C-type natriuretic peptide is a growth inhibitor of rat vascular smooth muscle cells.

abstract：:The CXC chemokines keratinocyte-derived chemokine (KC, CXCL1) and macrophage inflammatory protein-2 (MIP-2, CXCL2) activate G-protein coupled receptor CXCR2 and are believed to have similar inflammatory effects in mice. Their specific signaling mechanisms remain elusive. A wide variety of cellular events, mediators an...

journal_title：Biochemical and biophysical research communications

authors： Lei X,Hossain M,Qadri SM,Liu L

更新日期：2012-07-06 00:00:00

abstract：:Eph receptor tyrosine kinases (RTKs) and their ephrin ligands play multiple roles in the developing nervous system, including cell segregation, axon guidance and synaptic plasticity. Here we report the expression and function of EphA7 in Xenopus hindbrain development. EphA7 is specifically expressed in the hindbrain t...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Sun J,Li C,Mao B

更新日期：2016-10-28 00:00:00

abstract：:CD44 is a major cell-surface receptor for hyaluronate (HA). By alternative RNA-splicing a large number of CD44 variants are generated. To explore the role of CD44 splicing in the regulation of cell binding to HA, three different isoforms of CD44 were transfected in the CD44 negative B-cell lymphoma line Namalwa and in...

journal_title：Biochemical and biophysical research communications

authors： van der Voort R,Manten-Horst E,Smit L,Ostermann E,van den Berg F,Pals ST

更新日期：1995-09-05 00:00:00

abstract：:Exosomes, the natural vehicles of various biological molecules, have been examined in several research fields including drug delivery. Although understanding of the biological functions of exosomes has increased, how exosomes are transported between cells remains unclear. We hypothesized that cell tropism is important...

journal_title：Biochemical and biophysical research communications

authors： Toda Y,Takata K,Nakagawa Y,Kawakami H,Fujioka S,Kobayashi K,Hattori Y,Kitamura Y,Akaji K,Ashihara E

更新日期：2015-01-16 00:00:00

abstract：:Mizoribine (MIZ) is a novel imidazole nucleoside with immunosuppressive activity. MIZ has been approved in Japan and combination therapy with MIZ and glucocorticoids has been used after renal transplantation and for lupus nephritis and rheumatoid arthritis. In this study, we identify 14-3-3 proteins as MIZ-binding pro...

journal_title：Biochemical and biophysical research communications

authors： Takahashi S,Wakui H,Gustafsson JA,Zilliacus J,Itoh H

更新日期：2000-07-21 00:00:00

abstract：:Large tonsillar lymphocytes labeled with [3H]thymidine reverted to small lymphocytes with concomitant loss of [3H]DNA upon culturing. The decrease of labeled DNA content and size of large lymphocytes was demonstrated by flow cytometry and cell sorting. These observations suggest that stimulated lymphocytes may revert ...

journal_title：Biochemical and biophysical research communications

authors： Sasvari-Szekely M,Staub M,Taljanidisz J,Szabo G Jr,Takacs J,Antoni F

更新日期：1984-12-28 00:00:00

abstract：:Brefeldin A (BFA), an endoplasmic reticulum (ER)-Golgi transport inhibitor, has been shown to cause accumulation of proteins in the ER, ER stress, and ultimately apoptosis. In this paper, we demonstrate that the knockdown of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm), a mitochondrial NADPH-generat...

journal_title：Biochemical and biophysical research communications

authors： Moon JL,Kim SY,Shin SW,Park JW

更新日期：2012-01-13 00:00:00

abstract：:The acidic leucine-rich nuclear phosphoprotein 32B (ANP32B) is a member of a conserved superfamily of nuclear proteins whose functions are largely unknown. In our previous work, ANP32B was identified as a novel direct substrate for caspase-3 and acted as a negative regulator for leukemic cell apoptosis. In this work, ...

journal_title：Biochemical and biophysical research communications

authors： Yu Y,Shen SM,Zhang FF,Wu ZX,Han B,Wang LS

更新日期：2012-07-13 00:00:00

abstract：:Anions of cytosine and thymine predominate in radiation-damaged DNA. This is in contrast to the experimental order of adiabatic electron affinities: A, 0.95; G, 1.51; >T, 0.79, U, 0.80; C, 0.56 (+/-0.05 eV). Excited negative-ion states of adenine (A) and guanine (G) are identified using semiempirical AM1-MCCI quantum ...

journal_title：Biochemical and biophysical research communications

authors： Chen ES,Chen EC

更新日期：2001-11-30 00:00:00

abstract：:Four conserved residues of Clostridium thermocellum endoglucanase CelC were replaced by site-directed mutagenesis. Proteins mutated in His-90, Asn-139 and Glu-140 showed strongly reduced activity, in agreement with predictions of sequence alignments. Mutations in Glu-140 did not result in any detectable change in Km, ...

