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Narcan inhibition of human liver alcohol dehydrogenase.

Abstract：

:Narcan, the pharmaceutical agent for the administration of naloxone, has been reported to antagonize ethanol intoxication. In addition to naloxone, Narcan contains the antioxidant esters methyl- and propylparaben. Pure naloxone and these two esters were examined for their capacity to inhibit ethanol oxidation by purified isozymes of human liver alcohol dehydrogenase (ADH). Naloxone (400 micromolar) fails completely to inactivate any of the three ADH isozyme classes. In contrast, methyl- and propylparaben, and some related esters, competitively inhibit the oxidation of ethanol and reduction of acetaldehyde by all isozymes examined. The reported effects of Narcan on ethanol-intoxicated animals or cells cannot be attributed to the action of naloxone.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Dingley AL,Holmquist B,Vallee BL

doi

10.1016/0006-291x(85)91802-9

subject

Has Abstract

pub_date

1985-08-30 00:00:00

pages

299-306

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)91802-9

journal_volume

131

pub_type

杂志文章

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