Peptide sequence of an antibiotic cecropin from the vector mosquito, Aedes albopictus.

abstract：:Bryostatin-1 is a natural activator of protein kinase C and currently examined in phase I trials as anticancer agent. We found that Bryostatin-1 induced tumor necrosis factor alpha (TNF alpha) expression in the human cell line MONO-MAC-6. Using Northern blot analysis and a bioassay for the detection of the cytokine we...

journal_title：Biochemical and biophysical research communications

authors： Steube KG,Drexler HG

更新日期：1995-09-25 00:00:00

abstract：:We have analyzed the cellular effects of nanosecond pulsed electrical fields on plant cells using fluorescently tagged marker lines in the tobacco cell line BY-2 and confocal laser scanning microscopy. We observe a disintegration of the cytoskeleton in the cell cortex, followed by contraction of actin filaments toward...

journal_title：Biochemical and biophysical research communications

authors： Berghöfer T,Eing C,Flickinger B,Hohenberger P,Wegner LH,Frey W,Nick P

更新日期：2009-09-25 00:00:00

abstract：:A series of substituted 4H-3,1-benzoxazin-4-ones have been made and assayed as inhibitors of human leukocyte elastase (HLE) and other serine proteases. The benzoxazinones are kinetically competitive, alternate substrate inhibitors that inhibit by acylation and slow deacylation. Two structure-activity relationships hav...

journal_title：Biochemical and biophysical research communications

authors： Spencer RW,Copp LJ,Bonaventura B,Tam TF,Liak TJ,Billedeau RJ,Krantz A

更新日期：1986-11-14 00:00:00

abstract：:Many proteins exhibit strong binding affinities to surfaces, with binding energies much greater than thermal fluctuations. When modelling these protein-surface systems with classical molecular dynamics (MD) simulations, the large forces that exist at the protein/surface interface generally confine the system to a sing...

journal_title：Biochemical and biophysical research communications

authors： Prakash A,Sprenger KG,Pfaendtner J

更新日期：2018-03-29 00:00:00

abstract：:Purified Human Immunodeficiency Virus (HIV) was solubilized in octylglucopyranoside. After centrifugation, the supernatant was added to lipid-detergent mixed micelles. Formation of virosomes occurred during overnight dialysis. Centrifugation on a continuous glycerol gradient showed that envelope glycoproteins (gp120 a...

journal_title：Biochemical and biophysical research communications

authors： Cornet B,Vandenbranden M,Cogniaux J,Giurgea L,Dekegel D,Ruysschaert JM

更新日期：1990-02-28 00:00:00

abstract：:The cell membrane receptor for epidermal growth factor (EGF) appears to be a glycoprotein of Mr 170,000 and mediates the mitogenic and metabolic responses of cells with EGF receptors (EGF-R). Normal rat kidney (NRK) have about 3 X 10(5) EGF-R per cell. Upon transformation of NRK cells by Kirsten sarcoma virus, the tra...

journal_title：Biochemical and biophysical research communications

authors： Chua CC,Geiman DE,Schreiber AB,Ladda RL

更新日期：1984-01-30 00:00:00

abstract：:"Activated" glucocorticoid-receptor complexes purified about 3,000-fold from rat liver were found to bind to histone-agarose. Because of their tight binding, they could not be eluted from the column by high salt solution (3 M KCl) or low salt plus polyol buffer (50% ethylene glycol), but their binding could be disrupt...

journal_title：Biochemical and biophysical research communications

authors： Ueda K,Isohashi F,Okamoto K,Kokuhu I,Kimura K,Yoshikawa K,Sakamoto Y

更新日期：1988-03-15 00:00:00

abstract：BACKGROUND/AIMS:TEC, a member of the TEC family of non-receptor type protein tyrosine kinases, has recently been suggested to play a role in hepatocyte proliferation and liver regeneration. This study aims to investigate the putative mechanisms of TEC kinase regulation of hepatocyte differentiation, i.e. to explore whi...

journal_title：Biochemical and biophysical research communications

authors： Li F,Jiang Y,Zheng Q,Yang X,Wang S

更新日期：2011-01-07 00:00:00

abstract：:Using the coding region of the human CK-2 alpha cDNA as a probe for screening a genomic mouse library, positive clones representing four different genomic loci were isolated. Partial DNA sequences of these loci encompassing the first 120 nucleotides of the putative coding region are reported. One positive clone was fu...

journal_title：Biochemical and biophysical research communications

authors： Boldyreff B,Wehr K,Hecht R,Issinger OG

更新日期：1992-07-31 00:00:00

abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that is known to reduce hepatic low-density lipoprotein receptor (LDLR) levels and increase plasma LDL cholesterol. It is not clear, however, whether secreted PCSK9 degrades extrahepatic LDLRs. We present evidence that recombinant PCSK9, either...

