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A conserved region in the first intron of the insulin receptor gene binds nuclear proteins during adipocyte differentiation.

Abstract：

:The insulin receptor gene is induced 8 to 10-fold during adipocyte differentiation. Plasmids containing the promoter, exon 1 and a portion of the first intron from either the mouse or human gene are able to modulate the expression of an insulin receptor/CAT gene 3 to 7-fold during differentiation. We have shown that several nuclear proteins from both preadipocyte and adipocyte nuclear extracts bind to two discrete sites within a 278-bp region in the 5' end of the first intron. Sequence comparison between the first intron of the human gene and the mouse gene shows two regions of sequence identity which correspond to the protein binding regions detected by DNase footprinting. One of these sites binds proteins that are enriched in adipocyte nuclear extracts and can be competed by adipose regulatory element, ARE6.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

McKeon C,Accili D,Chen H,Pham T,Walker GE

doi

10.1006/bbrc.1997.7725

subject

Has Abstract

pub_date

1997-11-26 00:00:00

pages

701-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)97725-1

journal_volume

240

pub_type

杂志文章

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