journal_title：Biochemical and biophysical research communications

authors： Navas J,Béguin P

更新日期：1992-12-15 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT), a key process in the tumor metastatic cascade, is characterized by the loss of cell-cell junctions and cell polarity, as well as the acquisition of migratory and invasive properties. Snail is an EMT-inducer whose expression in several different epithelial cells, e.g., Madin...

journal_title：Biochemical and biophysical research communications

authors： Ozawa M,Kobayashi W

更新日期：2015-03-13 00:00:00

abstract：:T-type Ca(2+) channels are important regulators of peripheral sensory neuron excitability. Accordingly, T-type Ca(2+) currents are often increased in various pathological pain conditions, such as inflammation or nerve injury. Here we investigated effects of inflammation on functional expression of T-type Ca(2+) channe...

journal_title：Biochemical and biophysical research communications

authors： Huang D,Liang C,Zhang F,Men H,Du X,Gamper N,Zhang H

更新日期：2016-04-29 00:00:00

abstract：:We have cloned two cDNA isoforms as well as genomic sequences of the mouse Prx V gene and characterized their molecular genetic features. Two isoforms of the mouse Prx V cDNA were identified from liver and testis. The testis-originated long transcripts had extra 1164-bp 5'-UTR sequences compared to the liver-originate...

journal_title：Biochemical and biophysical research communications

authors： Lee TH,Kim SJ,Kang SW,Lee KK,Rhee SG,Yu DY

更新日期：2000-04-13 00:00:00

abstract：:Two novel alpha-neurotoxins, Oh-6A and Oh-6B, isolated from the king cobra (Ophiophagus hannah) venom, consist of 70 amino acid residues with 10 cysteine residues and share the same amino acid sequences as determined by Edman degradation on the peptide fragments generated from the proteolytic hydrolysates. Their seque...

journal_title：Biochemical and biophysical research communications

authors： Lin SR,Chang LS,Chang CC

更新日期：1999-01-08 00:00:00

abstract：:In a radioassay for Vasoactive Intestinal Peptide (VIP)-binding, eight out of 33 plasma samples from healthy human subjects exhibited specific binding ranging from 2.6% to 46.7% of total [125 I]VIP. This binding was competitively displaced by unlabeled VIP. The structurally homologous peptides, Peptide Histidine Isole...

journal_title：Biochemical and biophysical research communications

authors： Paul S,Heinz-Erian P,Said SI

更新日期：1985-07-16 00:00:00

abstract：:Rat liver ornithine decarboxylase induction by dexamethasone or laparatomy, which is dramatically impaired by catecholamine depletion, is not affected by alpha-and beta -adrenergic blockers administered simultaneously 1 h prior to steroid injection or operation. However, if blockade is maintained for 24 h, an effect c...

journal_title：Biochemical and biophysical research communications

authors： Astancolle S,Davalli P,Corti A

更新日期：1991-01-31 00:00:00

abstract：:Using a cDNA glass microarray, the expression of 1081 genes in immature and mature dendritic cells (DCs) of two different individuals has been studied. The upregulation of mRNA transcripts of genes encoding the transcription factor ZFM1, Mos proto-oncogene serine/threonine-protein kinase, B-cell-specific transcription...

journal_title：Biochemical and biophysical research communications

authors： Lapteva N,Nieda M,Ando Y,Ide K,Hatta-Ohashi Y,Dymshits G,Ishikawa Y,Juji T,Tokunaga K

更新日期：2001-07-27 00:00:00

abstract：:Pretreatment of brain synaptic membrane homogenates with Triton X-100 resulted in a drastic disclosure of [3H] glutamate (Glu) binding activity which was sensitive to one of the central Glu receptor agonists, N-methyl-D-aspartic acid (NMDA). The NMDA-sensitive binding was inversely dependent on the incubation temperat...

journal_title：Biochemical and biophysical research communications

authors： Ogita K,Yoneda Y

更新日期：1988-06-16 00:00:00

abstract：:Peptide B represents one of the most highly conserved sequences in proenkephalin. To investigate the potential presence of this peptide in the mammalian nervous system, an antiserum raised to this peptide was used to measure the distribution and molecular weight forms of immunoreactive Peptide B in the rat brain. Pept...

journal_title：Biochemical and biophysical research communications

authors： Lindberg I,White L

更新日期：1986-09-30 00:00:00

abstract：:An XWnt8-Fz5 fusion protein synergizes with LRP6 to potently activate beta-catenin-dependent signaling. Here, we generated a fusion in which XWnt8 was fused to the N-terminus of LRP6 and show it synergizes with both Fz4 and Fz5 to potently transactivate beta-catenin-dependent Wnt signaling. Based on this, we hypothesi...

journal_title：Biochemical and biophysical research communications

authors： Holmen SL,Robertson SA,Zylstra CR,Williams BO

更新日期：2005-03-11 00:00:00

abstract：:A major component of amyloid deposits found in Alzheimer disease and Down syndrome is the beta/A4 peptide, which is derived from the Alzheimer amyloid protein precursor (APP). Recent evidence indicates that increases in APP expression and/or beta/A4 peptide accumulation may underlie the amyloidosis characteristic of t...