journal_title：Biochemical and biophysical research communications

authors： Schmidt RJ,Beyer TP,Bensch WR,Qian YW,Lin A,Kowala M,Alborn WE,Konrad RJ,Cao G

更新日期：2008-06-13 00:00:00

abstract：:Many studies have been reported that tripartite motif-containing (TRIM) proteins play important roles in various cellular processes and involved in many diseases. TRIM3, a member of TRIM family, has been proved that it plays important roles in various cancers. Nevertheless, its effects on cervical cancer reminded unkn...

journal_title：Biochemical and biophysical research communications

authors： Song Y,Guo Q,Gao S,Hua K

更新日期：2018-04-06 00:00:00

abstract：:Acetylation of lysine residues is conserved in all three kingdoms; however, its role in prokaryotes is unknown. Here we demonstrate that acetylation enables the reference bacterium Escherichia coli to withstand environmental stress. Specifically, the bacterium reaches higher cell densities and becomes more resistant t...

journal_title：Biochemical and biophysical research communications

authors： Ma Q,Wood TK

更新日期：2011-07-15 00:00:00

abstract：:During retroviral assembly, tRNAs are incorporated into the virion, one of which serves as a primer for the reverse transcription reaction. Using two dimensional polyacrylamide gel electrophoresis, we have studied the patterns of tRNAs incorporated into HIV-1 (3B) produced either in the lymphoid cell line H-9 or in th...

journal_title：Biochemical and biophysical research communications

authors： Kleiman L,Caudry S,Boulerice F,Wainberg MA,Parniak MA

更新日期：1991-02-14 00:00:00

abstract：:The aim of the present study was to accomplish de novo generation of reconstituted human skin with enriched hair follicles. Dermal papillae (DP) are known to play a crucial organizing role in hair follicle induction. However, generation of enriched human hair follicles using cultured DP cells has not been accomplished...

journal_title：Biochemical and biophysical research communications

authors： Yoshida Y,Soma T,Matsuzaki T,Kishimoto J

更新日期：2019-08-27 00:00:00

abstract：:An unusual C-terminal conformation has been detected in a synthetic decapeptide designed to analyze the stereochemistry of helix termination in polypeptides. The crystal structure of the decapeptide Boc-Leu-Aib-Val-Ala-Leu-Aib-Val-(D)Ala-(D)Leu-Aib-OMe reveals a helical segment spanning residues 1-7 and helix terminat...

journal_title：Biochemical and biophysical research communications

authors： Aravinda S,Shamala N,Pramanik A,Das C,Balaram P

更新日期：2000-07-14 00:00:00

abstract：:Previous studies have shown that a specific inhibitor of insulin-like growth factor (IGF) action in vitro can be isolated from normal human serum and subsequently partially purified on an IGF-affinity column. The ability of the inhibitor to bind the IGFs has now been confirmed directly using covalent cross-linking tec...

journal_title：Biochemical and biophysical research communications

authors： Ooi GT,Herington AC

更新日期：1986-05-29 00:00:00

abstract：:Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in m...

journal_title：Biochemical and biophysical research communications

authors： Kawai I,Hisaki T,Sugiura K,Naito K,Kano K

更新日期：2012-10-26 00:00:00

abstract：:SAP90/PSD95-associated proteins (SAPAPs) are one type of scaffold protein in the postsynaptic density (PSD). Scaffold proteins play an important role in synaptic function. Recently, many studies have shown that mutations associated with scaffold proteins cause dysfunction in neuronal circuitry and in behavior. SAPAP4,...

journal_title：Biochemical and biophysical research communications

authors： Wu B,Li C,Lei H

更新日期：2018-11-10 00:00:00

abstract：:A specific peptide (SAMS peptide) phosphorylation assay has previously been used to measure and subsequently purify rat liver 5'-AMP-activated protein kinase (AMPK). In this report, we show that this peptide and a peptide based on the sequence surrounding the site phosphorylated on 3-hydroxy-3-methylglutaryl-CoA (HMG-...

journal_title：Biochemical and biophysical research communications

authors： Sullivan JE,Carey F,Carling D,Beri RK

更新日期：1994-05-16 00:00:00

abstract：:Small heat-shock proteins (sHSPs) represent an abundant and ubiquitous family of molecular chaperones. The current model proposes that sHSPs function to prevent irreversible aggregation of non-native proteins by forming soluble complex. The chaperone activity of sHSPs is usually determined by the capacity to suppress ...

journal_title：Biochemical and biophysical research communications

authors： Jiao W,Li P,Zhang J,Zhang H,Chang Z

更新日期：2005-09-16 00:00:00

abstract：:One of the mechanisms underlying the induction of human inducible nitric oxide synthase (hiNOS) by cytokines is transcriptional regulation. However, previous reports suggest that in human cells, the cytokine activation of the hiNOS expression is accompanied by a drastic increase in cellular mRNA and protein content, b...

