更新日期：1986-01-14 00:00:00

abstract：:Thyrotropin receptor (TSHR) in extrathyroidal tissue, especially fat tissue, is supposed to have important roles in the development of extrathyroidal manifestations of Graves' disease. However, the molecular mechanism of TSHR expression is not known. Expression of TSHR mRNA and TSH-dependent cAMP production were obser...

journal_title：Biochemical and biophysical research communications

authors： Haraguchi K,Shimura H,Lin L,Saito T,Endo T,Onaya T

更新日期：1996-06-05 00:00:00

abstract：:Separation of proteins by two-dimensional electrophoresis and following mass spectrometry (MS) is now a conventional technique for proteomic analysis. For proteomic analysis of a certain tissue with a limited information of primary structures of proteins, we have developed an analytical system for peptide mass fingerp...

journal_title：Biochemical and biophysical research communications

authors： Hozumi A,Satouh Y,Ishibe D,Kaizu M,Konno A,Ushimaru Y,Toda T,Inaba K

更新日期：2004-07-09 00:00:00

abstract：:Previous studies have suggested that 1,25(OH)2D3, the active form of vitamin D3, may increase the survival of bone-forming osteoblasts through an inhibition of apoptosis. On the other hand, vitamin D3 has also been shown to trigger apoptosis in human cancer cells, including osteosarcoma-derived cell lines. In the pres...

journal_title：Biochemical and biophysical research communications

authors： Witasp E,Gustafsson AC,Cotgreave I,Lind M,Fadeel B

更新日期：2005-05-13 00:00:00

abstract：:In order to characterize the direct involvement of cAMP in the change of osteoblast proliferation by parathyroid hormone (PTH), we employed the diastereoisomers of adenosine 3',5'-cyclic phosphorothioate, Sp-cAMPS and Rp-cAMPS, which have been recently shown to act directly as agonist and antagonist, respectively in t...

journal_title：Biochemical and biophysical research communications

authors： Kano J,Sugimoto T,Fukase M,Fujita T

更新日期：1991-05-31 00:00:00

abstract：:To understand the molecular mechanisms involved in preleukemia, the suppression subtractive hybridization method was used in a murine radiation-induced thymic lymphoma model. Seventeen mRNAs overexpressed in preleukemic thymuses were identified: mouse laminin binding protein (p40/37LBP), E25 protein, Rattus norvegicus...

journal_title：Biochemical and biophysical research communications

authors： Verlaet M,Deregowski V,Denis G,Humblet C,Stalmans MT,Bours V,Castronovo V,Boniver J,Defresne MP

更新日期：2001-04-27 00:00:00

abstract：:Calmodulin (CaM) was reported to interact with PreIQ and IQ of CaV1.2 channels, but to date, no explicit binding sites of CaM were illustrated. Therefore, in the present study, we firstly used MOE (Molecular Operating Environment) for protein-protein docking and we found that the most likely residues of CaM that play ...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Yan S,Chen S,Zhang J,Shen Y,Su J,He G,Feng R,Shao D,Hao L

更新日期：2020-05-21 00:00:00

abstract：:Nerve Growth Factor is a 118 amino acid polypeptide that plays an important role in the differentiation and survival of neurons. The recent discovery that a mRNA that encodes beta Nerve Growth Factor is present in brain suggests that the Nerve Growth Factor gene may not only regulate gene expression of peripheral but ...

journal_title：Biochemical and biophysical research communications

authors： Rennert PD,Heinrich G

更新日期：1986-07-31 00:00:00

abstract：:Epidermal growth factor receptor (EGF-R) is a widely expressed ligand-dependent tyrosine kinase. The tyrosine residue at 845 in EGF-R corresponds to Y416 of v/c-src kinase, which is highly conserved and functionally important in many tyrosine kinases. To clarify the functional role of Y845, we constructed a mutant hum...

journal_title：Biochemical and biophysical research communications

authors： Gotoh N,Tojo A,Hino M,Yazaki Y,Shibuya M

更新日期：1992-07-31 00:00:00

abstract：:Glycated insulin was evaluated in plasma and biological tissues of diabetic animal models by immunocytochemistry (ICC) and a novel radioimmunoassay. Glycated insulin circulated at 0.10 +/- 0.04 ng/ml and 2.20 +/- 0.14 ng/ml in lean and diabetic obese (ob/ob) mice, corresponding to 12.5 and 9.8% total plasma insulin, r...

journal_title：Biochemical and biophysical research communications

authors： McKillop AM,Mooney MH,Harriott P,Flatt PR,O'Harte FP

更新日期：2001-08-24 00:00:00

abstract：:The insulin receptor gene is induced 8 to 10-fold during adipocyte differentiation. Plasmids containing the promoter, exon 1 and a portion of the first intron from either the mouse or human gene are able to modulate the expression of an insulin receptor/CAT gene 3 to 7-fold during differentiation. We have shown that s...