journal_title：Biochemical and biophysical research communications

authors： Buxbaum JD,Christensen JL,Ruefli AA,Greengard P,Loring JF

更新日期：1993-12-15 00:00:00

abstract：:The chemokine receptor CCR5 is constitutively associated with the T cell co-receptor CD4 in plasma cell membranes. The CD4-CCR5 complex exhibits distinct binding properties for macrophage inflammatory protein 1beta (MIP-1beta) and enhanced G-protein signaling as compared with those of CCR5 alone. Here we report that r...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Staudinger R

更新日期：2003-08-08 00:00:00

abstract：:The hpa cluster of Escherichia coli W ATCC 11105 encodes the enzymes involved in the catabolism of 4-hydroxyphenylacetate (4-HPA). The catabolic genes are organized in two operons, the hpaBC operon, which produces the hydroxylase activity, and the meta operon, which encodes the enzymes that cleave the aromatic ring an...

journal_title：Biochemical and biophysical research communications

authors： Prieto MA,García JL

更新日期：1997-03-27 00:00:00

abstract：:Cardiac differentiation involves a cascade of coordinated gene expression that regulates cell proliferation and matrix protein formation in a defined temporo-spatial manner. The zinc-finger-containing transcription factor has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regu...

journal_title：Biochemical and biophysical research communications

authors： Liu H,Zhu C,Luo J,Wang Y,Li D,Li Y,Zhou J,Yuan W,Ou Y,Liu M,Wu X

更新日期：2004-07-16 00:00:00

abstract：:The nuclear-mitochondrial stringent response was examined in isonuclear rho+, 21S rRNA-containing rho-, and rho o strains of S. cerevisiae. By 30 min after nutritional downshift, nuclear rDNA transcription falls to 15% of control levels congruently in all strains, as assayed via whole-cell RNA or by hybrid selection o...

journal_title：Biochemical and biophysical research communications

authors： McEntee CM,Cantwell R,Thomas LC,Hudson AP

更新日期：1989-10-16 00:00:00

abstract：:Uveitis is a sight-threatening intraocular inflammatory disease that accounts for almost 10% of blindness worldwide. NF-κB signaling plays pivotal roles in inflammatory diseases. We have reported that IMD-0354, which inhibits NF-κB signaling via selective blockade of IKK-β, suppresses inflammation in several ocular di...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Kitaichi N,Wu D,Hase K,Satoh M,Iwata D,Namba K,Kanda A,Noda K,Itai A,Iwabuchi K,Ishida S

更新日期：2020-05-07 00:00:00

abstract：:We have developed a continuous fluorescence assay based on fluorescence resonance energy transfer (FRET) for the monitoring of RNA helicase activity in vitro. The assay is tested using the hepatitis C virus (HCV) NS3 helicase as a model. We prepared a double-stranded RNA (dsRNA) substrate with a 5' fluorophore-labeled...

journal_title：Biochemical and biophysical research communications

authors： Tani H,Fujita O,Furuta A,Matsuda Y,Miyata R,Akimitsu N,Tanaka J,Tsuneda S,Sekiguchi Y,Noda N

更新日期：2010-02-26 00:00:00

abstract：:In this study, we examined the endothelin (ET) receptor subtype involved in mitogenic signaling in human primary and metastatic melanoma cell lines. In a reverse transcriptase-polymerase chain reaction (RT-PCR) study, ET(B) mRNA expression in metastatic melanoma cells was decreased from that of primary melanoma. Only ...

journal_title：Biochemical and biophysical research communications

authors： Kikuchi K,Nakagawa H,Kadono T,Etoh T,Byers HR,Mihm MC,Tamaki K

更新日期：1996-02-27 00:00:00

abstract：:Recent evidence shows that Silver-Russell syndrome (SRS), the major functional deficit of which is limited growth, both intrauterine and postnatal, is due to a double dose of a gene within 7p11.2-p13 that is normally expressed exclusively from the maternal copy. Of the several growth-related genes in this chromosomal ...

journal_title：Biochemical and biophysical research communications

authors： McCann JA,Zheng H,Islam A,Goodyer CG,Polychronakos C

更新日期：2001-09-07 00:00:00

abstract：:Oxygen exchange between high-valent metal-oxo complexes and bulk water has been monitored for nonligated model porphyrins (hemin, FeTDCPPS, MnTMPyP) and the axially ligated microperoxidase-8 (MP-8). Exchange extents up to 90% were measured for MP-8 in spite of the presence of an axial histidine ligand and accompanied ...

journal_title：Biochemical and biophysical research communications

authors： Primus JL,Teunis K,Mandon D,Veeger C,Rietjens IM

更新日期：2000-06-07 00:00:00