journal_title：Biochemical and biophysical research communications

authors： Nunokawa Y,Oikawa S,Tanaka S

更新日期：1997-04-17 00:00:00

abstract：:Akt/PKB plays a pivotal role in cell survival and proliferation. Previously, we reported that UV-irradiation induces extensive cell death in Akt2(-/-) mouse embryonic fibroblasts (MEFs) while Akt1(-/-) MEFs show cell cycle arrest. Here, we find that Akt1(-/-) MEFs exhibit phenotypic changes characteristics of senescen...

journal_title：Biochemical and biophysical research communications

authors： Jee HJ,Kim HJ,Kim AJ,Bae YS,Bae SS,Yun J

更新日期：2009-06-05 00:00:00

abstract：:A monoclonal antibody (mAb) 25B1 directed against fetal bovine-serum acetylcholinesterase (FBS AChE) was used to examine the ability of the cholinergic enzyme to promote the assembly of amyloid-beta peptides (A beta) into Alzheimerś fibrils. This mAb binds to the peripheral anionic site of the enzyme and allostericall...

journal_title：Biochemical and biophysical research communications

authors： Reyes AE,Perez DR,Alvarez A,Garrido J,Gentry MK,Doctor BP,Inestrosa NC

更新日期：1997-03-27 00:00:00

abstract：:In AL-amyloidosis the cause of amyloid fibril formation in beta-pleated sheets from the precursor protein immunoglobulin light chain is not established, but studies of AL-proteins indicate that amino acid substitutions are important in the pathogenesis. Amyloid material was extracted from a subcutaneous fat tissue bio...

journal_title：Biochemical and biophysical research communications

authors： Olsen KE,Sletten K,Westermark P

更新日期：1998-04-28 00:00:00

abstract：:cDNAs were molecularly cloned for proteins specifically expressed in embryo as well as in a chemically induced rat pancreatic B cell tumor in which virally related oncogenes such as v-myc, v-src, v-yes, v-mos and v-kis were previously demonstrated not to be expressed. A plasmid cDNA library consisting of 48,000 indepe...

journal_title：Biochemical and biophysical research communications

authors： Soma G,Kitahara N,Andoh T

更新日期：1984-10-15 00:00:00

abstract：:The isolation of the genes located in chromosome 21 and the characterisation of their function are essential steps towards the understanding of the physiopathological mechanisms involved in Down syndrome. We have used two complementary approaches to characterise the function of the novel gene DSCR2 (Down Syndrome Crit...

journal_title：Biochemical and biophysical research communications

authors： Vidal-Taboada JM,Lu A,Pique M,Pons G,Gil J,Oliva R

更新日期：2000-05-27 00:00:00

abstract：:The extracellular Ca(2+) sensing receptor (CaSR) belongs to Class C G-protein-coupled receptors (GPCRs) which include receptors for amino acids, γ-aminobutyric acid and glutamate neurotransmitters. CaSR has been described as having an extended sequence containing a Ca(2+) binding pocket within an extracellular amino (...

journal_title：Biochemical and biophysical research communications

authors： Morrill GA,Kostellow AB,Gupta RK

更新日期：2015-03-27 00:00:00

abstract：:Human embryonic stem cells (hESC) are pluripotent, and can be directed to differentiate into different cell types for therapeutic applications. To expand hESCs, it is desirable to maintain hESC growth without differentiation. As hESC colonies grow, differentiated cells are often found at the periphery of the colonies,...

journal_title：Biochemical and biophysical research communications

authors： Lam H,Patel S,Wong J,Chu J,Lau A,Li S

更新日期：2008-08-08 00:00:00

abstract：:The corticotropin releasing factor (CRF) plays a central role in regulating the activities of hypothalamic-pituitary-adrenal (HPA) axis in the presence of a variety of stressful stimuli via binding to its type 1 receptors (CRFR1). Despite that many peptidic or non-peptidic antagonists of CRFR1 have been developed to s...

journal_title：Biochemical and biophysical research communications

authors： Yu J,Zhuo R,Peng P,Liu X,Yan H,Zhang S,Zheng J,Wei X,Ma X

更新日期：2015-07-31 00:00:00

abstract：:We have identified a human pituitary protein as a novel glycosylated variant of hGH. Isolation of the denatured protein included separation of human pituitary extract by Sephadex G-100 chromatography in ammonium bicarbonate, followed by Sephadex G-100 chromatography in 10% acetic acid, with subsequent DEAE Sephacryl c...

journal_title：Biochemical and biophysical research communications

authors： Haro LS,Lewis UJ,Garcia M,Bustamante J,Martinez AO,Ling NC

更新日期：1996-11-12 00:00:00