journal_title：Biochemical and biophysical research communications

authors： McKeon C,Accili D,Chen H,Pham T,Walker GE

更新日期：1997-11-26 00:00:00

abstract：:Anchoring protein alphaKAP targets calmodulin kinase II (CaMKII) to the sarcoplasmic reticulum (SR), and in the rabbit is a substrate of CaMKII itself in fast-twitch, but not in slow-twitch muscle. This work was aimed at elucidating the molecular basis for differential phosphorylation of alphaKAP. Here we show that tw...

journal_title：Biochemical and biophysical research communications

authors： Damiani E,Sacchetto R,Salviati L,Margreth A

更新日期：2003-02-28 00:00:00

abstract：:Glutathione (GSH) is the most abundant non-protein thiol that buffers reactive oxygen species in the brain. GSH does not reduce nitroxides directly, but in the presence of ascorbates, addition of GSH increases ascorbate-induced reduction of nitroxides. In this study, we used electron paramagnetic resonance (EPR) imagi...

journal_title：Biochemical and biophysical research communications

authors： Emoto MC,Matsuoka Y,Yamada KI,Sato-Akaba H,Fujii HG

更新日期：2017-04-15 00:00:00

abstract：:Glycogen synthase kinase (GSK)-3β interaction protein (GSKIP), a key regulator of signaling transduction, is implicated in multiple pathological processes. However, whether GSKIP is involved in myocardial infarction is unknown. The present study was designed to determine the potential involvement of GSKIP in myocardia...

journal_title：Biochemical and biophysical research communications

authors： Yan L,Cheng G,Yang G

更新日期：2020-10-29 00:00:00

abstract：:The heterodimeric F-actin capping protein cap32/34 from Dictyostelium discoideum is a typical member of a widely distributed family of cytoskeletal proteins. To analyze its regulation and structure/function relationships we cloned and expressed the subunits separately in Escherichia coli using the ATG-expression vecto...

journal_title：Biochemical and biophysical research communications

authors： Haus U,Hartmann H,Trommler P,Noegel AA,Schleicher M

更新日期：1991-12-16 00:00:00

abstract：:O-GlcNAcylation is a dynamic and reversible post-translational modification of cytonuclear molecules that regulates cellular signaling. Elevated O-GlcNAcylation is a general property of cancer and plays a critical role in cancer progression. We previously showed that the expression of FOXM1, a critical oncogenic trans...

journal_title：Biochemical and biophysical research communications

authors： Ueda Y,Moriwaki K,Takeuchi T,Higuchi K,Asahi M

更新日期：2020-01-15 00:00:00

abstract：:Alterations of the mitochondrial DNA, encoding important parts of the cellular energy-generating system (oxidative phosphorylation, OXPHOS), are often associated with the occurrence of degenerative neuromuscular diseases. Especially point mutations in the mitochondrial tRNA genes, which cannot be complemented by the n...

journal_title：Biochemical and biophysical research communications

authors： Seibel P,Flierl A,Kottlors M,Reichmann H

更新日期：1994-04-29 00:00:00

abstract：:PILRα is an immune inhibitory receptor possessing an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain enabling it to deliver inhibitory signals. Binding of PILRα to its ligand CD99 is involved in immune regulation; however, whether there are other PILRα ligands in addition to CD99 is not...

journal_title：Biochemical and biophysical research communications

authors： Kogure A,Shiratori I,Wang J,Lanier LL,Arase H

更新日期：2011-02-18 00:00:00

abstract：:Treatment with double-stranded RNA (dsRNA) has been shown to interfere with the function of specific genes in various invertebrate species. However, it has not yet been reported that this technique can be applied to vertebrates as well. We have investigated whether dsRNA treatment will inhibit gene function in zebrafi...

journal_title：Biochemical and biophysical research communications

authors： Wargelius A,Ellingsen S,Fjose A

更新日期：1999-09-16 00:00:00

abstract：:A novel protein methyltransferase has been recently described that catalyzes the esterification of the C-terminal leucine residue of the catalytic subunit of protein phosphatase 2A in a variety of eucaryotic cells. This reaction can potentially modulate the phosphatase's activity, subunit interactions, or interactions...

journal_title：Biochemical and biophysical research communications

authors： Xie H,Clarke S

更新日期：1994-09-30 00:00:00

abstract：:Cholesterol homeostasis is strictly maintained to prevent abnormal biological processes that arise from excessive accumulation of cholesterol in tissues. Although dyslipidemia causes reproductive dysfunction and endocrine disruption in male rats, regulatory factors and mechanisms have not been clearly demonstrated. Th...

