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C-type natriuretic peptide is a growth inhibitor of rat vascular smooth muscle cells.

Abstract：

:C-type natriuretic peptide (CNP) which potently stimulates particulate guanylate cyclase activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA synthesis of the cells 10-fold more effectively than alpha-human atrial natriuretic peptide (alpha-hANP). The inhibitory effect of CNP was mimicked by 8-bromo-cGMP. The proliferation of VSMC was also suppressed by CNP more potently than alpha-hANP, while the peptide was less active for cGMP augmentation and for vasorelaxation than alpha-hANP in isolated rat aorta. These results suggest that CNP may be a growth regulating factor of VSMC rather than a vasodilator.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Furuya M,Yoshida M,Hayashi Y,Ohnuma N,Minamino N,Kangawa K,Matsuo H

doi

10.1016/0006-291x(91)90627-j

subject

Has Abstract

pub_date

1991-06-28 00:00:00

pages

927-31

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)90627-J

journal_volume

177

pub_type

杂志文章

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