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Tight binding of glucocorticoid-receptor complexes to histone-agarose.

Abstract：

:"Activated" glucocorticoid-receptor complexes purified about 3,000-fold from rat liver were found to bind to histone-agarose. Because of their tight binding, they could not be eluted from the column by high salt solution (3 M KCl) or low salt plus polyol buffer (50% ethylene glycol), but their binding could be disrupted by pyridoxal 5'-phosphate; more than 70% recovery of the "activated" receptor complexes was achieved with buffer containing 20 mM pyridoxal 5'-phosphate. This interaction of "activated" glucocorticoid-receptor complexes of rat liver with histone-agarose suggests a role of histones in the mechanism of action of steroid hormone.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ueda K,Isohashi F,Okamoto K,Kokuhu I,Kimura K,Yoshikawa K,Sakamoto Y

doi

10.1016/s0006-291x(88)80346-2

subject

Has Abstract

pub_date

1988-03-15 00:00:00

pages

763-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80346-2

journal_volume

151

pub_type

杂志文章

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