journal_title：Biochemical and biophysical research communications

authors： Lim W,Bae H,Sohn JY,Jeong W,Kim SH,Song G

更新日期：2015-01-02 00:00:00

abstract：:In the TT cell line of human medullary thyroid carcinoma, the viral Harvey ras (v-rasH) oncogene induces differentiation, marked by morphological changes, diminution of growth, and increased expression of the calcitonin gene. Here, we show that the transcriptional factor c-jun is increased during v-rasH induced differ...

journal_title：Biochemical and biophysical research communications

authors： Nelkin BD,Borges M,Mabry M,Baylin SB

更新日期：1990-07-16 00:00:00

abstract：:Three principally different sites of action have been reported for proinsulin C-peptide, at surface-mediated, intracellular, and extracellular locations. Following up on the latter, we now find that (i) mass spectrometric analyses reveal the presence of the C-peptide monomer in apparent equilibrium with a low-yield se...

journal_title：Biochemical and biophysical research communications

authors： Jörnvall H,Lindahl E,Astorga-Wells J,Lind J,Holmlund A,Melles E,Alvelius G,Nerelius C,Mäler L,Johansson J

更新日期：2010-01-15 00:00:00

abstract：:Moderate alcohol consumption has been shown to reduce atherosclerosis-associated diseases. As shown in our earlier works, ethanol has a dose-dependent protective effects against endothelial cellular senescence by activating aldehyde dehydrogenase 2 (ALDH2) in vitro. However, whether ethanol administration possesses an...

journal_title：Biochemical and biophysical research communications

authors： Xue L,Zhu W,Yang F,Dai S,Han Z,Xu F,Guo P,Chen Y

更新日期：2019-04-30 00:00:00

abstract：:Diabetic cardiomyopathy is an essential complication of diabetes and characterized by persistent diastolic dysfunction, leading to myocardial fibrosis. Oxidative stress and inflammation lead to cell damage and are implicated in many disease states. In our study, we evaluated the effects of toll-like receptor 6 (TLR6) ...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Zhang Y

更新日期：2016-04-29 00:00:00

abstract：:[3H] Nitrendipine binding was partially blocked by the presence of tetrodotoxin in developing spinal cord neurons. In young cultures, 1 micron tetrodotoxin displaced 29% and 26% of [3H] nitrendipine binding from the high and low affinity binding sites, respectively. In one month old cultures, tetrodotoxin had no effec...

journal_title：Biochemical and biophysical research communications

authors： Litzinger MJ,Brenneman DE

更新日期：1984-11-14 00:00:00

abstract：:Vaspin, an adipocytokine recently identified in a rat model of type 2 diabetes, has been suggested to have an insulin-sensitizing effect. However, the exact mechanism underlying this action has not been fully elucidated. Furthermore, the specific function of vaspin is largely unknown, especially in vascular cells. We ...

journal_title：Biochemical and biophysical research communications

authors： Jung CH,Lee WJ,Hwang JY,Seol SM,Kim YM,Lee YL,Park JY

更新日期：2011-09-23 00:00:00

abstract：:PQBP-1 was identified as a binding protein to the polyglutamine tract present in various transcription-related factors and causative genes for neurodegenerative disorders. This novel gene contains at least two functional domains, WW domain and carboxyl-terminal domain (CTD), strictly conserved beyond species. Although...

journal_title：Biochemical and biophysical research communications

authors： Waragai M,Junn E,Kajikawa M,Takeuchi S,Kanazawa I,Shibata M,Mouradian MM,Okazawa H

更新日期：2000-07-05 00:00:00

abstract：:The cDNA encoding human ferrochelatase [EC 4.99.1.1] was isolated from a human placenta cDNA library in bacteriophage lambda gt11 by screening with a radiolabeled fragment of mouse ferrochelatase cDNA. The cDNA had an open reading frame of 1269 base pairs (bp) encoding a protein of 423 amino acid residues (Mr. 47,833)...

journal_title：Biochemical and biophysical research communications

authors： Nakahashi Y,Taketani S,Okuda M,Inoue K,Tokunaga R

更新日期：1990-12-14 00:00:00

abstract：:C1 inhibitor (C1IN) is a multi-facet serine protease inhibitor in the plasma cascades, inhibiting several proteases, notably, regulates both complement and contact system activation. Despite huge advancements in the understanding of C1IN based on biochemical properties and its roles in the plasma cascades, the phyloge...

journal_title：Biochemical and biophysical research communications

authors： Kumar A,Bhandari A,Sarde SJ,Goswami C

更新日期：2014-07-18 00:00:00