当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Attenuation of experimental autoimmune uveoretinitis in mice by IKKβ inhibitor IMD-0354.

Attenuation of experimental autoimmune uveoretinitis in mice by IKKβ inhibitor IMD-0354.

Abstract：

:Uveitis is a sight-threatening intraocular inflammatory disease that accounts for almost 10% of blindness worldwide. NF-κB signaling plays pivotal roles in inflammatory diseases. We have reported that IMD-0354, which inhibits NF-κB signaling via selective blockade of IKK-β, suppresses inflammation in several ocular disease models. Here, we examined the therapeutic effect of IMD-0354 in an experimental autoimmune uveoretinitis (EAU) model, a well-established animal model for endogenous uveitis in humans. Systemic administration of IMD-0354 significantly suppressed the clinical and histological severity, inflammatory edema, and the translocation of NF-κB p65 into the nucleus of retinas in EAU mice. Furthermore, IMD-0354 treatment significantly inhibited the levels of several Th1/Th17-mediated pro-inflammatory cytokines in vitro. Our current data demonstrate that inhibition of IKKβ with IMD-0354 ameliorates inflammatory responses in the mouse EAU model, suggesting that IMD-0354 may be a promising therapeutic agent for human endogenous uveitis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Liu Y,Kitaichi N,Wu D,Hase K,Satoh M,Iwata D,Namba K,Kanda A,Noda K,Itai A,Iwabuchi K,Ishida S

doi

10.1016/j.bbrc.2020.02.117

subject

Has Abstract

pub_date

2020-05-07 00:00:00

pages

589-594

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)30398-3

journal_volume

525

pub_type

杂志文章

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